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  2. LMB’s Challenge Project with Cambridge Academy for Science and…

    https://www2.mrc-lmb.cam.ac.uk/lmbs-challenge-project-with-cambridge-academy-for-science-and-technology/
    Thumbnail for LMB’s Challenge Project with Cambridge Academy for Science and Technology - MRC Laboratory of Molecular Biology 23 Mar 2018: Theo, one of the students who participated in the Challenge Project, said the project “opened up new career ideas and broadened my horizons”.
  3. Silent tuberculosis is less common than had been widely thought - MRC …

    https://www2.mrc-lmb.cam.ac.uk/silent-tuberculosis-is-less-common-than-had-been-widely-thought/
    Thumbnail for Silent tuberculosis is less common than had been widely thought - MRC Laboratory of Molecular Biology 24 Sep 2018: A study by Lalita Ramakrishnan, from the University of Cambridge Molecular Immunity Unit based in the LMB, has found that most people who fall seriously
  4. The winner of the 2018 LMB’s schools Science Image Award is… - MRC…

    https://www2.mrc-lmb.cam.ac.uk/the-winner-of-the-2018-lmbs-schools-science-image-award-is/
    Thumbnail for The winner of the 2018 LMB’s schools Science Image Award is… - MRC Laboratory of Molecular Biology 13 Jul 2018: Thirteen primary schools from Cambridge and the surrounding area have participated in this year’s Science Image Award.  The competition, part of the LMB’s
  5. Ana Casañal awarded Biochemical Society Early Career Research Award.…

    https://www2.mrc-lmb.cam.ac.uk/ana-casanal-awarded-biochemical-society-early-career-research-award/
    Thumbnail for Ana Casañal awarded Biochemical Society Early Career Research Award. - MRC Laboratory of Molecular Biology 4 Apr 2018: Ana Casañal from the LMB’s Structural Studies Division has been awarded the prestigious Biochemical Society Early Career Research Award 2019 for Genes.
  6. REFMAC5 Tutorial - Part 2

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/refmac_tutorial/files/part_2.html
    23 Jun 2018: Show Me This. A new job will be created. The main inputs may already be populated with data from a previous job, in which case select "No" from the "Use data ... This will create a new job, pre-populated with the inputs from the previous job.
  7. LMB showcases the diversity of science at the Cambridge Science…

    https://www2.mrc-lmb.cam.ac.uk/lmb-showcases-the-diversity-of-science-at-the-cambridge-science-festival/
    Thumbnail for LMB showcases the diversity of science at the Cambridge Science Festival - MRC Laboratory of Molecular Biology 28 Mar 2018: New for the 2018 Guildhall event, members of the public could pop into the special science booth to chat to the scientists about their research. ... His talk looked at the exciting work in the field of structural biology, tracing the beginnings of the
  8. Johannes Kohl wins the 2018 Eppendorf & Science Prize for…

    https://www2.mrc-lmb.cam.ac.uk/johannes-kohl-wins-the-2018-eppendorf-science-prize-for-neurobiology/
    Thumbnail for Johannes Kohl wins the 2018 Eppendorf & Science Prize for Neurobiology - MRC Laboratory of Molecular Biology 17 Oct 2018: Johannes Kohl, a former PhD student from Greg Jefferis’ group in the LMB’s Neurobiology division, is the grand prize winner in The Eppendorf & Science
  9. From Backbench to Lab Bench: LMB welcomes visitors from Westminster - …

    https://www2.mrc-lmb.cam.ac.uk/from-backbench-to-lab-bench-lmb-welcomes-visitors-from-westminster/
    Thumbnail for From Backbench to Lab Bench: LMB welcomes visitors from Westminster - MRC Laboratory of Molecular Biology 17 Apr 2018: Daniel Zeichner MP for Cambridge, and Nancy Bailey and Rebecca Nohl from the Government Office for Science, swapped policy and debate for lab coats and
  10. Alcohol can cause irreversible genetic damage to stem cells, says…

