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  2. Placental epignetic programming

    https://www.ubs.admin.cam.ac.uk/system/files/public/placental_epigenetic_programming_non-technical_summary_redacted.pdf
    30 Apr 2024: Our findings will help both clinical and basic science research in reproductive biology and epigenetics to generate new research questions. ... Culture methods for human placental trophoblast cells are very new and still under development.
  3. Early human development and the germline (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/early_human_development_and_the_germline_non-technical_summary_redacted.pdf
    30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and ... We have reduced significantly the number of mice
  4. Cartilage repair and replacement

    https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf
    29 Apr 2024: Animals will be brought in and allowed to acclimatise for a few weeks - this helps them to relax in their new surroundings, gets them used to the staff and human contact ... bones, which acts as a shock absorber), to which the new implant/therapy will be
  5. New treatments for renal and liver disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: In work under this licence we aim to identify new treatments for CKD, AKI and NAFLD. ... project? We hope to optimise new imaging efficacy endpoints that will allow assessment of animals over time.
  6. In vivo compressive forces (non-technical summary)_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf
    30 Apr 2024: For each stock a new generation will be grown every 18 months (3.3 generations per line in 5 years). ... For each we will breed a new generation every 18 months (2560x3.3=8448).
  7. Models of mitochondrial diseases, pathogenesis and therapy

    https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf
    30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx.
  8. Mechanisms controlling cell division and cell identity during…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_controlling_cell_division_and_cell_identity_during_development_reprogramming_and_disease_redacted.pdf
    30 Apr 2024: For example, understanding how cell identity can contribute to diseases may help in the discovery of new treatments. ... I am currently on the European Xenopus Resource Steering Committee where new developments in frog husbandry are often discussed.
  9. Understanding Infection Pathogenesis to Guide Therapies…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf
    30 Apr 2024: 6.1 million deaths annually (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). ... This is confounded by the fact that there have been very few new antimicrobial products that have been developed over the last 15 years.
  10. Mechanisms of organ development and disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_of_organ_development_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.
  11. Interaction between the immune system and tumours (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf
    30 Apr 2024: To the wider pharmaceutical industry and patients this could lead into the development of new anti-cancer therapies. ... Pilot studies are used to establish the correct dose of reagents/cells, timelines, and to generate baseline data for new experiments.

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