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Alan Fersht - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/alan-fersht/21 Jul 2023: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53..
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Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.
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https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3293
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3293 -
Emeritus - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/21 Jul 2023: Tumour suppressor p53 structure and drug discovery. LMB Division - Protein and Nucleic Acid Chemistry.
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https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21808
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21808{"id":21808,"date":"2021-11-24T16:17:22","date_gmt":"2021-11-24T16:17:22","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=21808"},"modified":"2024-04-12T12:09:08","modified_gmt":"2024-04-12T11:09:08","slug":"how-dna-damage-induces-appetite-supp -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/61
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/61{"id":61,"date":"2012-06-25T10:03:42","date_gmt":"2012-06-25T10:03:42","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=61"},"modified":"2024-05-20T14:39:16","modified_gmt":"2024-05-20T13:39:16","slug":"protein-and-nucleic-acid-ch -
Dynamic structure of human DNA repair enzyme, ATM, revealed - MRC…
https://www2.mrc-lmb.cam.ac.uk/dynamic-structure-human-dna-repair-enzyme-atm-revealed/11 May 2017: the damage, including arresting the cell cycle by phosphorylating the checkpoint kinase CHK2 and, under some conditions, inducing apoptosis by phosphorylating p53 and preventing its degradation. ... Using p53 produced by Tomas Kouba in Alan Fersht’s
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index.html
https://www2.mrc-lmb.cam.ac.uk/groups/fersht/26 Jan 2021: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Tumour Suppressor p53. Structural Biology and Drug Discovery. Alan Fersht. MRC Laboratory of Molecular Biology. -
Scheres lab
https://www2.mrc-lmb.cam.ac.uk/groups/scheres/publications.html23 Jul 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA". -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/117
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/117n. Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules.
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