    https://www2.mrc-lmb.cam.ac.uk/alcohol-can-cause-irreversible-genetic-damage-stem-cells-says-study/
    Thumbnail for Alcohol can cause irreversible genetic damage to stem cells, says study - MRC Laboratory of Molecular Biology 5 Jan 2018: Link between drinking and cancer clarified by study - led by KJ Patel’s group in the LMB’s PNAC Division - which indicates alcohol causes cancer by
  11. Making the undruggable druggable: the first platform to discover…

    https://www2.mrc-lmb.cam.ac.uk/making-the-undruggable-druggable-the-first-platform-to-discover-selective-phosphatase-inhibitors/
    Thumbnail for Making the undruggable druggable: the first platform to discover selective phosphatase inhibitors - MRC Laboratory of Molecular Biology 26 Jul 2018: New method identifies a selective inhibitor of PPP1R15B, a potential target for Huntington’s disease. ... This novel approach may pave the way to a new therapeutic strategy for such diseases.
  12. REFMAC5 Tutorial - Part 1

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/refmac_tutorial/files/part_1.html
    23 Jun 2018: Open the CCP4i2 GUI, and create a new project as appropriate. ... This will create a new job (Job 3), which will allow the refined model and density to be displayed using Coot.
  13. REFMAC5/ProSMART Tutorial

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/refmac_tutorial/files/part_4.html
    23 Jun 2018: This will create a new job, pre-populated with the inputs from the previous job. ... This will create a new job, which will allow the refined model and density to be displayed using Coot.
  14. REFMAC5 Tutorial - Part 3

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/refmac_tutorial/files/part_3.html
    23 Jun 2018: Show Me This. A new job will be created. The main inputs may already be populated with data from a previous job, in which case select "No" from the "Use data ... This will create a new job, pre-populated with the inputs from the previous job.
  15. For difficult-to-model brain diseases, brain organoids come to the…

    https://www2.mrc-lmb.cam.ac.uk/for-difficult-to-model-brain-diseases-brain-organoids-come-to-the-rescue/
    Thumbnail for For difficult-to-model brain diseases, brain organoids come to the rescue - MRC Laboratory of Molecular Biology 22 Nov 2018: The LMB’s Madeline Lancaster spoke to the Journal of the American Medical Association (JAMA) about her work on brain organoids and their potential future
  16. Twelfth annual LMB CamAWiSE “What Next For Your Career In Science?”…

    https://www2.mrc-lmb.cam.ac.uk/twelfth-annual-lmb-camawise-what-next-for-your-career-in-science-event/
    Thumbnail for Twelfth annual LMB CamAWiSE “What Next For Your Career In Science?” event - MRC Laboratory of Molecular Biology 14 Jun 2018: At each of her career transitions Tanita brought transferable skills into her new role, and she advised attendees applying for jobs not to think about what they have done, but about
  17. Scientists identify exoplanets where life could develop as it did on…

    https://www2.mrc-lmb.cam.ac.uk/scientists-identify-exoplanets-where-life-could-develop-as-it-did-on-earth/
    Thumbnail for Scientists identify exoplanets where life could develop as it did on Earth - MRC Laboratory of Molecular Biology 2 Aug 2018: The new study proposes that stars which give off sufficient ultraviolet (UV) light could kick-start life on their orbiting planets in the same way it likely developed on Earth, where ... This new work is the result of an ongoing collaboration between
  18. HIV exploits a native cellular molecule to increase the stability of…

    https://www2.mrc-lmb.cam.ac.uk/hiv-exploits-a-native-cellular-molecule-to-increase-the-stability-of-its-capsid/
    Thumbnail for HIV exploits a native cellular molecule to increase the stability of its capsid - MRC Laboratory of Molecular Biology 31 May 2018: Scientists in Leo James’ group in the LMB’s PNAC Division, in collaboration with Till Böcking’s group at the University of New South Wales, Australia and Adolfo Saiardi’s group ... 6 . match the six positively charged residues in the pore. By
  19. Greg Jefferis awarded Francis Crick Medal and Lecture by the Royal…

