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Extracellular protein homeostasis in neurodegenerative diseases
www-vendruscolo.ch.cam.ac.uk/Wilson-2023-NRN.pdf28 Feb 2023: Overexpression of wild-type transthyre-tin in the APP23 mouse model of AD reduced cognitive and motor impairments, whereas silencing of the endogenous transthyretin gene promoted neuropathology76. ... Inspired by this mechanism, endogenous internal-izing -
Chih-Chun Chen and Nathan Crilly A PRIMER ON THE ...
https://www-edc.eng.cam.ac.uk/files/modularity_1.pdf21 Oct 2022: Chih-Chun Chen and Nathan Crilly. A PRIMER ON THE DESIGN AND SCIENCE OF COMPLEX SYSTEMS. FROM MODULARITY TO EMERGENCE. CUED/C-EDC/TR.166Engineering Design CentreDepartment of Engineering. OVERVIEW. Electrical networks, flocking birds, transportation -
The Cambridge Seminar on Financial Regulation
https://www.cerf.cam.ac.uk/files/media/programme4.pdf10 Jan 2023: Yacine Ait-Sahalia (Princeton). 9.30 am Discussant: Vanessa Smith (CERF). 9.50 am Paper 4: Endogenous Market Turbulence. -
1 MRC Toxicology Unit- History 1947- The Toxicology Unit ...
https://www.mrc-tox.cam.ac.uk/files/mrc_toxicology_unit_history.pdf6 Mar 2023: degrees of alkylation by endogenous agents such as those from lipid peroxidation. ... causal molecular mechanisms of external and endogenous toxic agents with adverse outcomes. -
#CamFest Speaker Spotlight
https://www.cam.ac.uk/stories/cambridge-festival-spotlights/alpar-lazar20 Mar 2023: stimuli. However, during sleep, the brain returns to a default state where neurons, mostly undisturbed by intrinsic and extrinsic factors, start communicating in their own ‘endogenous’ language as reflected by unique
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McMahon Group publications
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/papers.html20 Mar 2023: Endogenous GRAF1a was found on lipid droplets in oleic-acid-fed primary glial cells. -
https://cbr.blog.jbs.cam.ac.uk/tag/evolution/feed/
https://cbr.blog.jbs.cam.ac.uk/tag/evolution/feed/6 Feb 2023: And this is in turn determined by environmental (exogenous) factors as much as by internal (endogenous) ones./p pIf the external environment is changing rapidly then mutations (innovations) might also be -
https://cbr.blog.jbs.cam.ac.uk/tag/conservation/feed/
https://cbr.blog.jbs.cam.ac.uk/tag/conservation/feed/6 Feb 2023: And this is in turn determined by environmental (exogenous) factors as much as by internal (endogenous) ones./p pIf the external environment is changing rapidly then mutations (innovations) might also be -
Nine Cambridge scientists among the new 2022 Fellows announced by the …
https://www.cam.ac.uk/research/news/nine-cambridge-scientists-among-the-new-2022-fellows-announced-by-the-royal-society10 May 2022: His discovery of the ‘HUSH’ epigenetic silencing complex explains how the genome distinguishes new genetic material from endogenous genes through recognition of intronless DNA.
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The Vendruscolo Laboratory
www-vendruscolo.ch.cam.ac.uk/research.html28 Feb 2023: The endogenous proteins that are sequestered by the aggregates share distinct physicochemical properties: They are relatively large in size and significantly enriched in predicted unstructured regions, features that are strongly linked
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