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26 Jul 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

26 Jul 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules.

26 Jul 2024: Lee. (2023). (doi: 10.1101/2023.02.07.527479). Characterization of full-length p53 aggregates and their kinetics of formation.

26 Jul 2024: Nature neuroscience. (2022). 25,. 1582. (doi: 10.1038/s41593-022-01206-2). Characterization of full-length p53 aggregates and their kinetics of formation.

26 Jul 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel

26 Jul 2024: Imaging aggregates of P53 and determining the role of these aggregates in the development and spreading of cancer.

31 Oct 2013: We discov-ered that normal p53 in a cell melts at44C, only just above body tempera-ture. ... p53 inactive simply make it less stable,and start melting at body temperatureor below.’.

26 Jul 2024: Lee. (2023). (doi: 10.1101/2023.02.07.527479). Characterization of full-length p53 aggregates and their kinetics of formation.

26 Jul 2024: J Chem Phys. (2009). 130,. 194508. (doi: 10.1063/1.3131690). Computer Simulations of Peptides from the p53 DNA Binding Domain.

9 Jul 2024: The best students got this correct. Many students also thought the protein, p53 had disulphide bridges. ... p53 was covered in the lectures as a nuclear protein that bound DNA so they should have been aware it is in a reducing environment.