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30 Apr 2024: Renal function can be assessed by tests performed in urine or blood collected from the animals. ... For example we use human kidney organoids to test drug activity in certain projects.

29 Apr 2024: A small subset of mice will undergo a blood test to check how much of a certain marker of interest they have (for example, a protein). ... The best, non-invasive way to monitor disease progression is to test the urine for protein.

30 Apr 2024: After this she may undergo a glucose tolerance test (as described in point 5) prior to her being humanely killed and her tissues collected and stored for laboratory analyses. ... c) Glucose or insulin tolerance tests which require injection of either

30 Apr 2024: This will allow us to change the signalling within particular cells and test the consequences on the mechanics and development of the whole organ. ... Why were they not suitable? It is not possible to entirely replace animal experiments for this project

30 Apr 2024: This will create new opportunities to test new therapies that can stop inflammation, brain damage, and the subsequent development of neuropsychiatric disorders in the offspring. ... This has allowed us to test whether treatments will be (1) safe for

29 Apr 2024: 4 or less). Followed by longer (e.g. 3, 6, 12 or 24 months), larger studies (less than 10 animals per test group at each time point).

29 Apr 2024: This will contribute to a reduction in the burden of developmental origins of heart disease, thereby having a positive clinical, economic and societal impact on health. ... The real ethical, biological and economic value of the avian relative to other

30 Apr 2024: Why were they not suitable? It is not possible to entirely replace animal experiments for this project since it is important to test whether the principles identified in cell culture are

30 Apr 2024: licence. Furthermore, when possible, we will generate primary cell lines from mouse brains which will allow us to test some of our hypotheses in vitro prior to performing elaborate experiments that ... 1) We will perform pilot studies and in vitro tests

30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and

29 Apr 2024: World Health Organisation, General Medical Council, Royal College of Veterinary Surgeons) and pharmaceutical organisations who may develop policies, diagnostic tests and therapies to combat sub/infertility, pregnancy complications and. ... It also

30 Apr 2024: endoscopy, bronchoscopy, MRI/CT/PET) and non imaging techniques (e.g. blood tests and functional assays).

30 Apr 2024: We also want to test whether subcutaneous implants can be used to accurately monitor body temperature in the mice.

30 Apr 2024: During the in vivo (performed in or on living animals) experiment, blood sample will be taken to test the generation of an antigen specific antibody response.

29 Apr 2024: We aim to test the use of the mouse grimace scale for each protocol (https://nc3rs.org.uk/grimacescales).

30 Apr 2024: We currently use several tests, depending on the kind of imaging agent, before proceeding to animal studies as follows.

30 Apr 2024: A key component of this project is to improve the diagnosis and treatment of human cancers; therefore, it is crucial to test and validate novel tools in preclinical models that involve

30 Apr 2024: Potential refinements include increased monitoring if test animals show earlier clinical signs or weight loss.

30 Apr 2024: as in vitro (performed in a test tube, culture dish or elsewhere outside of a living organism) slice cultures.

30 Apr 2024: Gene modifications are confirmed by collecting tissue biopsies (e.g. by removing a very small piece of fin or collecting skin swabs), which are then used for genetic tests.

30 Apr 2024: 4. Test experiments, called pilot experiments (which use a smaller number of animals; typically 3) will be used to calculate the amount of a substance that we can safely inject into