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PII: S1388-1981(99)00150-X
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10570253.pdf20 Apr 2002: from PLC-N1 (pdb entry code 1MAI) was determined independently of the structure of theremainder of the enzyme (pdb entry code 2ISD). ... Sequence analysis suggests that. Fig. 7. The C2 domain. The C2 domains from PLC-N1 and PKCL (pdb entry code 1A25) are -
30 Apr 2004 18:9 AR AR214-BB33-09.tex AR214-BB33-09.sgm…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/annrev2004.pdf1 May 2004: have similar, almost exchangeable functions, asdemonstrated recently by a gain-of-function point mutation in FtsA that removesthe requirement for ZipA completely (45). ... maritima(Figure 10). The protein was found to polymerizeeasily under mild -
PII: S0166-2236(03)00131-0
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/25_Hegde_RS_TINS_2003.pdf30 Jun 2003: neurodegeneration [1]. Yet, all heritable and transmissibleprion diseases seem to share certain characteristicpathological changes and an obligate requirement forPrP expression, suggesting at least some common aspectsto their pathogenesis. -
Molecular mechanism and physiological functions of clathrin-mediated…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/McMahon%20NRMB%202011.pdf19 Jul 2011: In this case, the clathrin lattice may serve as a signalling platform for actin polymerization, which may thus make it indispen sible for cellular entry of these very large cargoes. ... The pathway is also exploited by toxins, viruses and bacteria to -
PII: S0014-5793(01)02216-5
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MinD%20FEBS.pdf5 Mar 2001: 3. Results. Structurally MinD closely resembles other nucleotide bind-ing proteins such as nitrogenase iron proteins and GTPasessuch as Ffh (PBD entry 1NG1 [20]), part of the signal recog-nition particle ... The nucleotide binding surface of MinD is the -
nature14896 493..505
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/95_Brown_A_Nature_2015.pdf19 Aug 2015: In the structures here, the essentialNIKS sequence (residues 61–64)21, located at the end of helix a2,imposes a requirement for uridine in the first (11) position via inter-actions ... Purines would be disfavoured at the 11 position by steric -
Structural and Mechanistic Comparison of Prokaryotic and Eukaryotic…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9466937.pdf15 Jan 1998: Results and Discussion. The PI-PLC fold. The crystal structures of PI-PLC from Bacilluscereus (bPI-PLC; PDB entry code 1PTD) and PI-. ... entry ofphospholipid head groups into the active site orthe release of product following catalysis. -
Protein-driven membrane stresses in fusion and fission
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/KozlovCurvature2010.pdf21 Feb 2011: Proteins as energy generators for membraneremodelingMembrane remodeling, either by fusion or fission, canoccur if two physical requirements are fulfilled. ... Thereare two important requirements for this mechanism ofmembrane fusion. First, the -
Protein-driven membrane stresses in fusion and fission
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Kozlov%20Trends%20Biochem%20Sci%202010.pdf20 Nov 2010: Proteins as energy generators for membraneremodelingMembrane remodeling, either by fusion or fission, canoccur if two physical requirements are fulfilled. ... Thereare two important requirements for this mechanism ofmembrane fusion. First, the -
Bacterial actin MreB assembles in complex with cell shape protein RodZ
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/embo2010RodZMreB.pdf17 Feb 2010: superposition on the DNA complex of phage 343 repressor. (PDB entry 2or1; Aggarwal et al, 1988). ... Colour code as in (B). Double-stranded DNA in grey (taken from pdb entry 2OR1). -
Cryo‐EM structure of the full‐length Lon protease from Thermus…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Lon%20Coscia%202021%20FEBS.pdf14 Nov 2021: collar, may facilitate substrate entry and possibly also. help with translocation into the AAA+ channel. ... tral channel, which possibly facilitates the entry of cer-. tain substrates (and itself). -
01Eichler(Hedge)
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/33_Hegde_RS_Chapter_2005.pdf31 Oct 2005: By contrast, translocation into the ER (open arrow) is often regarded as a constitutive process wherethe presence of a signal sequence in a protein predetermines its entry into the ER. ... Thus, the entry of proteins into the ER is not necessarilya -
Structure of the hexagonal surface layer on Caulobacter crescentus…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/s-layer-nmicrobiol201759.pdf6 Apr 2017: All residues in the RsaA249–1026 X-ray structure are well ordered,reflecting a requirement that the S-layer lattice must avoid flexibleloops, as they would be easy targets for hostile ... Despite forming a con-tinuous sheet, there is a requirement for -
Dynamic Filaments of the Bacterial Cytoskeleton
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/annrev2006.pdf19 Apr 2006: arrow). (center,top) Note the closed conformation (PDB entry 1MWM) and (bottom) the open conformation of the apoand ADP-bound forms of ParM, both from E. ... right) AMPPNP-bound FtsA from T. maritima (PDB entry 1E4G)(136). www.annualreviews.org • -
Quality and quantity control at the endoplasmic reticulum
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/65_Hegde_RS_COCB_2010.pdf7 Jun 2010: Given the ability of certain proteins to insert in,and possibly traverse the lipid bilayer spontaneously, withno essential requirement for membrane proteins demon-strated [34], alternatives to protein-conducting channelsshould probably ... 20! Bernasconi -
The mechanisms of integral membrane protein biogenesis
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/NRMCB_2021.pdf22 Sep 2021: The minimum requirement for SRP recognition is a predominantly hydrophobic sequence of approximately seven amino acids. ... e | Tail- anchored (TA) protein insertion by the guided entry of TA protein (GET) pathway. -
mmi_3991.fm
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ftsn2004.pdf15 Apr 2004: The requirement of FtsN for cell division in. E. coli. became obvious with a conditional null allele of the. ... Residues A127-L132apparently contribute a fourth helix, the Table entries forwhich are italicized here because they involve non-nativeresidues -
Bacterial chromosome segregation: structure andDNA binding of the Soj …
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/soj_embo2005.pdf30 Jan 2005: confirming that ATP-dependent dimerisation is the critical. requirement for assembly of the protein onto DNA (Figure. ... domains dimerise, a requirement for HTH-mediated DNA. binding (Leonard et al, 2004). -
The structure of human thyroglobulin
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TG_Nature2020.pdf31 Jan 2020: To validate our list of requirements for hormonogenesis from poly-peptide chains, we set out to engineer synthetic T4 hormonogenic sites into the unrelated bacterial MBP. ... 4. Cahnmann, H. J., Pommier, J. & Nunez, J. Spatial requirement for coupling of -
Filament structure and subcellular organization of the bacterial…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Liu_PNAS_crescentin_2024.pdf28 Apr 2024: Functional Requirements. Having determined the assembly and subcellular organization of CreS, we next addressed the molecular determinants of CreS- dependent cell curvature generation. ... Nevertheless, correct CreS assembly is not the only functional
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