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Neurobehavioural Mechanisms Underlying Mood, Impulsive and Compulsive …
https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_impulsive_and_compulsive_mental_health_disorders_non-t_redacted.pdf30 Apr 2024: The cost of mental health disorders to the UK in terms of social, economic and health factors is extremely high. ... As we are interested in adult behaviour, the majority of our behavioural tests will be conducted in adult animals. -
Neurobehavioural Mechanisms Underlying Mood, Anxiety and…
https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_anxiety_and_stress-related_mental_health_disorders_non_redacted.pdf30 Apr 2024: As we are interested in adult behaviour, the majority of our behavioural tests will be conducted in adult animals. ... We perform these manipulations to test the impact of early life stress on the behaviour of the offspring as adults. -
Neural, physiological and behavioural mechanisms underlying cognition …
https://www.ubs.admin.cam.ac.uk/system/files/public/neural_physiological_and_behavioural_mechanisms_underlying_cognition_and_emotion_non-technical_sum_redacted.pdf30 Apr 2024: of cognitive and emotional symptoms of neuropsychiatric disorders will have far reaching social and economic implications. ... can move freely once in the test apparatus and (iii) are tested for less than 40 minutes. -
CNS Neuron-glia interactions, myelin plasticity, and regeneration, in …
https://www.ubs.admin.cam.ac.uk/system/files/public/cns_neuron-glia_interactions_myelin_plasticity_and_regeneration_in_health_and_disease_non-techni_redacted.pdf30 Apr 2024: We expect to uncover a pathway to promote myelin regeneration, and test its therapeutic potential. ... tests, or labelling (with dyes or fluorescent markers) the central nervous system under non recovery anaesthesia. -
Understanding Infection Pathogenesis to Guide Therapies…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf30 Apr 2024: Downloaded: 9:17pm, 25 Apr 2024 Page 4 of 8. scientific tests have been developed for it which we could make use of to investigate in our study. ... Potential refinements include increased monitoring if test animals show earlier clinical signs or weight -
Understanding the roles of autophagy and related pathways in…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_roles_of_autophagy_and_related_pathways_in_proteinopathies_non-technical_summary_redacted.pdf30 Apr 2024: The exact set of behavioural tests will be used is dependent on the mouse model being investigated. ... Our assessment includes both non-regulated and regulated tests, most having no noticeable adverse effects. -
Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …
https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf30 Apr 2024: This project aims to improve our understanding of the cellular mechanisms that underlie ischaemia-reperfusion injury (tissue damage caused when blood supply returns to tissue) and test the safety and effectiveness ... This project will generate academic -
Biobehavioural basis of the individual vunerability to impulsive…
https://www.ubs.admin.cam.ac.uk/system/files/public/biobehavioural_basis_of_the_individual_vulnerability_to_impulsivecompulsive_spectrum_disorders_redacted.pdf29 Apr 2024: Each of our experiments is designed on the back of a robust statistical approach that relies on state-of-the-art statistical tests and models. ... covariance, and associated post-hoc tests, dimensional analyses, such as multiple and factorial regressions, -
Early life origins of heart disease in mammals (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/early_life_origins_of_heart_disease_in_mammals_non-technical_summary_redacted.pdf30 Apr 2024: This will help reduce the vast burden of pregnancy-induced origins of cardiovascular disease, thereby having a major clinical, economic, and societal impact on cardiovascular health. ... It may be possible in future to extend some of the work by using
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