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search results for p53 |u:www2.mrc-lmb.cam.ac.uk
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https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/117
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/117n. Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21808
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21808{"id":21808,"date":"2021-11-24T16:17:22","date_gmt":"2021-11-24T16:17:22","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=21808"},"modified":"2024-04-12T12:09:08","modified_gmt":"2024-04-12T11:09:08","slug":"how-dna-damage-induces-appetite-supp -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/61
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/61{"id":61,"date":"2012-06-25T10:03:42","date_gmt":"2012-06-25T10:03:42","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=61"},"modified":"2024-05-20T14:39:16","modified_gmt":"2024-05-20T13:39:16","slug":"protein-and-nucleic-acid-ch -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11414
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11414{"id":11414,"date":"2018-01-04T09:33:03","date_gmt":"2018-01-04T09:33:03","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/?p=11414"},"modified":"2020-11-19T16:55:54","modified_gmt":"2020-11-19T16:55:54","slug":"uncovering-alcohol-derived-metabolite -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3320
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3320n. Professor Sir Alan Fersht, FRS, from the PNAC Division of LMB, has been awarded an Advanced ERC Grant of u20ac1.5m for his project u201cTumour suppressor p53: structure, stability and ... 70% of human cancers have p53 directly inactivated by mutation. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11070
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11070can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. ... This deactivation allows p53 to be turned on, putting the brakes on cancer growth. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/10488
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/10488{"id":10488,"date":"2017-05-11T09:38:13","date_gmt":"2017-05-11T08:38:13","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/?p=10488"},"modified":"2019-10-24T14:30:10","modified_gmt":"2019-10-24T13:30:10","slug":"dynamic-structure-human-dna-repair-en -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3293
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3293nAlan will continue to lead his research on the p53 tumour suppressor protein at the LMB with an MRC programme grant for the next five years. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/18741
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/18741{"id":18741,"date":"2020-08-04T17:10:07","date_gmt":"2020-08-04T16:10:07","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=18741"},"modified":"2020-08-04T17:10:09","modified_gmt":"2020-08-04T16:10:09","slug":"alan-fersht-and-marta-zlatic-win-roy -
Photochemical genetics
https://www2.mrc-lmb.cam.ac.uk/ccsb/research/photochemical-genetics/In additional experiments we were able to cage a key lysine in a nuclear localization signal in p53, and define the contribution of that signal to the kinetics of nuclear import. -
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/52
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/52a protein to control its function.u00a0 In additional experiments we were able to cage a key lysine in a nuclear localization signal in p53, and define the contribution of that -
Post-translational modifications
https://www2.mrc-lmb.cam.ac.uk/ccsb/research/post-translational-modifications/Chin, W. Fischle, S.M. Gasser. Acetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration. -
All publications
https://www2.mrc-lmb.cam.ac.uk/ccsb/publications/all-publications-2/Chin, W. Fischle, S.M. Gasser. (53) Acetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration. -
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/46
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/46Fischle, S.M. Gasserem. u00a0/em/pnpstrongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr /na -
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/312
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/312Fischle, S.M. Gasserem. u00a0/em/pnp(53)u00a0strongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr /na
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