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The Vendruscolo Laboratory
www-vendruscolo.ch.cam.ac.uk/research.html28 Feb 2023: We then test further these small molecules in human cerebrospinal fluid and in a Caenorhabditis elegans model of AD. -
Sequence-based prediction of pH-dependent protein solubility using…
www-vendruscolo.ch.cam.ac.uk/Oeller-2023-BiB.pdf28 Feb 2023: Specifically, we test our methodon proteins that were either commercially available or alreadyproduced in our laboratory. -
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes
www-vendruscolo.ch.cam.ac.uk/Bhardwaj-2023-NC.pdf28 Feb 2023: Experimental analysis of aggregation-prone SARS-CoVand SARS-CoV-2 proteinsTo experimentally test the computational predictions of APRs in theSARS-CoV and SARS-CoV-2 proteomes, we investigated the in vitroaggregation ... We performed an MTT assay, a -
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience …
www-vendruscolo.ch.cam.ac.uk/Joshi-2023-ACSCN.pdf2 Mar 2023: Error bars indicate the standarderror of the mean (SEM). Statistics were performed using ordinaryone-way ANOVA Dunnett’s multiple-comparison test (p-value<0.0001; p-value = 0.0005; p-value = ... Statistical comparisons areshown using an unpaired t-test, -
PNAS 2023 Vol. 120 No. 9 e2208792120…
www-vendruscolo.ch.cam.ac.uk/Dada-2023-PNAS.pdf28 Feb 2023: As phase separation has been reported to depend on low-affinity electrostatic and hydrophobic interactions (43, 44), we used this feature to test the sensitivity of the aggregation assay described above -
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on …
www-vendruscolo.ch.cam.ac.uk/Baumann-2023-ACSCN.pdf28 Feb 2023: All samples were prepared in low-binding test tubes. Figure 5. Aβ42 does not change its secondary structure in the presence of varying concentrations of LUVs. -
Structure-Based Discovery of Small-Molecule Inhibitors of…
www-vendruscolo.ch.cam.ac.uk/Chia-2023-MP.pdf18 Mar 2023: To test for the specificity of compound C for α-synucleinfibrils, we measured the change in polarization uponincubation of compound C with Aβ42 fibrils, which areassociated with Alzheimer’s disease (Figure
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