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p53 impairs CRISPR/Cas9 in healthy cells | Department of Biochemistry
https://www.bioc.cam.ac.uk/news/archive/2018/p53-impairs-crispr-cas9-in-healthy-cells23 Jul 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations. -
Therapeutic vulnerabilities in lung tumours with distinct p53…
https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors. -
Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry
https://www.ch.cam.ac.uk/person/arf2523 Jul 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. -
Alan Fersht | 03 - 05 Sept 2017 Cambridge, UK
https://www.ch.cam.ac.uk/pfei/alan-fersht23 Jul 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules. -
Gerard Evan | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/evan23 Jul 2024: I. (2013). Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. ... 2011). Validation of MdmX as a therapeutic target for reactivating p53 in tumors. -
Professor David Keays | Department of Physiology, Development and…
https://www.pdn.cam.ac.uk/staff/keays23 Jul 2024: Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. -
Professor Emma L Rawlins | Department of Physiology, Development and…
https://www.pdn.cam.ac.uk/directory/emma-rawlins23 Jul 2024: 2016) Mechanical cell competition kills cells via induction of lethal p53 levels. -
Extra centrosomes and cancer : New light on a century old problem |…
https://www.gen.cam.ac.uk/news/coelho-extra-centrosomes-and-cancer23 Jul 2024: The net result is hyperplasia in several tissues, which is exacerbated by the additional loss of the tumour suppressor protein p53. ... p53 is non-functional in the majority of human tumours and mice lacking p53 are prone to tumour development. -
Roderik Kortlever, PhD | Bioinformatics Training
https://bioinfotraining.bio.cam.ac.uk/staff/roderik-kortlever-phd23 Jul 2024: René Bernards . Thesis: Escaping growth arrest in cancer – Bypass of a p53 dependent cell cycle arrest. ... Selective activation of p53-mediated suppression in high-grade tumors. Nature 2010 Nov 25; 468 (7323):567- 71. -
Publications | Department of Pharmacology
https://www.phar.cam.ac.uk/research/Itzhaki/pub23 Jul 2024: S. Itzhaki, and D. R. Spring. Functionalized double strain-promoted stapled peptides for inhibiting the p53-MDM2 interaction. ... S. Verma, and L. S. Itzhaki. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2. -
Home - Dr Rana's Group
https://www.med.cam.ac.uk/rana/23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Dr Rana's Group. Welcome to Rana Lab. Research. The role of TGF-beta superfamily signalling -
Scheres lab
https://www2.mrc-lmb.cam.ac.uk/groups/scheres/publications.html23 Jul 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA". -
Publications | Centre for Experimental Biophysical Chemistry
https://www.ch.cam.ac.uk/biophyschem/publications?page=523 Jul 2024: Nat Neurosci. (2022). 25,. 1582. (doi: 10.1038/s41593-022-01206-2). Characterization of full-length p53 aggregates and their kinetics of formation. -
Lucia Pinon P Giraldez | MRC Toxicology Unit
https://www.mrc-tox.cam.ac.uk/staff/lucia-pinon-p-giraldez23 Jul 2024: Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. ... Genomic instability in mutant p53 cancer cells upon entotic engulfment. -
Publications | Wales Group
https://www.ch.cam.ac.uk/group/wales/publications?page=1423 Jul 2024: Computer Simulations of Peptides from the p53 DNA Binding Domain. M Khalili, DJ Wales. – -
Dr Ben Hall | Department of Genetics
https://www.gen.cam.ac.uk/staff/dr-ben-hall23 Jul 2024: p53 mutant progenitors colonize normal epidermis Cell Stem Cell 23(5)/2018 DOI: 10.1016/j.stem.2018.08.017. -
Publications | Department of Biochemistry
https://www.bioc.cam.ac.uk/mottowen/publications23 Jul 2024: Owen. 1996. R.J.A. Grand, D. Owen, S.M. Rookes & P.H. Gallimore (1996) "Control of p53 expression by Adenovirus-12 early region 1A and early region 1B 54K proteins" ... Levine & Gallimore, P.H. (1995) "The high levels of p53 present in Adenovirus early -
Dr Mark Bycroft | Department of Pharmacology
https://www.phar.cam.ac.uk/dr-mark-bycroft-023 Jul 2024: I also study transcription factors that play a key role in cancer such as p53 and MYC. -
Publications - Professor Bennett's Group
https://www.med.cam.ac.uk/bennett/publications/23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Professor Bennett's Group. Publications. Links. 2024 University of Cambridge. -
Featured Articles Archives - Page 14 of 32 - School of Clinical…
https://www.medschl.cam.ac.uk/category/feature/page/14/23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism
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