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9 Jul 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations.

23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors.

8 Jul 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... doi:A Structure-Guided Molecular Chaperone Approach for Restoring the Transcriptional Activity of the p53 Cancer Mutant Y220C.

8 Jul 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules.

9 Jul 2024: I. (2013). Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. ... 2011). Validation of MdmX as a therapeutic target for reactivating p53 in tumors.

9 Jul 2024: Long term aggresome accumulation leads to DNA damage, p53-dependent cell cycle arrest, and steric interference in mytosis, J.

9 Jul 2024: Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.

9 Jul 2024: 2016) Mechanical cell competition kills cells via induction of lethal p53 levels.

9 Jul 2024: S. Itzhaki, and D. R. Spring. Functionalized double strain-promoted stapled peptides for inhibiting the p53-MDM2 interaction. ... S. Verma, and L. S. Itzhaki. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2.

9 Jul 2024: The net result is hyperplasia in several tissues, which is exacerbated by the additional loss of the tumour suppressor protein p53. ... p53 is non-functional in the majority of human tumours and mice lacking p53 are prone to tumour development.

9 Jul 2024: René Bernards . Thesis: Escaping growth arrest in cancer – Bypass of a p53 dependent cell cycle arrest. ... Selective activation of p53-mediated suppression in high-grade tumors. Nature 2010 Nov 25; 468 (7323):567- 71.

8 Jul 2024: doi: 10.1016/0009-2614(86)80452-3). Characterization of full-length p53 aggregates and their kinetics of formation.

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Dr Rana's Group. Welcome to Rana Lab. Research. The role of TGF-beta superfamily signalling

9 Jul 2024: p53 mutant progenitors colonize normal epidermis Cell Stem Cell 23(5)/2018 DOI: 10.1016/j.stem.2018.08.017.

9 Jul 2024: Owen. 1996. R.J.A. Grand, D. Owen, S.M. Rookes & P.H. Gallimore (1996) "Control of p53 expression by Adenovirus-12 early region 1A and early region 1B 54K proteins" ... Levine & Gallimore, P.H. (1995) "The high levels of p53 present in Adenovirus early

9 Jul 2024: Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. ... Genomic instability in mutant p53 cancer cells upon entotic engulfment.

8 Jul 2024: Imaging aggregates of P53 and determining the role of these aggregates in the development and spreading of cancer.

9 Jul 2024: CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat. Med., 24(7):927-930.

9 Jul 2024: Contributors: Ingrida Olendraite; Katherine Brown; Andrew E. Firth. A novel map of human p53 response elements uncovers evidence of selection pressures and variants similar to Li-Fraumeni Syndrome mutations. ... Germline and Somatic Genetic Variants in

9 Jul 2024: ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

8 Jul 2024: Nature neuroscience. (2022). 25,. 1582. (doi: 10.1038/s41593-022-01206-2). Characterization of full-length p53 aggregates and their kinetics of formation.

9 Jul 2024: I also study transcription factors that play a key role in cancer such as p53 and MYC.

8 Jul 2024: 2009). 130,. 194508. (doi: 10.1063/1.3131690). Computer Simulations of Peptides from the p53 DNA Binding Domain.

8 Jul 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.

9 Jul 2024: Projects included an orca sound ocean simulator, numerous artistic projects such as a DNA helix light and programmed light installation displaying the p53 sequence, sensors, drones and more.

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Professor Bennett's Group. Publications. Links. 2024 University of Cambridge.

23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.

5 Jul 2024: and Schrick, K., 2020. Dietary flavonoid fisetin binds human SUMO1 and blocks sumoylation of p53.

6 Jul 2024: Chiba Ene (PhD Medical Sciences) - Histone demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Activity through Lysine Demethylation.

23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Dr Rana's Group. Publications. 2024 University of Cambridge.

23 Feb 2024: Marciniak. 2013. p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress.

8 Jul 2024: Journal: Scientific Reports 12 (1). ------------------------------. Characterization of full-length p53 aggregates and their kinetics of formation.

8 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not

8 Jul 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel

9 Jul 2024: Cancer studies. Including cell cycle and cancer, use of mouse models, genome-wide sequencing and genome-wide disease association, leukaemia, p53, cancer therapeutics, recombinant antibody generation, commercial drug design and development,

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Kaser Group. Publications. Reviews & Editorials. 2024 University of Cambridge.

9 Jul 2024: Department of Physiology, Development and Neuroscience - Academics https://www.pdn.cam.ac.uk/directory/faculty en Sumru Bayin https://www.pdn.cam.ac.uk/staff/bayin <div class="field field-name-field-sd-consultancy field-type-list-boolean

23 Feb 2024: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels.

9 Jul 2024: b>. Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.

23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation

23 Feb 2024: She did her PhD with Gerard Evan at UCSF, where she was able to dissect the relative contributions of different p53 activating signals towards tumour suppression using mouse models of conditional ... p53 perturbation.

23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the

23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells

3 May 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA".

20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.