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11 Dec 2001: the CATH (8) database but are much less extensive(http://www.biochem.ucl.ac.uk/bsm/cath_new/Gene3D). ... 1997) Gapped blast and psi-blast: a new generation of protein database search programs.

11 Dec 2001: the CATH (8) database but are much less extensive(http://www.biochem.ucl.ac.uk/bsm/cath_new/Gene3D). ... 1997) Gapped blast and psi-blast: a new generation of protein database search programs.

29 Oct 2001: Recent studies havedescribed this evolutionary mechanismin detail and show how mutations inactive site residues produce new catalyticproperties for enzymes4–7. ... J. Mol. Biol. 311, 693–708. 3 Jensen, R.A. (1976) Enzyme recruitment inevolution of

3 May 2001: more complex proteins haveevolved by the creation of the new protein families, or therecombination of existing families. ... This implies that in cre-ating new functions, nature more frequently combines oldbuilding blocks than inventing new ones.

25 Jun 2001: The underlying assumption is that Aand B have the chance to reshufe each time thereis a new combinatorial context. ... This impliesthat in creating new functions, nature has, overtime, combined more common building blockswith each other than

26 Oct 2001: A new procedure is described fordetecting and correcting those errors that arise at the model-buildingstage of the procedure. ... As well as giving assignments that can be usedin new investigations into genomes, they providepotential new annotations.

19 Aug 2001: 2001 Academic Press. 694 Evolution of Metabolic Pathways. active-site residues produce new catalytic proper-ties for enzymes and, hence, the formation of newpathways.8 11. ... Serialrecruitment would be expected if, for instance achunk of a chromosome,