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  2. Potent monoclonal antibodies for biologics discovery (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/potent_monoclonal_antibodies_for_biologics_discovery_non-technical_summary_redacted.pdf
    30 Apr 2024: Any new drug development can take up to 10-12 years before it can be used on human patients. ... We have developed a new method where we can screen antibody secreting B-cells directly for antigen binding.
  3. Placental epignetic programming

    https://www.ubs.admin.cam.ac.uk/system/files/public/placental_epigenetic_programming_non-technical_summary_redacted.pdf
    30 Apr 2024: Our findings will help both clinical and basic science research in reproductive biology and epigenetics to generate new research questions. ... Culture methods for human placental trophoblast cells are very new and still under development.
  4. Embryonic origins of heart disease

    https://www.ubs.admin.cam.ac.uk/system/files/public/embryonic_origins_of_heart_disease_non-technical_summary_redacted.pdf
    29 Apr 2024: The new bedding material generated much less dust. What published best practice guidance will you follow to ensure experiments are conducted inthe most refined way? ... Therefore, the project licence holder will have regular discussions with the Named
  5. Development of nerve neuroprosthetic treatment

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_nerve_neuroprosthetic_treatments_non-technical_summary_redacted.pdf
    29 Apr 2024: Supervisors teaching new PILs will do so following LASA guiding principles to ensure new users are properly trained to perform any procedures necessary. ... Supervisors teaching new licence holders will do so following LASA guiding principles to ensure
  6. Discovery and development of treatments for immunological diseases

    https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_and_development_of_treatments_for_immunological_diseases_non-technical_summary_redacted.pdf
    29 Apr 2024: goal by enabling us to test new therapeutic hypothesis in vivo relevant to new treatments for immune mediate diseases. ... This de-risks again the potential for using new therapeutic agents which are unlikely to achieve active concentrations at the
  7. Interaction between the immune system and tumours (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf
    30 Apr 2024: To the wider pharmaceutical industry and patients this could lead into the development of new anti-cancer therapies. ... Pilot studies are used to establish the correct dose of reagents/cells, timelines, and to generate baseline data for new experiments.
  8. Understanding Infection Pathogenesis to Guide Therapies…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf
    30 Apr 2024: 6.1 million deaths annually (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). ... This is confounded by the fact that there have been very few new antimicrobial products that have been developed over the last 15 years.
  9. PK and PKPD studies to support Respiratory and Immunology research

    https://www.ubs.admin.cam.ac.uk/system/files/public/pk_and_pkpd_studies_to_support_respiratory_and_immunology_research_non-technical_summary_redacted.pdf
    30 Apr 2024: To enable us to decide what doses of new treatments we need to use in our respiratory and immunology disease models. ... There are multiple stages of non-animal screening of new molecules that are in place before testing in rodent.
  10. Molecular mechanisms of tolerance and immunosuppression…

    https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_tolerance_and_immunosuppression_non-technical_summary_redacted.pdf
    30 Apr 2024: Both are important immunological processes and targets for the development of new drugs. ... There is a great unmet clinical need in this area and our experiments could inform the development of new therapeutics.
  11. Epigenetic inheritence and the control of developmental and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/epigenetic_inheritance_and_the_control_of_developmental_and_physiological_processes_non-technical_s_redacted.pdf
    30 Apr 2024: This means that others do not need to generate new mutants or samples, minimising animal numbers. ... For any new procedures we will review published protocols from experienced collaborators before conducting any experiments.

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