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Double spiral structure is unique to TDP-43 filament behind ALS and…
https://www2.mrc-lmb.cam.ac.uk/double-spiral-structure-is-unique-to-tdp-43-filament-behind-als-and-ftd-neurodegenerative-diseases/
16 Dec 2021:
A recent paper from Benjamin Ryskeldi-Falcon’s group reveals the first atomic structure of TDP-43 filaments from the brains of people with ALS and FTD
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Richard Henderson on his early career challenges, developing electron …
https://www2.mrc-lmb.cam.ac.uk/richard-henderson-on-his-early-career-challenges-developing-electron-microscopy-and-his-favourite-comic-books/
10 Jun 2021:
Group Leader Richard Henderson is a guest on The Microscopists podcast from Bitesize Bio. Here he chats with Peter O’Toole about a range of topics
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Following protein footprints on RNA to track splicing fidelity - MRC…
https://www2.mrc-lmb.cam.ac.uk/following-protein-footprints-on-rna-to-track-splicing-fidelity/
5 Mar 2021:
Erroneous splicing has been linked to at least 15% of human diseases, so understanding, at a molecular level, how splicing fidelity is maintained could lead to new treatments for these diseases.
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Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x73.html24 Aug 2021: set_default_temperature_factor_for_new_atoms() : c-interface.h. -
Spread of Delta SARS-CoV-2 variant driven by combination of immune…
https://www2.mrc-lmb.cam.ac.uk/spread-of-delta-sars-cov-2-variant-driven-by-combination-of-immune-escape-and-increased-infectivity/
14 Sep 2021:
Guido Papa and Anna Albecka-Moreau in the James lab contribute to University of Cambridge study, finding that Delta variant spike protein induces higher
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Strength of the powerlifting community helps put Camille Holland on…
https://www2.mrc-lmb.cam.ac.uk/strength-of-the-powerlifting-community-helps-put-camille-holland-on-the-path-to-the-world-championships/
6 Aug 2021:
Camille Holland, a member of the LMB’s Human Resources team, talks to the Cambridge Independent about powerlifting, the impact of lockdown stopping her
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Professional registration and awards: Celebrating the Technician’s…
https://www2.mrc-lmb.cam.ac.uk/professional-registration-and-awards-celebrating-the-technicians-commitment-at-the-lmb/
3 Dec 2021:
To support this the LMB is an active member of the Research Institute Technician Group and has also formed a new Technician Committee, led by Alison Lane, Head of Genotyping Services. ... I saw this as both a new challenge during Covid restrictions and
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Looking back: Maria Grazia Spillantini - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/share-your-memories/looking-back-maria-grazia-spillantini/
20 Dec 2021:
Looking back: Maria Grazia Spillantini Maria was a visiting scientist, PhD student and postdoctoral fellow in the LMB’s Director’s Division. She is now
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Advanced understanding of how suprachiasmatic nucleus regulates the…
https://www2.mrc-lmb.cam.ac.uk/advanced-understanding-of-how-suprachiasmatic-nucleus-regulates-the-bodys-circadian-rhythm/
9 Sep 2021:
Single-cell RNA sequencing analysis of over 30,000 suprachiasmatic nucleus cells by Michael Hastings’ group in the LMB’s Neurobiology Division has identified specific cell populations and highlighted the role of Prokineticinsignalling network to
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Florence Young is awarded the Raff PhD student Medal from the British …
https://www2.mrc-lmb.cam.ac.uk/florence-young-is-awarded-the-raff-phd-student-medal-from-the-british-society-for-cell-biology/
15 Dec 2021:
Florence Young, now a postdoc in Simon Bullock’s Lab, was recognised for her work linking neurodegenerative diseases to dysfunctional cell transportation.
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Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_func_0x73.html24 Aug 2021: set_default_temperature_factor_for_new_atoms() : c-interface.h. -
How immune responses differ between asymptomatic cases and people…
https://www2.mrc-lmb.cam.ac.uk/how-immune-responses-differ-between-asymptomatic-cases-and-people-with-severe-covid-19/
26 Apr 2021:
Understanding why different people have such varied experiences could be of great benefit to the development of new treatments and might enable prediction as to whether newly infected patients are more ... The study also suggests that it could also be
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Structural breakthrough in study of aggregated TDP-43 protein in…
https://www2.mrc-lmb.cam.ac.uk/structural-breakthrough-in-study-of-aggregated-tdp-43-protein-in-brains-of-als-and-ftd-sufferers/
8 Dec 2021:
Cryo-EM analysis of TDP-43 filaments by Benjamin Ryskeldi-Falcon’s group in the LMB’s Neurobiology Division has revealed the atomic structure of the characterising feature of neurodegenerative diseases ALS and FTD.
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TRIM21 is both enzyme and substrate when creating a signal to degrade …
https://www2.mrc-lmb.cam.ac.uk/trim21-is-both-enzyme-and-substrate-when-creating-a-signal-to-degrade-bound-viruses-and-proteins/
2 Mar 2021:
The intracellular immune receptor TRIM21 detects antibody-bound viruses inside our cells and targets them for destruction by creation of a polyubiquitin signal. David Neuhaus’ group, with Leo James’, has shown that TRIM21 is both the enzyme and
16 Dec 2021:
A recent paper from Benjamin Ryskeldi-Falcon’s group reveals the first atomic structure of TDP-43 filaments from the brains of people with ALS and FTD
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