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  2. A new way to mark bacterial invaders for destruction - MRC Laboratory …

    https://www2.mrc-lmb.cam.ac.uk/a-new-way-to-mark-bacterial-invaders-for-destruction/
    Thumbnail for A new way to mark bacterial invaders for destruction - MRC Laboratory of Molecular Biology 19 May 2021: Search this website. A new way to mark bacterial invaders for destruction. ... A new way to mark bacterial invaders for destruction. Published on.
  3. A new 2D protein material for studying receptor endocytosis - MRC…

    https://www2.mrc-lmb.cam.ac.uk/a-new-2d-protein-material-for-studying-receptor-endocytosis/
    Thumbnail for A new 2D protein material for studying receptor endocytosis - MRC Laboratory of Molecular Biology 6 Jan 2021: The fields of artificial biology and biomaterial engineering aim to take advantage of these functions and manipulate proteins so that they have new capabilities. ... This new material could therefore be of benefit to immunotherapy by blocking receptor
  4. Classification of human tauopathies based on tau filament folds - MRC …

    https://www2.mrc-lmb.cam.ac.uk/classification-of-human-tauopathies-based-on-tau-filament-folds/
    Thumbnail for Classification of human tauopathies based on tau filament folds - MRC Laboratory of Molecular Biology 29 Sep 2021: Moreover, this method provides new ways for studying the similarities and differences between diseases. ... This new classification complements the previous clinical diagnostic and neuropathological approaches, and allows for the identification of new
  5. LMB’s new exhibition room is officially open - MRC Laboratory of…

    https://www2.mrc-lmb.cam.ac.uk/lmbs-new-exhibition-room-is-officially-open/
    Thumbnail for LMB’s new exhibition room is officially open - MRC Laboratory of Molecular Biology 1 Jul 2021: Search this website. LMB’s new exhibition room is officially open. LMB’s new exhibition room is officially open. ... supporting the Max Perutz Lecture Theatre above, which needed to remain undisturbed and incorporated into the new design.
  6. Targeting RNA replication in SARS-CoV-2 - MRC Laboratory of Molecular …

    https://www2.mrc-lmb.cam.ac.uk/targeting-rna-replication-in-sars-cov-2/
    Thumbnail for Targeting RNA replication in SARS-CoV-2 - MRC Laboratory of Molecular Biology 3 Feb 2021: The polymerisation assays indicated that favipiravir-RTP is only weakly incorporated into a new RNA strand, but nonetheless suppresses RNA replication by acting as a competitive inhibitor of GTP. ... Either of these are important potential directions to
  7. Coot Scripting Interface: c-interface.h File Reference

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/c-interface_8h.html
    24 Aug 2021: void . set_molecule_name (int imol, const char new_name). set the molecule name of the imol-th molecule. ... Return -1 on failure to make an averaged map, otherwise return the new map molecule number.
  8. Scaling-up grid manufacture to solve bottleneck in cryo-EM - MRC…

    https://www2.mrc-lmb.cam.ac.uk/scaling-up-grid-manufacture-to-solve-bottleneck-in-cryo-em/
    Thumbnail for Scaling-up grid manufacture to solve bottleneck in cryo-EM - MRC Laboratory of Molecular Biology 3 Nov 2021: New grid has the potential to ease bottleneck on demand, keeping ‘fuel’ in microscopes. ... Now, due to this new large-scale method for making the grids, HexAuFoil grids will become accessible to everyone in the cryo-EM field.
  9. Understanding TRIM21 activation allows Trim-Away toolbox expansion -…

    https://www2.mrc-lmb.cam.ac.uk/understanding-trim21-activation-allows-trim-away-toolbox-expansion/
    Thumbnail for Understanding TRIM21 activation allows Trim-Away toolbox expansion - MRC Laboratory of Molecular Biology 9 Mar 2021: Leo’s group has now exploited new understanding of Trim-Away’s mechanism of activation to expand the technology’s toolbox.
  10. Linda Amos (1943 - 2021) - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/linda-amos-1943-2021/
    Thumbnail for Linda Amos (1943 - 2021) - MRC Laboratory of Molecular Biology 26 Feb 2021: Linda Amos, former Group Leader in the LMB’s Structural Studies Division, died on Sunday 21st February 2021. Linda was an excellent electron microscopist, at the forefront of image analysis and reconstruction.
  11. Ben Nichols - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/ben-nichols/
    Thumbnail for Ben Nichols - MRC Laboratory of Molecular Biology 30 Mar 2021: Ben Nichols Ben Nichols first joined the LMB’s Cell Biology Division in 1996, as a postdoctoral scientist in Hugh Pelham’s group, working on yeast
  12. New structures show how auxiliary subunits modulate hippocampal AMPA…

