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Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …
https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells -
Dr Suzanne Dawn Turner | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/sdturner23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the -
Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery. -
School News Archives - Page 12 of 29 - School of Clinical Medicine
https://www.medschl.cam.ac.uk/category/schoolnews/page/12/23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism -
Publications - Dr Rana's Group
https://www.med.cam.ac.uk/rana/publications/23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Dr Rana's Group. Publications. 2024 University of Cambridge. -
Dr Maria Christophorou | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/christophorou23 Feb 2024: She did her PhD with Gerard Evan at UCSF, where she was able to dissect the relative contributions of different p53 activating signals towards tumour suppression using mouse models of conditional ... p53 perturbation. -
Research News Archives - Page 12 of 29 - School of Clinical Medicine
https://www.medschl.cam.ac.uk/category/schoolnews/research-news/page/12/23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism -
Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/merkle23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation -
https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26
https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/2623 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-01-12T14:44:42","modified_gmt":"2015-01-12T14:44:42","slug":"publications","status" -
Professor Alan Warren | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/warren23 Feb 2024: consequence of p53 stabilization in response to ribosomal stress.
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