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21 - 30 of 71 search results for p53

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  2. Research News Archives - Page 12 of 29 - School of Clinical Medicine

    https://www.medschl.cam.ac.uk/category/schoolnews/research-news/page/12/
    23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

  3. Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/merkle
    23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation

  4. https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26

    https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26
    23 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-01-12T14:44:42","modified_gmt":"2015-01-12T14:44:42","slug":"publications","status"

  5. Professor Alan Warren | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/warren
    23 Feb 2024: consequence of p53 stabilization in response to ribosomal stress.

  6. https://www.med.cam.ac.uk/bennett/wp-json/wp/v2/pages/26

    https://www.med.cam.ac.uk/bennett/wp-json/wp/v2/pages/26
    23 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-02-06T11:14:05","modified_gmt":"2015-02-06T11:14:05","slug":"publications","status"

  7. Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/brian-huntly
    23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

  8. Dr Ingo Ringshausen - Department of Haematology

    https://www.haem.cam.ac.uk/staff/senior-staff/dr-ingo-ringshausen/
    23 Feb 2024: Swigart, and G.I. Evan. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Finch, L.B. Swigart, and G.I. Evan. Thepathological response to DNA damage does not contribute to p53-mediated tumour suppression.

  9. Publications - Professor Marciniak's Group

    https://www.med.cam.ac.uk/marciniak/publications/
    23 Feb 2024: p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.

  10. spongistatin 1

    https://www-jmg.ch.cam.ac.uk/data/molecules/polyketides/spongistatin.html
    6 May 2024: s66;P5;P57;P53;P52;P50;P24;N8;s3;s76;d76;N15;s79;N17;N29;N24;s82;s84;d84;/rC:-.3572,3.7125,0;-.3572,2.8875,0;1.0717,2.

  11. Professor Margaret Ashcroft | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/margaretashcroft
    23 Feb 2024: Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. ... Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell

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