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Blocking action of intestinal immune cell enhances the immune…
https://www2.mrc-lmb.cam.ac.uk/blocking-action-of-intestinal-immune-cell-enhances-the-immune-response-to-colorectal-cancer/7 Jun 2022: Andrew McKenzie’s group, in the LMB’s PNAC Division, has found a link between tumour-related expression of the IL25 gene, innate lymphoid cells and reduced survival amongst colorectal cancer patients -
LMB in vitro testing highlights bicyclic peptides (Bicycle®) as…
https://www2.mrc-lmb.cam.ac.uk/lmb-in-vitro-testing-highlights-bicyclic-peptides-bicycle-as-potential-antiviral-compounds-against-sars-cov-2/28 Apr 2022: Bicycle Therapeutics reports on its updated preclinical data produced in collaboration with Leo James’ group in the LMB’s PNAC Division. In vitro tests of -
Atomic structures of Aβ42 filaments from the brains of individuals…
https://www2.mrc-lmb.cam.ac.uk/atomic-structures-of-a%CE%B242-filaments-from-the-brains-of-individuals-with-alzheimers-disease-and-other-neurodegenerative-conditions/14 Jan 2022: The new structures differ from those previously determined using in vitro assembled Aβ42. -
LMB research featured in summary of three cryo-EM studies of TMEM106b …
https://www2.mrc-lmb.cam.ac.uk/lmb-research-featured-in-summary-of-three-cryo-em-studies-of-tmem106b-fibrils-found-in-neurodegenerative-diseases/13 Apr 2022: Alzforum summarises three recent papers which analysed TMEM106b amyloid filaments in the human brain – including research from Sjors Scheres’ and Michel -
Collaborative LMB study reveals S-shaped structure of Aβ42 filaments…
https://www2.mrc-lmb.cam.ac.uk/collaborative-lmb-study-reveals-s-shaped-structure-of-a%CE%B242-filaments-in-alzheimers-disease-and-other-neurodegenerative-diseases/20 Jan 2022: A recent structural study led by Sjors Scheres, Michel Goedert and Benjamin Ryskeldi-Falcon’s groups at the LMB has used cryo-EM to detect two main types -
Cryo-EM structure of a cholinergic cell membrane reveals importance…
https://www2.mrc-lmb.cam.ac.uk/cryo-em-structure-of-a-cholinergic-cell-membrane-reveals-importance-of-cholesterol-in-neuromuscular-transmission/22 Aug 2022: Structural study by Nigel Unwin in the LMB’s Neurobiology Division, has found that lipids of cell membranes can form ordered, hydrophobic ‘skins’ in regions of high cholesterol concentration. -
Salmonella and me: Emma Werner’s video on Salmonella infection in the …
https://www2.mrc-lmb.cam.ac.uk/salmonella-and-me-emma-werners-video-on-salmonella-infection-in-the-gut-is-a-top-10-finalist-in-nature-awards-science-in-shorts-competition/21 Jul 2022: Former PhD student, Emma Werner, from Felix Randow’s group, explains her 2021 Springer Nature journal publication on antibacterial cell-autonomous -
Greg Winter on innovation in science, his research on phage display…
https://www2.mrc-lmb.cam.ac.uk/greg-winter-on-innovation-in-science-his-research-on-phage-display-and-its-therapeutic-impact-and-winning-the-nobel-prize/30 Jun 2022: Roger Highfield, Science Director at the Science Museum, speaks to the LMB’s Greg Winter about his earliest scientific memories, how a road rage attack -
https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/downloads/protocols
https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/downloads/M4S_activities.pdf11 Mar 2022: Yeasts reproduce by budding (asexual reproduction), when a small bud forms and splits to form a new daughter cell, but under stress conditions they can produce spores (a form of sexual -
“Coot for SHELXL” Tutorial Paul Emsley & Judit É ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/coot-shelx.pdf27 Aug 2022: Select ValidateDifferenceMap Peaks. and hit Find blobs. [The new pop-up contains a clickable list of difference density blobs. ... 7. [We are given a new window to pick what kind of atom/molecule we wishto place here.]. -
Clinical study reveals striking daily temperature variation in the…
https://www2.mrc-lmb.cam.ac.uk/clinical-study-reveals-striking-daily-temperature-variation-in-the-human-brain-that-predicts-survival-after-brain-injury/13 Jun 2022: Beyond the clinic, these new data challenge scientists to review how human brain cells are grown and studied in the lab. -
Coot Tutorial CCP4 Summer School 2021 October 19, 2022 ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/tutorial.pdf19 Oct 2022: Coot adds new Buttons for the selected functions in the horizontal tool-bar]. • ... Click on an atom in the new ALA. [ Coot pops up a residue type chooser]. • -
Integrin-mediated T helper 2 cell clustering revealed as key step and …
https://www2.mrc-lmb.cam.ac.uk/integrin-mediated-t-helper-2-cell-clustering-revealed-as-key-step-and-potential-therapeutic-target-in-allergic-immune-response/22 Dec 2022: Researchers in Andrew McKenzie’s group, in the LMB’s PNAC Division, have used high-throughput CRISPR screening to identify a role for alpha V beta 3 integrin in IL-13 production which contributes to unwanted inflammation during an asthma or -
Structure of a cholinergic cell membraneNigel Unwina,1 Edited by ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnasS22.pdf4 Nov 2022: Science175, 720–731 (1972). 2. R. B. Gennis, Biomembranes: Molecular Structure and Function (Springer-Verlag New York Inc.,1989). ... Nat. New Biol. 236,11–12 (1972). 4. D. Branton, Fracture faces of frozen membranes. -
Human embryo research information
https://www2.mrc-lmb.cam.ac.uk/groups/shahbazi/wp-content/uploads/sites/30/Human-embryo-research-information.pdf22 Feb 2022: at the cellular level in the laboratory and potentially develop new drug treatments. ... Growing human embryos in a new culture system that permits correct development beyond implantation and up to day 13 of development1. -
Asgard archaea shed light on the evolutionary origins of the…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Hatano%20Nat%20Comms%202022.pdf13 Jun 2022: Nature Communications, doi:10.1038/s41467-022-30656-2 -
Mechanism of signal sequence handover from NAC to SRP on ribosomes…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Science_2022.pdf27 Feb 2022: 1200 New York Avenue NW, Washington, DC20005. The title Science is a registered trademark of AAAS.Copyright 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of -
The Biogenesis of Multipass Membrane Proteins
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/CSHL_Persp_2022.pdf13 Sep 2022: Here, we discuss the mechanisms of TMD insertion, highlight the limitations ofan iterative insertion model, and propose a new hypothesis for multipass membrane proteinbiogenesis based on recent findings. ... these new components were not ob-served on -
The Function, Structure, and Origins of the ER Membrane Protein…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Annual_Rev_Biochem_2022.pdf11 Apr 2022: Epistasis Maps Reveal New Protein Complexes. 8.52.2. EMC Is Linked to Membrane Protein Homeostasis. ... Second,surprisingly little new biological insight was immediately evident from simply seeing the structure,leaving one to speculate about EMC’s
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