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A new way to mark bacterial invaders for destruction - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/a-new-way-to-mark-bacterial-invaders-for-destruction/19 May 2021: Search this website. A new way to mark bacterial invaders for destruction. ... A new way to mark bacterial invaders for destruction. Published on. -
A new 2D protein material for studying receptor endocytosis - MRC…
https://www2.mrc-lmb.cam.ac.uk/a-new-2d-protein-material-for-studying-receptor-endocytosis/6 Jan 2021: The fields of artificial biology and biomaterial engineering aim to take advantage of these functions and manipulate proteins so that they have new capabilities. ... This new material could therefore be of benefit to immunotherapy by blocking receptor -
Classification of human tauopathies based on tau filament folds - MRC …
https://www2.mrc-lmb.cam.ac.uk/classification-of-human-tauopathies-based-on-tau-filament-folds/29 Sep 2021: Moreover, this method provides new ways for studying the similarities and differences between diseases. ... This new classification complements the previous clinical diagnostic and neuropathological approaches, and allows for the identification of new -
LMB’s new exhibition room is officially open - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/lmbs-new-exhibition-room-is-officially-open/1 Jul 2021: Search this website. LMB’s new exhibition room is officially open. LMB’s new exhibition room is officially open. ... supporting the Max Perutz Lecture Theatre above, which needed to remain undisturbed and incorporated into the new design. -
Targeting RNA replication in SARS-CoV-2 - MRC Laboratory of Molecular …
https://www2.mrc-lmb.cam.ac.uk/targeting-rna-replication-in-sars-cov-2/3 Feb 2021: The polymerisation assays indicated that favipiravir-RTP is only weakly incorporated into a new RNA strand, but nonetheless suppresses RNA replication by acting as a competitive inhibitor of GTP. ... Either of these are important potential directions to -
Coot Scripting Interface: c-interface.h File Reference
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/c-interface_8h.html24 Aug 2021: void . set_molecule_name (int imol, const char new_name). set the molecule name of the imol-th molecule. ... Return -1 on failure to make an averaged map, otherwise return the new map molecule number. -
Scaling-up grid manufacture to solve bottleneck in cryo-EM - MRC…
https://www2.mrc-lmb.cam.ac.uk/scaling-up-grid-manufacture-to-solve-bottleneck-in-cryo-em/3 Nov 2021: New grid has the potential to ease bottleneck on demand, keeping ‘fuel’ in microscopes. ... Now, due to this new large-scale method for making the grids, HexAuFoil grids will become accessible to everyone in the cryo-EM field. -
Understanding TRIM21 activation allows Trim-Away toolbox expansion -…
https://www2.mrc-lmb.cam.ac.uk/understanding-trim21-activation-allows-trim-away-toolbox-expansion/9 Mar 2021: Leo’s group has now exploited new understanding of Trim-Away’s mechanism of activation to expand the technology’s toolbox. -
Linda Amos (1943 - 2021) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/linda-amos-1943-2021/26 Feb 2021: Linda Amos, former Group Leader in the LMB’s Structural Studies Division, died on Sunday 21st February 2021. Linda was an excellent electron microscopist, at the forefront of image analysis and reconstruction. -
Ben Nichols - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/ben-nichols/30 Mar 2021: Ben Nichols Ben Nichols first joined the LMB’s Cell Biology Division in 1996, as a postdoctoral scientist in Hugh Pelham’s group, working on yeast -
New structures show how auxiliary subunits modulate hippocampal AMPA…
https://www2.mrc-lmb.cam.ac.uk/new-structures-show-how-auxiliary-subunits-modulate-hippocampal-ampa-receptor-neurotransmission/2 Jun 2021: Search this website. New structures show how auxiliary subunits modulate hippocampal AMPA receptor neurotransmission. ... New structures show how auxiliary subunits modulate hippocampal AMPA receptor neurotransmission. -
Biogrpahical
https://www2.mrc-lmb.cam.ac.uk/groups/rh15/Biographical.html14 Apr 2021: LMB also continues to develop techniques and methods alongside tackling challenging new scientific problems. -
Briggs SARS-CoV-2 Image - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/download/briggs-nature-cover/31 Mar 2021: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Downloads -
Testing the capacity for intracellular antibodies to neutralise…
https://www2.mrc-lmb.cam.ac.uk/testing-the-capacity-for-intracellular-antibodies-to-neutralise-sars-cov-2/29 Jul 2021: Leo James’ group, in the LMB’s PNAC Division, has developed a new assay that can measure the anti-viral activity of anti-N antibodies in blood samples. ... how many new virions are produced or quantifying the amount of viral RNA present. -
“The LMB provides an unsurpassed environment for both new ...
