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20 Aug 2021: Longer-term benefits will be opportunities for making new treatments for controlling fertility in humans.

19 Aug 2021: Understanding the mechanisms that control killing by these cells will improve the design of new immunotherapies. ... We will provide new information on pathways that are required by killer cells of the immune system.

13 Sep 2021: Longer-term benefits will be opportunities for making new treatments for controlling fertility in humans.

13 Sep 2021: The work will identify exactly how aneurysms develop and new treatments to prevent this. ... culture. Some aspects of disease including assessment of new treatments still require animal studies.

19 Aug 2021: It also allows for the initial testing of new treatment compounds to assess their compatibility. ... This enables the brain to make new circuits to bypass the damaged neurons.

13 Sep 2021: We will also be studying lung cancer. Nearly 45,000 new cases of lung cancer are diagnosed annually and nearly 35,000 people die from the disease in the UK every ... Our study aims to: 1) Increase the understanding of how types of breast and lung cancers

13 Sep 2021: However, we sometimes need to breed mice carrying particular genetic modifications to provide early embryos for short-term experiments or to generate new stem cell lines. ... Page 4 of 4. means that we require fewer embryo recipient females for creating

13 Sep 2021: Although stem cells in the brain can make new oligodendrocytes that restore myelin, this regenerative process declines with age. ... Our discoveries may be harnessed to develop new regenerative therapies in the treatment of MS.

20 Aug 2021: Work from this licence is likely to unravel new ways to manipulate the behaviour of these cells and inflammatory responses therapeutically. ... The key aspect of our programme is to visualise neutrophil behaviours in situ by advanced microscopy techniques

18 Jun 2021: This may be in the form of a new vaccine strategy, or a new anti-viral drug. ... Furthermore, to determine how effective new vaccine approaches are, experimental infections in mice are required.

13 Sep 2021: What's the aim of this project? After food consumption the gut sends signals to the rest of the body preparing it for the arrival of new nutrients. ... We constantly review the literature whilst planning our experiments and acclimatize animals to new

13 Sep 2021: Our research aims to understand the bases of these disorders, and develop new treatments for them. ... We also aim to use these models to develop new and better treatments for mental health disorders.

20 Aug 2021: Given how little innovation there is in veterinary medicine (compared to human medicine), this new class of drugs could have an even bigger impact on pet health than it did on ... In summary: Short-term benefit – New veterinary medicines based on what

20 Aug 2021: There is a pressing clinical need to identify new types of treatment for human disease (for example, the development of novel antibiotics) and engineered antibodies have considerable potential for this.

13 Sep 2021: Our research will study how and where the bacteria hide in the body to resist to vaccines and antibiotics and will test new innovative vaccines. ... impact of medical treatments and new vaccines on the behaviour of bacteria in an environment that closely

13 Sep 2021: The plan is to generate approximately 10 new models over the course of the licence. ... In this licence we will use lung tumour models to investigate new potential drugs for the treatment of lung cancer.

13 Sep 2021: For colorectal endoscopic courses, procedures may include a range of new surgical bowel procedures. ... For upper GI endoscopic courses procedures may include tonsillectomy, oesophageal, stomach, duodenal or pancreatic surgery, or other new appropriate

13 Sep 2021: To develop new drugs, it is first necessary to better understand how the nervous system works and what goes wrong in disease: enhanced understanding of how neurones work in health and ... With enhanced knowledge, our work will aid the development of new

19 Aug 2021: The treatments that come out of the project may be new intellectual property. ... Altogether, these will generate a blueprint for clinical studies, which will bring successful new treatments to patients.

19 Aug 2021: With all this information, new clinical trials can be designed that eventually may change clinical practice. ... They are also required by regulatory authorities before any trials of new drugs can be tested in humans.

19 Aug 2021: for pilot studies (https://www.nc3rs.org.uk/conducting-pilot-study);. ARRIVE guidelines, https://www.nc3rs.org.uk/arrive-guidelines;. IMPROVE guidelines for stroke models: ... I receive regular updates via the Biological Service of the University of

20 Aug 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Evaluation of new devices to be used in humansurgery. ... Also, getting new, effective devices/compounds into clinical use as quickly and safely as possible will maximise patient benefits and healthcare savings.