    https://www2.mrc-lmb.cam.ac.uk/greg-jefferis-awarded-francis-crick-medal-and-lecture-by-the-royal-society/
    Thumbnail for Greg Jefferis awarded Francis Crick Medal and Lecture by the Royal Society - MRC Laboratory of Molecular Biology 19 Jul 2018: Greg Jefferis, group leader in the LMB’s Neurobiology Division, has been awarded the Francis Crick Medal and Lecture 2019 in recognition of his
  20. From PhD to policy – James Wagstaff completes an internship with the…

    https://www2.mrc-lmb.cam.ac.uk/from-phd-to-policy-james-wagstaff-completes-an-internship-with-the-hm-courts-and-tribunals-service/
    Thumbnail for From PhD to policy – James Wagstaff completes an internship with the HM Courts and Tribunals Service - MRC Laboratory of Molecular Biology 4 May 2018: a new corruption reporting portal. ... I’m returning to my PhD with a new perspective on my work and my future – this was an immensely valuable experience.”.
  21. Parkin activation and early-onset Parkinson’s disease: the last piece …

    https://www2.mrc-lmb.cam.ac.uk/parkin-activation-and-early-onset-parkinsons-disease-the-last-piece-of-the-puzzle/
    Thumbnail for Parkin activation and early-onset Parkinson’s disease: the last piece of the puzzle - MRC Laboratory of Molecular Biology 7 Jun 2018: disease. Led by David Komander’s group in the LMB’s PNAC Division, in collaboration with the LMB’s Biological Mass Spectrometry facility, this new work reveals insights into previously unstudied ... Christina’s work also identified a new class of
  22. Lori Passmore hands on her Suffrage Science accolade to LMB alumnus…

    https://www2.mrc-lmb.cam.ac.uk/lori-passmore-hands-on-her-suffrage-science-accolade-to-lmb-alumnus-rebecca-voorhees/
    Thumbnail for Lori Passmore hands on her Suffrage Science accolade to LMB alumnus Rebecca Voorhees - MRC Laboratory of Molecular Biology 12 Jun 2018: Suffrage Science award-holders, old and new. Primary Sidebar. Search. Search this website.
  23. Nicola Smyllie joins forces with artist Dilek Özgit for Soapbox…

    https://www2.mrc-lmb.cam.ac.uk/nicola-smyllie-joins-forces-with-artist-dilek-ozgit-for-soapbox-science-at-strawberry-fair/
    Thumbnail for Nicola Smyllie joins forces with artist Dilek Özgit for Soapbox Science at Strawberry Fair - MRC Laboratory of Molecular Biology 6 Jun 2018: This year’s Cambridge Soapbox Science took on a new dimension with scientists partnered with artists with the aim of bringing difficult science concepts to the public in exciting, innovative and ... It was amazing to then see my research incorporated
  24. Electron cryo-microscopy reveals near-atomic resolution structure of…

    https://www2.mrc-lmb.cam.ac.uk/cryo-electron-microscopy-reveals-near-atomic-resolution-structure-of-the-prespliceosome/
    Thumbnail for Electron cryo-microscopy reveals near-atomic resolution structure of the prespliceosome - MRC Laboratory of Molecular Biology 12 Jul 2018: Kiyoshi Nagai’s group in the LMB’s Structural Studies Division have used electron cryo-microscopy to solve the structure of the prespliceosome at near-atomic resolution, providing new insights into ... New work from Kiyoshi’s group has now used
  25. ProSHADE: src/bin/bin.cpp Source File

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/proshade/doxygen/d2/db3/bin_8cpp_source.html
    1 Nov 2018: 911 ProSHADE::ProSHADE_settings setUp = new ProSHADE::ProSHADE_settings ( );. 912. ... 1023 ProSHADE::ProSHADE proshadeObj = new ProSHADE::ProSHADE ( setUp );. 1024.
  26. How neuropeptide signalling controls sensitisation in response to…

    https://www2.mrc-lmb.cam.ac.uk/how-neuropeptide-signalling-controls-sensitisation-in-response-to-touch-in-c-elegans/
    Thumbnail for How neuropeptide signalling controls sensitisation in response to touch in C. elegans - MRC Laboratory of Molecular Biology 24 Aug 2018: New research from Bill Schafer’s group in the LMB’s Neurobiology Division has identified how sensitisation occurs to control various behavioural states in C.
  27. Alexey Amunts’ group at Stockholm University determine the structure…