https://www2.mrc-lmb.cam.ac.uk/?wpdmdl=1885218 Jan 2021: cell type that controls the start of allergic asthma, providing a critical first step in developing new. ... to solve the structureof the ribosome and is. informing work to develop new antibiotics. -
Brian Hartley (1926 – 2021) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/brian-hartley-1926-2021/7 May 2021: rd. May 2021. Brian made outstanding contributions to protein chemistry, with his invention of new analytical methods, and produced for the first time an understanding of the properties of proteolytic enzymes ... Brian continued his work on the sequence -
Evolutionary journey of mycobacteria mapped - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/evolutionary-journey-of-mycobacteria-mapped/30 Apr 2021: the new virulent clones of M. ... abscessus, and prevent the emergence of new ones. Without this, it is likely that increased opportunities for direct transmission of pathogenic mycobacteria – because of factors such as rising population density or -
Coot Scripting Interface: c-interface-generic-objects.h File Reference
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/c-interface-generic-objects_8h.html24 Aug 2021: new_generic_object_number (const std::string &obj_name). create a new generic object with name objname More.. ... int new_generic_object_number. (. const std::string &. obj_name. ). create a new generic object with name objname. -
Browse the photo archive - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/photographs/browse-all/31 Mar 2021: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Browse -
Covid19 Image - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/download/covid19-image-download/30 Mar 2021: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Downloads -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x6e.html24 Aug 2021: new_generic_object_number_for_molecule() : c-interface-generic-objects.h. ... new_molecule_by_symmetry_with_atom_selection() : c-interface.h. -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_func_0x6e.html24 Aug 2021: new_generic_object_number_for_molecule() : c-interface-generic-objects.h. ... new_molecule_by_symmetry_with_atom_selection() : c-interface.h. -
Packaging molecular motors for delivery - MRC Laboratory of Molecular …
https://www2.mrc-lmb.cam.ac.uk/packaging-molecular-motors-for-delivery/26 Feb 2021: The airways in our lungs are kept clear of mucus by the rhythmic beating motion of slender cellular extensions called cilia, driven by dynein motors. Andrew Carter’s group, has discovered a novel protein that packages these molecular motors for -
Coot Scripting Interface: get-monomer.hh File Reference
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/get-monomer_8hh.html24 Aug 2021: Returns. the new molecule number, if not -1 (error). Generated by . 1.8.5. -
Pathway behind disposal of ‘orphan’ proteins identified - MRC…
https://www2.mrc-lmb.cam.ac.uk/pathway-behind-disposal-of-orphan-proteins-identified/27 Aug 2021: This new insight, that an assembly factor can also recruit degradation factors such as HERC1, might apply to many other protein complexes in the cell that rely on their own specialised ... Therefore, identification of quality control factors such as -
Engaging online for the first Cambridge Festival - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/engaging-online-for-the-first-cambridge-festival/4 May 2021: LMB scientists contribute to the Cambridge Festival with a livestreamed lab tour and a set of activities showing how studying worms can help us understand our brains -
“The LMB provides an unsurpassed environment for both new ...
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/www2.mrc-lmb.cam.ac.uk/?wpdmdl=1885218 Jan 2021: cell type that controls the start of allergic asthma, providing a critical first step in developing new. ... to solve the structureof the ribosome and is. informing work to develop new antibiotics. -
TRIM21 is both enzyme and substrate when creating a signal to degrade …
https://www2.mrc-lmb.cam.ac.uk/trim21-is-both-enzyme-and-substrate-when-creating-a-signal-to-degrade-bound-viruses-and-proteins/2 Mar 2021: The intracellular immune receptor TRIM21 detects antibody-bound viruses inside our cells and targets them for destruction by creation of a polyubiquitin signal. David Neuhaus’ group, with Leo James’, has shown that TRIM21 is both the enzyme and -
Tail of SARS-CoV-2 Spike protein is optimised to reach the cell…
https://www2.mrc-lmb.cam.ac.uk/tail-of-sars-cov-2-spike-protein-is-optimised-to-reach-the-cell-surface-causing-infection-to-spread-to-neighbouring-cells/10 Sep 2021: Most of these new Spike proteins accumulate in an intracellular structure named Golgi which assembles new viruses. ... the Golgi apparatus, then hold it there whilst new viruses are made. -
Early transcriptional patterning of a forming tissue is essential to…
https://www2.mrc-lmb.cam.ac.uk/early-transcriptional-patterning-of-a-forming-tissue-is-essential-to-morphogenesis-of-a-tubular-organ/8 Nov 2021: Time-lapse quantitative study of developing salivary glands in Drosophila embryos, conducted by Katja Röper’s group, reveals the key control factors behind cells’ behavioural transitions that are essential for correct organ formation. -
Microscopy, 2021, 1–6doi:https://doi.org/10.1093/jmicro/dfab023…
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/mic21.pdf26 Jul 2021: Abstract. Many new structures of membrane proteins have been determined over the last decade, yet thenature of protein–lipid interplay has received scant attention. ... Plenum Press, New York). 18. Liu Y-T, Tao C-L, Zhang X, Xia W, Shi D-Q, Qi L, Xu C, -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x75.html24 Aug 2021: update_go_to_atom_window_on_new_mol() : c-interface.h. -