19 Aug 2021: These estimates will be updated and recalculated throughout the project as we generate new data.

20 Aug 2021: Importantly, we will study the relationship between the hippocampus (the area of the brain which acts as an internal GPS system and is crucial for remembering new events and navigating) and

20 Aug 2021: To avoid breeding new mouse strains we will investigate specific immune cells that are labelled.

19 Aug 2021: We hope this will help find new ways to treat or prevent brain disease. ... However, when we develop new techniques, we carefully consider the literature and seek expert advice before starting.

13 Sep 2021: We will perform pilot studies testing any new therapies in very small groups of normal mice. ... These new therapies will have already been tested in isolated cells in the laboratory.

19 Aug 2021: These papers will describe the development of a new type of bone repair material. ... the structure may be compromised, while if it too slow it may adversely affect new bone formation.

19 Aug 2021: basal skin layer, the productive life cycle is triggered and new viruses are produced; iv) PV is shed inside dead cells from the surface of. ... new insight into PV transmission mechanisms, and the development of anti-papillomavirus agents/treatments and

13 Sep 2021: What's the aim of this project? This project aims to discover and develop new ways to treat or prevent malaria transmission and disease. ... As such, the development of new anti-malaria blocking strategies is a major objective.

18 Jun 2021: Page 3 of 10. New genes of interest will be identified and described. ... Thus, finding new biomarkers improves our ability to both detect and treat cancer.

18 Jun 2021: The new insights gained could lead to new strategies for treating such disorders, including learning disabilities and Alzheimer's disease. ... Moreover, our institution's web pages provide regular updates on new developments in the 3Rs.

18 Jun 2021: This network will be utilised to maximise the dissemination of the new knowledge gained through this project. ... 3) By generating large quantities of human cells, where appropriate, we can continue to perform new studies using the same human cells.

13 Sep 2021: The research will aid in the development of new bacterial therapies to treat cancer. ... We continuously consider their use and development in light of new experimental data.

18 Jun 2021: The work will;. 1. Provide new insights into the mechanisms required for regeneration. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

13 Sep 2021: This second part will provide new hypotheses and research avenues for future research projects about mitochondrial and neurodegenerative diseases. ... Data generated from this project will form the basis for new funding applications, and may eventually

13 Sep 2021: In order to produce new mouse colonies a minority of germ-free mice will be given mammalian gut bacteria orally to produce gnotobiotic mice with a known gut flora (bacteria).

13 Sep 2021: The new insights gained could lead to new strategies for treating such disorders, including learning disabilities and Alzheimer's disease. ... Moreover, our institution's web pages provide regular updates on new developments in the 3Rs.

18 Jun 2021: This project will likely result in new information and publications about the following:. ... In recent years scientists have developed a new way of growing (culturing) cells in 3 dimensions.

18 Jun 2021: tolerance, providing new information on how the genes under investigation impact human metabolism and health. ... or 'negative' in the same way that a trial of a new treatment would be.

19 Aug 2021: The long-term goal of this research is to discover new mechanisms controlling the growth of nerve cells.

13 Sep 2021: Our investigations and the data generated are expected to lead to new collaborations with other researchers. ... We will incorporate new recommendations on animal welfare, as soon as possible after their publication.

18 Jun 2021: We aim to develop new approaches to treatment that target the pathways identified from human genetic studies. ... We will disseminate new knowledge and findings by publishing our results in internationally recognised scientific journals.

13 Sep 2021: However, our understanding of how this happens is still limited, and this has prevented scientists from finding new effective treatments. ... Our results will therefore benefit the scientific community through the provision of important new knowledge

13 Sep 2021: Chiefly, outputs will include generation of new knowledge, which will be timely and freely disseminated as publications in open-access journals, full datasets, and conference presentations. ... Before behavioural testing, mice will be acclimatised to the

18 Jun 2021: We expect to test new compounds that inhibit alpha-synuclein aggregation into clumps and spreading to delay the development of pathology. ... Several collaborations are in place and will be developed to obtain new tools to further the understanding of

13 Sep 2021: All new information will be presented at scientific conferences and published as peer-reviewed research articles. ... When repeated or prolonged interventions are required, animals will be acclimitised to new environments (e.g.

18 Jun 2021: We are using new-born mice to collect cells to grow and keep in a dish to do experiments. ... provide additional sources of new recommendations and advances in animal techniques and clinically applicable models.

19 Aug 2021: Animals from these new lines will be used to generate eggs by natural spawning. ... In the case of new chemicals, pilot experiments will be used to test chemical toxicity.

13 Sep 2021: The work will;. 1. Provide new insights into the mechanisms required for regeneration. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.