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  2. The development of in vivo expressed biologics as a platform for…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf
    30 Apr 2024: Therefore there is a clear need to pioneer new medical treatments and technologies to address this increasing disease burden. ... This will inform specific drug projects that are aiming to produce new medicines for patients.
  3. Platelets as a therapeutic tool

    https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf
    30 Apr 2024: If the pilot experiment raises unexpected new questions, a subsequent pilot experiment will be performed. ... We will routinely check the NC3R's resource library and keep abreast with, and implement where appropriate, any new advances in refinement,
  4. Control of equine herpesviruses in the horse

    https://www.ubs.admin.cam.ac.uk/system/files/public/control_of_equine_herpesviruses_in_the_horse._non-technical_summary_redacted.pdf
    29 Apr 2024: This project will develop and test the safety and effectiveness of new vaccines against EHV induced disease. ... Comprehensive details are provided for the new owner and advice given in any areas required.
  5. The diversity of glia in health, development and disease…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_diversity_of_glia_in_health_development_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: We hope that this will help us develop new treatments for diseases that are caused by problems with myelin. ... Other enrichments like tunnels, climbing structures, and new objects can be added to encourage natural behavior.
  6. Multi-tissue mechanics in the development and engineering of the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/multi-tissue_mechanics_in_the_development_and_engineering_of_the_posterior_body_axis_non-technical_redacted.pdf
    30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.
  7. Development of novel therapeutics for pain (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_novel_therapeutics_for_pain_non-technical_summary_redacted.pdf
    30 Apr 2024: relevant disease animal models to give us an extra layer of confidence in developing these new medications. ... In all new studies undertaken, the level of insult will be assessed before conducting further studies.
  8. Potent monoclonal antibodies for biologics discovery (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/potent_monoclonal_antibodies_for_biologics_discovery_non-technical_summary_redacted.pdf
    30 Apr 2024: Any new drug development can take up to 10-12 years before it can be used on human patients. ... We have developed a new method where we can screen antibody secreting B-cells directly for antigen binding.
  9. Development of nerve neuroprosthetic treatment

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_nerve_neuroprosthetic_treatments_non-technical_summary_redacted.pdf
    29 Apr 2024: Supervisors teaching new PILs will do so following LASA guiding principles to ensure new users are properly trained to perform any procedures necessary. ... Supervisors teaching new licence holders will do so following LASA guiding principles to ensure
  10. The development of novel therapies (including cell and gene based…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf
    30 Apr 2024: In the long-term we hope that this work will lead to translational outputs in the form of clinical trials around new therapeutic agents. ... establishing a new colony of mice from frozen eggs and/or sperm) any further strains of mice we need for this
  11. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf
    30 Apr 2024: They enable us to test the effect of new treatments in a relevant and intact biological system. ... This project will provide important information to progress new treatments through the phases of drug development.

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