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The development of in vivo expressed biologics as a platform for…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf30 Apr 2024: This work will make extensive use of pilot studies, as most of the test substances will be by definition novel, as they concern novel technologies or modalities (method of treatment). ... Pilot or tolerability studies will be carried out for new models -
New treatments for renal and liver disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf30 Apr 2024: Renal function can be assessed by tests performed in urine or blood collected from the animals. ... For example we use human kidney organoids to test drug activity in certain projects. -
Interventions in pregnancy effects of obesity on maternal and…
https://www.ubs.admin.cam.ac.uk/system/files/public/interventions_in_pregnancy_effects_of_obesity_on_maternal_and_offspring_health_non-technical_summa_redacted.pdf30 Apr 2024: After this she may undergo a glucose tolerance test (as described in point 5) prior to her being humanely killed and her tissues collected and stored for laboratory analyses. ... c) Glucose or insulin tolerance tests which require injection of either -
Mechanisms of organ development and disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_of_organ_development_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: This will allow us to change the signalling within particular cells and test the consequences on the mechanics and development of the whole organ. ... Why were they not suitable? It is not possible to entirely replace animal experiments for this project -
Metabolic basis of microglia function in development (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf30 Apr 2024: This will create new opportunities to test new therapies that can stop inflammation, brain damage, and the subsequent development of neuropsychiatric disorders in the offspring. ... This has allowed us to test whether treatments will be (1) safe for -
In vivo compressive forces (non-technical summary)_Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf30 Apr 2024: Why were they not suitable? It is not possible to entirely replace animal experiments for this project since it is important to test whether the principles identified in cell culture are -
Mouse developmental genetics to study neurodevelopment and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/mouse_developmental_genetics_to_study_neurodevelopment_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: licence. Furthermore, when possible, we will generate primary cell lines from mouse brains which will allow us to test some of our hypotheses in vitro prior to performing elaborate experiments that ... 1) We will perform pilot studies and in vitro tests -
Early human development and the germline (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/early_human_development_and_the_germline_non-technical_summary_redacted.pdf30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and -
Implantation of seeded scaffolds for tissue!organ development…
https://www.ubs.admin.cam.ac.uk/system/files/public/implantation_of_seeded_scaffolds_for_tissueorgan_development_non-technical_summary_redacted.pdf30 Apr 2024: endoscopy, bronchoscopy, MRI/CT/PET) and non imaging techniques (e.g. blood tests and functional assays). -
Regulation of the mammalian reproductive axis
https://www.ubs.admin.cam.ac.uk/system/files/public/regulation_of_the_mammalian_reproductive_axis._non-technical_summary_redacted.pdf30 Apr 2024: We also want to test whether subcutaneous implants can be used to accurately monitor body temperature in the mice.
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