    https://www2.mrc-lmb.cam.ac.uk/alexey-amunts-group-at-stockholm-university-determine-the-structure-of-the-chlororibosome/
    Thumbnail for Alexey Amunts’ group at Stockholm University determine the structure of the chlororibosome - MRC Laboratory of Molecular Biology 11 Apr 2018: This work reveals unexpected insights into this central protein synthesis machinery in plants and provides a new perspective for the investigation of the evolution of translation and its regulation.
  28. How flat sheets of cells become tubular organs: observing cellular…

    https://www2.mrc-lmb.cam.ac.uk/how-flat-sheets-of-cells-become-tubular-organs-observing-cellular-dynamics-from-2d-to-3d/
    Thumbnail for How flat sheets of cells become tubular organs: observing cellular dynamics from 2D to 3D - MRC Laboratory of Molecular Biology 3 Aug 2018: New research from Katja Röper’s group in the LMB’s Cell Biology Division, in collaboration with Guy Blanchard at the Department of Physiology, Development and Neuroscience at the University of ... In the rest of the tissue, cells were tilted towards
  29. The structure of retromer: a molecular machine packing cargo at the…

    https://www2.mrc-lmb.cam.ac.uk/the-structure-of-retromer-a-molecular-machine-packing-cargo-at-the-cells-logistics-hub/
    Thumbnail for The structure of retromer: a molecular machine packing cargo at the cell’s logistics hub - MRC Laboratory of Molecular Biology 18 Sep 2018: This new model of the complex allows for a greater understanding of the ways in which the components interact with each other and also demonstrated how retromer might interact with other ... This new structure and the new understanding of the role of
  30. MD1-118 Hippocrates additive screen

    https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/Addit-03.pdf
    9 Jul 2018: The Hippocrates Additive Screen is a new 48-condition additive screen, containing a library of unique drug-like compounds to enhance protein stability and crystallisability.
  31. Next generation sequencing and machine learning provide insights into …

    https://www2.mrc-lmb.cam.ac.uk/next-generation-sequencing-and-machine-learning-provide-insights-into-the-dark-proteome/
    Thumbnail for Next generation sequencing and machine learning provide insights into the dark proteome - MRC Laboratory of Molecular Biology 14 May 2018: This new research and IDR-Screen developed by Madan’s group represents an important advance as this technology allows for the discovery and characterisation of biologically and functionally relevant disordered regions
  32. ProSHADE: src/proshade/ProSHADE_legendre.h Source File

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/proshade/doxygen/d3/dad/_pro_s_h_a_d_e__legendre_8h_source.html
    1 Nov 2018: 190 abscSteps = new double [taylorSeriesCap2];. ... 191 weightSteps = new double [taylorSeriesCap1];.
  33. From marketing to logistics to speakers: LMB scientists take part in…

    https://www2.mrc-lmb.cam.ac.uk/from-marketing-to-logistics-to-speakers-lmb-scientists-take-part-in-cambridge-pint-of-science/
    Thumbnail for From marketing to logistics to speakers: LMB scientists take part in Cambridge Pint of Science - MRC Laboratory of Molecular Biology 4 Jun 2018: Twelve LMB scientists, from PhD student to Group Leader, have taken part in this year’s Cambridge Pint of Science, an annual festival that brings
  34. ProSHADE: src/proshade/ProSHADE_wigner.cpp Source File