    https://www2.mrc-lmb.cam.ac.uk/new-structures-show-how-auxiliary-subunits-modulate-hippocampal-ampa-receptor-neurotransmission/
    Thumbnail for New structures show how auxiliary subunits modulate hippocampal AMPA receptor neurotransmission - MRC Laboratory of Molecular Biology 2 Jun 2021: Search this website. New structures show how auxiliary subunits modulate hippocampal AMPA receptor neurotransmission. ... New structures show how auxiliary subunits modulate hippocampal AMPA receptor neurotransmission.
  13. Biogrpahical

    https://www2.mrc-lmb.cam.ac.uk/groups/rh15/Biographical.html
    14 Apr 2021: LMB also continues to develop techniques and methods alongside tackling challenging new scientific problems.
  14. Briggs SARS-CoV-2 Image - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/download/briggs-nature-cover/
    Thumbnail for Briggs SARS-CoV-2 Image - MRC Laboratory of Molecular Biology 31 Mar 2021: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Downloads
  15. Testing the capacity for intracellular antibodies to neutralise…

    https://www2.mrc-lmb.cam.ac.uk/testing-the-capacity-for-intracellular-antibodies-to-neutralise-sars-cov-2/
    Thumbnail for Testing the capacity for intracellular antibodies to neutralise SARS-CoV-2 - MRC Laboratory of Molecular Biology 29 Jul 2021: Leo James’ group, in the LMB’s PNAC Division, has developed a new assay that can measure the anti-viral activity of anti-N antibodies in blood samples. ... how many new virions are produced or quantifying the amount of viral RNA present.
  16. “The LMB provides an unsurpassed environment for both new ...

    https://www2.mrc-lmb.cam.ac.uk/?wpdmdl=18852
    18 Jan 2021: cell type that controls the start of allergic asthma, providing a critical first step in developing new. ... to solve the structureof the ribosome and is. informing work to develop new antibiotics.
  17. Brian Hartley (1926 – 2021) - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/brian-hartley-1926-2021/
    Thumbnail for Brian Hartley (1926 – 2021) - MRC Laboratory of Molecular Biology 7 May 2021: rd. May 2021. Brian made outstanding contributions to protein chemistry, with his invention of new analytical methods, and produced for the first time an understanding of the properties of proteolytic enzymes ... Brian continued his work on the sequence
  18. Evolutionary journey of mycobacteria mapped - MRC Laboratory of…

    https://www2.mrc-lmb.cam.ac.uk/evolutionary-journey-of-mycobacteria-mapped/
    Thumbnail for Evolutionary journey of mycobacteria mapped - MRC Laboratory of Molecular Biology 30 Apr 2021: the new virulent clones of M. ... abscessus, and prevent the emergence of new ones. Without this, it is likely that increased opportunities for direct transmission of pathogenic mycobacteria – because of factors such as rising population density or
  19. Coot Scripting Interface: c-interface-generic-objects.h File Reference

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/c-interface-generic-objects_8h.html
    24 Aug 2021: new_generic_object_number (const std::string &obj_name). create a new generic object with name objname More.. ... int new_generic_object_number. (. const std::string &. obj_name. ). create a new generic object with name objname.
  20. Browse the photo archive - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/photographs/browse-all/
    Thumbnail for Browse the photo archive - MRC Laboratory of Molecular Biology 31 Mar 2021: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Browse
  21. Covid19 Image - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/download/covid19-image-download/
    Thumbnail for Covid19 Image - MRC Laboratory of Molecular Biology 30 Mar 2021: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Downloads
  22. Coot Scripting Interface: File Members

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x6e.html
    24 Aug 2021: new_generic_object_number_for_molecule() : c-interface-generic-objects.h. ... new_molecule_by_symmetry_with_atom_selection() : c-interface.h.
  23. Coot Scripting Interface: File Members

