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Understanding the roles of autophagy and related pathways in…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_roles_of_autophagy_and_related_pathways_in_proteinopathies_non-technical_summary_redacted.pdf30 Apr 2024: There is an urgent need for new drugs and therapies to slow, delay and prevent proteinopathy diseases. ... Overall, we hope to identify new genes and compounds that allow us to better understand and manipulate neurodegeneration. -
Metabolic basis of microglia function in development (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf30 Apr 2024: Finally, full training will be provided to new technicians who are unfamiliar with these procedures. ... This will ensure that we maintain compliance should any new updates be posted. -
Pharmacological evaluation of imaging agents and development of…
https://www.ubs.admin.cam.ac.uk/system/files/public/pharmacological_evaluation_of_imaging_agents_and_development_of_imaging_applications_and_methods_no_redacted.pdf30 Apr 2024: As new molecular targets involved in diseases are discovered, the imaging agents that are required for imaging them need to be developed and evaluated in a manner similar to the drug ... When new drugs for removing these proteins are being developed it -
Determining mechanisms of tumour development and relapse following…
https://www.ubs.admin.cam.ac.uk/system/files/public/determining_mechanisms_of_tumour_development_and_relapse_following_treatment_non-technical_summary_redacted.pdf29 Apr 2024: On rare occasions, a new drug being tested can have unexpected adverse effects. ... Pilot studies will be employed when first attempting growth of a new source of human immune cells. -
Investigating the niche of mucosal parasitic nematodes and their…
https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_niche_of_mucosal_parasitic_nematodes_and_their_interactions_with_their_hosts_non_redacted.pdf30 Apr 2024: Knowledge generated from this work will open new avenues to eradicate whipworm and hookworm infections and control immune-mediated diseases. ... By the end of this project, we will have new information on the host-whipworm relationship, including (1) how -
Vaccine development and fundamental reseach on viruses of medical…
https://www.ubs.admin.cam.ac.uk/system/files/public/vaccine_development_and_fundamental_research_on_viruses_of_medical_importance_non-technical_summary_redacted.pdf29 Apr 2024: New knowledge will be disseminated in. PPL number: | Granted: 17 Feb 23 | Amended: 23 Aug 23 | Expires: 17 Feb 28. ... The majority of our vaccine studies can be considered "pilot studies" as we are measuring immune responses to new vaccines. -
Early life origins of heart disease in mammals (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/early_life_origins_of_heart_disease_in_mammals_non-technical_summary_redacted.pdf30 Apr 2024: Therefore, the proposed work in this new project licence may hasten translation to relatively simple but novel human clinical interventions to not only treat the mother, but also her progeny. ... Therefore, the project licence holder will have regular -
Genes and environment at the interface of inflammation, immunity and…
https://www.ubs.admin.cam.ac.uk/system/files/public/genes_and_environment_at_the_interface_of_inflammation_immunity_and_metabolism_non-technical_summa_redacted.pdf30 Apr 2024: We will generate new insight into the major biological processes underlying inflammatory diseases. ... This enables the development of new therapeutics, exploiting our discoveries. Species and numbers of animals expected to be used. -
Provision of an outsourced drug development platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_development_platform_for_the_treatment_of_bleeding_disorders_non-te_redacted.pdf30 Apr 2024: This project will provide important information that aids the progression of new drugs against bleeding disorders through the drug discovery and development process. ... for our studies and to identify any new and better methods that could be utilised. -
The genetic and developmental basis of morphological and behavioural…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_genetic_and_developmental_basis_of_morphological_and_behavioural_variation_in_cichlid_fishes_no_redacted.pdf30 Apr 2024: We will incorporate new recommendations on animal rearing and welfare as we have done up to now. ... We stay up-to-date with new information and new resources as they become available.
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