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/proshade/doxygen/d6/d59/_pro_s_h_a_d_e__wigner_8cpp_source.html
    1 Nov 2018: exponentGammaReal = new double[static_cast<unsigned int> ( 2 this->_bandwidthLimit - 1 )];. 117 double exponentGammaImag = new double[static_cast<unsigned int> ( 2 this->_bandwidthLimit - 1 )];. 118. ... localComparisonBandLim - 1 )];. 283 double
  35. Joan Argetsinger Steitz wins the 2018 Lasker-Koshland Special…

    https://www2.mrc-lmb.cam.ac.uk/joan-argetsinger-steitz-wins-the-2018-lasker-koshland-special-achievement-award-in-medical-science/
    Thumbnail for Joan Argetsinger Steitz wins the 2018 Lasker-Koshland Special Achievement Award in Medical Science - MRC Laboratory of Molecular Biology 13 Sep 2018: Joan Argetsinger Steitz, a former post-doctoral researcher at the LMB, has been awarded the 2018 Lasker-Koshland Special Achievement Award in Medical
  36. ProSHADE: src/proshade/ProSHADE_lapack.cpp Source File

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/proshade/doxygen/d7/dee/_pro_s_h_a_d_e__lapack_8cpp_source.html
    1 Nov 2018: 59 std::complex<double> matrixToDecompose = new std::complex<double>[dimdim];. ... 132 std::complex<double> matrixToDecompose = new std::complex<double>[dimdim];.
  37. Clemens Plaschka wins the 2018 Walther Flemming Award from the German …

    https://www2.mrc-lmb.cam.ac.uk/clemens-plaschka-wins-the-2018-walther-flemming-award-from-the-german-society-for-cell-biology/
    Thumbnail for Clemens Plaschka wins the 2018 Walther Flemming Award from the German Society for Cell Biology - MRC Laboratory of Molecular Biology 23 Aug 2018: Clemens Plaschka, a former post-doctoral researcher in Kiyoshi Nagai’s group in the LMB’s Structural Studies Division, has won the 2018 Walther Flemming
  38. Children enjoy an afternoon of discussing science books and hands-on…

    https://www2.mrc-lmb.cam.ac.uk/children-enjoy-an-afternoon-of-discussing-science-books-and-hands-on-experiments-with-lmb-postdocs/
    Thumbnail for Children enjoy an afternoon of discussing science books and hands-on experiments with LMB postdocs - MRC Laboratory of Molecular Biology 20 Sep 2018: A group of 17 children joined postdocs from the LMB and the Department of Biochemistry to review science books, learn more about what it’s really like to
  39. MD1-93 the Morpheus Additive Screen

    https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/Addit-01.pdf
    5 Jul 2018: The Morpheus Additive Screen is a new 96-condition additive screen, containing an extensive library of ligands suitable for soluble and membrane proteins.
  40. Alexey Amunts is appointed Head of the program for Biology of…

    https://www2.mrc-lmb.cam.ac.uk/alexey-amunts-is-appointed-head-of-the-program-for-biology-of-molecular-interactions-by-scilifelab/
    Thumbnail for Alexey Amunts is appointed Head of the program for Biology of Molecular Interactions by SciLifeLab - MRC Laboratory of Molecular Biology 29 Jun 2018: Science for Life Laboratory (SciLifeLab) is a collaboration hub for the top research institutions in Sweden, providing the country’s largest life sciences
  41. Alzheimer's disease will become manageable like HIV, says Michel…

    https://www2.mrc-lmb.cam.ac.uk/alzheimers-disease-will-become-manageable-like-hiv-says-michel-goedert-fellow-brain-prize-2018-winners/
    Thumbnail for Alzheimer's disease will become manageable like HIV, says Michel Goedert and fellow Brain Prize 2018 winners - MRC Laboratory of Molecular Biology 8 Mar 2018: 2018 Brain Prize winner Michel Goedert, group leader in the LMB Neurobiology Division, who discovered the importance of tau protein in Alzheimer's said he
  42. Meet our worms!Our worms have a long name: Caenorhabditis ...

    https://www2.mrc-lmb.cam.ac.uk/groups/worms/download/Meet-our-worms_worksheet.pdf
    18 Jan 2018: For example, we can introduce new DNA (i.e. make transgenic animals), to express fluorescent proteins in our cells of interest, or we can silence genes to find out what they
  43. tutorial.dvi

