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search results for p53 |u:www.ch.cam.ac.uk
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Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry
https://www.ch.cam.ac.uk/person/arf258 Jul 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... doi:A Structure-Guided Molecular Chaperone Approach for Restoring the Transcriptional Activity of the p53 Cancer Mutant Y220C. -
Alan Fersht | 03 - 05 Sept 2017 Cambridge, UK
https://www.ch.cam.ac.uk/pfei/alan-fersht8 Jul 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules. -
Publications | Centre for Experimental Biophysical Chemistry
https://www.ch.cam.ac.uk/biophyschem/publications?page=508 Jul 2024: doi: 10.1016/0009-2614(86)80452-3). Characterization of full-length p53 aggregates and their kinetics of formation. -
Publications | Wales Group
https://www.ch.cam.ac.uk/group/wales/publications?page=148 Jul 2024: 2009). 130,. 194508. (doi: 10.1063/1.3131690). Computer Simulations of Peptides from the p53 DNA Binding Domain. -
Professor Sir David Klenerman FMedSci FRS | Yusuf Hamied Department…
https://www.ch.cam.ac.uk/person/dk100128 Jul 2024: Imaging aggregates of P53 and determining the role of these aggregates in the development and spreading of cancer. -
Publications | Centre for Experimental Biophysical Chemistry
https://www.ch.cam.ac.uk/biophyschem/publications?page=58 Jul 2024: Nature neuroscience. (2022). 25,. 1582. (doi: 10.1038/s41593-022-01206-2). Characterization of full-length p53 aggregates and their kinetics of formation. -
Publications | Clarke Group
https://www.ch.cam.ac.uk/group/sclarke/publications?page=28 Jul 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
Protein engineering pioneer awarded Royal Society Copley Medal |…
https://www.ch.cam.ac.uk/news/protein-engineering-pioneer-awarded-royal-society-copley-medal8 Jul 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel
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