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Provision of an outsourced drug discovery platform for metabolic and…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_metabolic_and_cardiovascular_diseases_non-te_redacted.pdf30 Apr 2024: This project will generate important data in the preclinical development of potential new drugs for metabolic and cardiovascular disease. ... This will include investigation of any potential unwanted side effects that could be caused by the new drugs. -
Mechanisms underpinning neuronal excitability in health and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_underpinning_neuronal_excitability_in_health_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: Results will open avenues to developing new therapies to treat pain and neurodegeneration. ... Have regular discussions with the Named Persons and animal technicians within the facility to review current approaches and whether there are any new 3Rs -
Profiling of test agents in rodents in a drug discovery platform
https://www.ubs.admin.cam.ac.uk/system/files/public/profiling_of_test_agents_in_rodents_in_a_drug_discovery_platform_non-technical_summary_redacted.pdf30 Apr 2024: Ultimately, this project will contribute to the successful development of new drugs, which will benefit patients with the diseases being treated. ... make use of any new knowledge or better methods of performing animal studies. -
Remodelling of stem cells and niche cells from development and…
https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf30 Apr 2024: By disseminating our observations from early stages, for example via conferences, we create new collaborations with experts in research fields beyond our own. ... We will carry out pilot studies when new substances, radiation doses, or genetically -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf30 Apr 2024: least 5-10 new anti-cancer drugs using these models, or currently available models. ... Mice are the most common type of animal used for developing new cancer treatments. -
Cancer and its microenvironment! From mechanisms to translation…
https://www.ubs.admin.cam.ac.uk/system/files/public/cancer_and_its_microenvironment_from_mechanisms_to_translation_non-technical_summary_redacted.pdf30 Apr 2024: We are following this research field closely and will replace animal research where we can as new technologies develop and are tested and established. ... We also discuss with other groups doing similar research and have an open policy whereby new -
Interventions in pregnancy effects of obesity on maternal and…
https://www.ubs.admin.cam.ac.uk/system/files/public/interventions_in_pregnancy_effects_of_obesity_on_maternal_and_offspring_health_non-technical_summa_redacted.pdf30 Apr 2024: Furthermore, we have an extensive tissue bank of samples that can be utilised prior to generating new animal cohorts. ... Our group will attend termly facility user committee meetings where new information is disseminated. -
Environmental and placental contributions to pregnancy and life-long…
https://www.ubs.admin.cam.ac.uk/system/files/public/environmental_and_placental_contributions_to_pregnancy_and_life-long_health_non-technical_summary_redacted.pdf29 Apr 2024: activities including publications in magazines, news articles, blogs, and via twitter / social media feeds. ... We will perform pilot experiments, for e.g. to check the effectiveness of new therapies. -
Extrinsic regulation of haematopoietic stem and progenitor cells in…
https://www.ubs.admin.cam.ac.uk/system/files/public/extrinsic_regulation_of_haematopoietic_stem_and_progenitor_cells_in_health_disease_and_as_a_therape_1_redacted.pdf30 Apr 2024: However, the underlying reasons (which could offer new therapies) are only partially understood. ... might be doing regarding animal research and ensure our methods stay updated within the new refinements implemented by others. -
CNS Neuron-glia interactions, myelin plasticity, and regeneration, in …
https://www.ubs.admin.cam.ac.uk/system/files/public/cns_neuron-glia_interactions_myelin_plasticity_and_regeneration_in_health_and_disease_non-techni_redacted.pdf30 Apr 2024: The outputs of this licence will likely result in a new information and publications of the following:. ... With this knowledge gained we can identify new testable pathways for augmenting regeneration.
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