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/newt.pdf
    18 Jun 2018: Coot adds intermediate white atoms and pops up a dialog]. • Accept the new atoms. ... Click on an atom in the new ALA. [Coot pops up a residue type chooser]. •
  44. Venki Ramakrishnan talks about the impact of Greg Winter’s Nobel…

    https://www2.mrc-lmb.cam.ac.uk/venki-ramakrishnan-talks-about-the-impact-of-greg-winters-nobel-prize-winning-research-on-bbc-world-service/
    Thumbnail for Venki Ramakrishnan talks about the impact of Greg Winter’s Nobel Prize-winning research on BBC World Service - MRC Laboratory of Molecular Biology 11 Oct 2018: In a segment about this year’s Chemistry Nobel Prize, Venki Ramakrishnan talks to Roland Pease on BBC World Service’s Science in Action about the impact
  45. We use cookies to help us provide the best ...

    https://www2.mrc-lmb.cam.ac.uk/archive/articles/Potassium_is_critical_to_circadian_rhythms.pdf
    18 Jan 2018: Featuring. Dr Fatima LabeedSenior Lecturer in Human Biology. Follow us @unisurreynews [https://twitter.com/unisurreynews]. Latest news stories RSS feeds [https://www.surrey.ac.uk/gateway/rss/rss.xml]. ... Related subjects. Related news and features.
  46. ProSHADE: ProSHADE_internal::ProSHADE_distances Class Reference

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/proshade/doxygen/d1/d6f/class_pro_s_h_a_d_e__internal_1_1_pro_s_h_a_d_e__distances.html
    1 Nov 2018: Therefore, if one wants to change the settings, new database needs to be build.
  47. MD1-91, MD1-92 and MD1-92-FX Morpheus II 10 mL, HT-96 and FX-96…

    https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB20.pdf
    9 Jul 2018: Some additives such as metal divalent cations can induce new crystal contacts. ... New polyols included for cryoprotection of conditions: no need to investigate more conditions for cryo-cooling. •
  48. Jan Löwe talks with the Cambridge Independent about his group’s…

    https://www2.mrc-lmb.cam.ac.uk/jan-lowe-talks-with-the-cambridge-independent-about-his-groups-research-and-development-of-the-cambridge-biomedical-campus/
    Thumbnail for Jan Löwe talks with the Cambridge Independent about his group’s research and development of the Cambridge Biomedical Campus - MRC Laboratory of Molecular Biology 19 Dec 2018: Jan Löwe describes his group’s research on the bacterial cytoskeleton and its importance in the fight against antimicrobial resistance. More...
  49. Jan Löwe talks with the Cambridge Independent about leading the LMB…

    https://www2.mrc-lmb.cam.ac.uk/jan-lowe-talks-with-the-cambridge-independent-about-leading-the-lmb-and-the-next-frontier-for-the-laboratory/
    Thumbnail for Jan Löwe talks with the Cambridge Independent about leading the LMB and the next frontier for the laboratory - MRC Laboratory of Molecular Biology 13 Dec 2018: Jan Löwe describes how a long-term vision has had such success for the LMB and how such an approach could be used by LMB scientists to map the brain.
  50. Stable research funding drives Britain’s ‘Nobel factory’ – The…

    https://www2.mrc-lmb.cam.ac.uk/stable-research-funding-drives-britains-nobel-factory-the-financial-times-looks-into-the-lmbs-formula-for-scientific-success/
    Thumbnail for Stable research funding drives Britain’s ‘Nobel factory’ – The Financial Times looks into the LMB’s formula for scientific success - MRC Laboratory of Molecular Biology 10 Dec 2018: Jan Löwe, Director of the LMB, LMB Nobel laureates Richard Henderson and Greg Winter, and other LMB scientists, tell the Financial Times the secrets
  51. Instinctive and learned responses to smells are controlled by a…

    https://www2.mrc-lmb.cam.ac.uk/instinctive-and-learned-responses-to-smells-are-controlled-by-a-single-brain-circuit-in-flies/
    Thumbnail for Instinctive and learned responses to smells are controlled by a single brain circuit in flies - MRC Laboratory of Molecular Biology 20 Sep 2018: As well as having instinctive responses to their environment, nearly all animals can learn to associate particular sights, smells, or sounds with rewards

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