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23 Feb 2024: Defects in the ability to mount effective B cell or T cell responses have been implicated in infectious susceptibility, impaired surveillance of cancer and immunodeficiencies, whereas a breakdown of immunological tolerance ... Transmission and evolution

9 May 2024: Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury. ... Monocytes control second-phase neutrophil emigration in established LPS-induced murine lung injury.

12 May 2021: the process by which new variants likely arise, and also reporting the first data on Pfizer BioNTech vaccine-induced antibody responses against the B.1.1.7 ‘Kent UK’ variant. ... His research investigates the basis for pathological immune activation

She leads and collaborates in research on HIV, FIV (feline immunodeficiency virus), dengue virus and influenza virus. ... Viruses 3(11) 2192-2213. Kenyon JC, Lever AML (2011) XMRV, Prostate Cancer and Chronic Fatigue Syndrome.

9 May 2024: In recent years, he has contributed to the description of a new primary immunodeficiency syndrome caused by activated PI3Kδ mutations (APDS) and his group demonstrated that deletion of PI3Kδ in regulatory

23 Feb 2024: Large genome-wide association study identifies three novel risk variants for restless legs syndrome. ... Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature. 2020 Jul;583(7814):90-95.

9 May 2024: Epstein-Barr Virus Induced One-Carbon Metabolism Drives B-Cell Transformation. 2019. Cell Metabolism. ... Temporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing.

9 May 2024: CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages. ... 2009). Multiple redundant stress resistance mechanisms are induced i<i>n Salmonella enterica </i>serovar Typhimurium<i> </i>in response to modulation

23 Feb 2024: The department has an interest in innate immunity, B cell lineage and repertoire development; natural and vaccine induced immunity to streptococcus pneumonia in health and chronic disease. ... Anti-tumour necrosis factor-alpha therapy for severe

22 Oct 2013: The researchers first examined genetic information from individuals who suffer from immunodeficiency and are predisposed to infections. ... The newly identified disease has been called Activated PI3K-δ Syndrome (APDS) after the enzyme that is affected