Alex Betz - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/alex-betz/30 Mar 2021: Alexander Betz Alex joined the PNAC Division in 1997 as a Programme Leader Track, before becoming a Programme Leader in 2008. He left the LMB in September -
How the fate of immune cell precursors is decided - MRC Laboratory of …
https://www2.mrc-lmb.cam.ac.uk/how-the-fate-of-immune-cell-precursors-is-decided/11 Jan 2021: 11 January, 2021. Discovery of a new checkpoint that controls the development of innate immune cells with a key role in parasite defence and allergy. ... This led to their proposal of a new transcription factor network to explain how RORα regulates -
Coot Scripting Interface: cc-interface.hh Source File
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/cc-interface_8hh_source.html24 Aug 2021: 474 // return the status and vector of chain-ids of the new chain ids. ... 1312 mmdb::Manager new_molecule_by_symmetry_matrix_from_molecule(mmdb::Manager mol,. -
Behind the scenes: Paul Hart and the development of IT at the LMB -…
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/share-your-memories/behind-the-scenes-paul-hart-and-the-development-of-it-at-the-lmb/20 Dec 2021: The biggest challenge. Several year later the new building project came my way. ... I’d worked on a couple of new building projects, but never as a lead. -
Dinolite Instructions
https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/downloads/dinolite_instructions_detailed_2021.22_LJM.doc18 Oct 2021: If no new image appears, move the mouse until it does (you may see the last image taken otherwise). ... 5. To take a new image, place your mouse over anything other than an existing thumbnail. -
The Coot User Manual
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/docs/coot.html1 Mar 2021: The Coot User Manual -
KENDREW LECTURE(Part 1) Demis HassabisFounder & CEO DeepMind,…
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/www2.mrc-lmb.cam.ac.uk/?wpdmdl=2135527 Sep 2021: Using AI to accelerate scientific discoveryWednesday 13th October @ 2.30 pmDetails on the LMB website https://www2.mrc-lmb.cam.ac.uk/news-and-events/scientific-seminars/. -
KENDREW LECTURE(Part 2) Wednesday 13th October @ 4.00 pmDetails ...
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/www2.mrc-lmb.cam.ac.uk/?wpdmdl=2135627 Sep 2021: KENDREW LECTURE(Part 2). Wednesday 13th October @ 4.00 pmDetails on the LMB website https://www2.mrc-lmb.cam.ac.uk/news-and-events/scientific-seminars/. -
Setting the stage: development of sample holders for electron ...
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/www2.mrc-lmb.cam.ac.uk/?wpdmdl=2129521 Jun 2021: Also, parts can move during specimen translation, making a new contact with small temperature differences between the contacting parts. ... 1996 Bob Morrison of Gatan Inc., designed a holder for a new Phillips prototype to be used with liquid helium. -
Coot Scripting Interface: c-interface.h Source File
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/c-interface_8h_source.html24 Aug 2021: 447. 457 int add_ligand_delete_residue_copy_molecule(int imol_ligand_new,. ... If it doesn't then we /. 1527 / go down a (new 20060920) different path. /. -
Cryo‐EM structure of the full‐length Lon protease from Thermus…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Lon%20Coscia%202021%20FEBS.pdf14 Nov 2021: The new model containing a coiled-coil. a-helix describes map 2 well. ... Hagen WJH, Lindahl E and Scheres SHW (2018) New. tools for automated high-resolution cryo-EM structure. -
BIO CHEM ISTR Y Structure of the SARS-CoV-2 RNA-dependent ...
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/SARS%20polym%202021%20e2021946118.full.pdf29 Aug 2021: High-resolution structure deter-mination may aid in these directions as new compounds are developed andtested as treatments for COVID-19. ... 9, 2. 021. 20. J. Zivanov et al., New tools for automated high-resolution cryo-EM structuredetermination in -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x64.html24 Aug 2021: default_new_atoms_b_factor() : c-interface.h. -
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/COVID%20vaccine%202021%201873-3468.14171.pdf29 Aug 2021: Q5 High-Fidelity 2X Master Mix (New England Biolabs,. Ipswich, MA, USA) as per manufacturer’s instructions. -
LMB scientists honoured by Biochemical Society Awards - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-scientists-honoured-by-biochemical-society-awards/30 Mar 2021: This award is given every three years to recognise exemplary work leading to the development of a new method or reagent. ... Recently, Maria has used an integrative approach combining data on transcriptomics, genomics, proteomics, receptor sequence and -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_func_0x75.html24 Aug 2021: update_go_to_atom_window_on_new_mol() : c-interface.h. -
Max Perutz (1914 - 2002) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/max-perutz-1914-2002/30 Mar 2021: This move would lead to him becoming a pioneer in the new field of molecular biology, co-founding a world-class research laboratory and developing a technique to unlock the structures -
Francis Crick (1916 - 2004) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/francis-crick-1916-2004/30 Mar 2021: the centre of the new field of molecular biology.
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