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_func_0x6e.html
    24 Aug 2021: new_generic_object_number_for_molecule() : c-interface-generic-objects.h. ... new_molecule_by_symmetry_with_atom_selection() : c-interface.h.
  24. Packaging molecular motors for delivery - MRC Laboratory of Molecular …

    https://www2.mrc-lmb.cam.ac.uk/packaging-molecular-motors-for-delivery/
    Thumbnail for Packaging molecular motors for delivery - MRC Laboratory of Molecular Biology 26 Feb 2021: The airways in our lungs are kept clear of mucus by the rhythmic beating motion of slender cellular extensions called cilia, driven by dynein motors. Andrew Carter’s group, has discovered a novel protein that packages these molecular motors for
  25. Coot Scripting Interface: get-monomer.hh File Reference

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/get-monomer_8hh.html
    24 Aug 2021: Returns. the new molecule number, if not -1 (error). Generated by . 1.8.5.
  26. Pathway behind disposal of ‘orphan’ proteins identified - MRC…

    https://www2.mrc-lmb.cam.ac.uk/pathway-behind-disposal-of-orphan-proteins-identified/
    Thumbnail for Pathway behind disposal of ‘orphan’ proteins identified - MRC Laboratory of Molecular Biology 27 Aug 2021: This new insight, that an assembly factor can also recruit degradation factors such as HERC1, might apply to many other protein complexes in the cell that rely on their own specialised ... Therefore, identification of quality control factors such as
  27. Engaging online for the first Cambridge Festival - MRC Laboratory of…

    https://www2.mrc-lmb.cam.ac.uk/engaging-online-for-the-first-cambridge-festival/
    Thumbnail for Engaging online for the first Cambridge Festival - MRC Laboratory of Molecular Biology 4 May 2021: LMB scientists contribute to the Cambridge Festival with a livestreamed lab tour and a set of activities showing how studying worms can help us understand our brains
  28. “The LMB provides an unsurpassed environment for both new ...

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/www2.mrc-lmb.cam.ac.uk/?wpdmdl=18852
    18 Jan 2021: cell type that controls the start of allergic asthma, providing a critical first step in developing new. ... to solve the structureof the ribosome and is. informing work to develop new antibiotics.
  29. TRIM21 is both enzyme and substrate when creating a signal to degrade …

    https://www2.mrc-lmb.cam.ac.uk/trim21-is-both-enzyme-and-substrate-when-creating-a-signal-to-degrade-bound-viruses-and-proteins/
    Thumbnail for TRIM21 is both enzyme and substrate when creating a signal to degrade bound viruses and proteins - MRC Laboratory of Molecular Biology 2 Mar 2021: The intracellular immune receptor TRIM21 detects antibody-bound viruses inside our cells and targets them for destruction by creation of a polyubiquitin signal. David Neuhaus’ group, with Leo James’, has shown that TRIM21 is both the enzyme and
  30. Tail of SARS-CoV-2 Spike protein is optimised to reach the cell…

    https://www2.mrc-lmb.cam.ac.uk/tail-of-sars-cov-2-spike-protein-is-optimised-to-reach-the-cell-surface-causing-infection-to-spread-to-neighbouring-cells/
    Thumbnail for Tail of SARS-CoV-2 Spike protein is optimised to reach the cell surface causing infection to spread to neighbouring cells - MRC Laboratory of Molecular Biology 10 Sep 2021: Most of these new Spike proteins accumulate in an intracellular structure named Golgi which assembles new viruses. ... the Golgi apparatus, then hold it there whilst new viruses are made.
  31. Early transcriptional patterning of a forming tissue is essential to…

    https://www2.mrc-lmb.cam.ac.uk/early-transcriptional-patterning-of-a-forming-tissue-is-essential-to-morphogenesis-of-a-tubular-organ/
    Thumbnail for Early transcriptional patterning of a forming tissue is essential to morphogenesis of a tubular organ - MRC Laboratory of Molecular Biology 8 Nov 2021: Time-lapse quantitative study of developing salivary glands in Drosophila embryos, conducted by Katja Röper’s group, reveals the key control factors behind cells’ behavioural transitions that are essential for correct organ formation.
  32. Microscopy, 2021, 1–6doi:https://doi.org/10.1093/jmicro/dfab023…

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/mic21.pdf
    26 Jul 2021: Abstract. Many new structures of membrane proteins have been determined over the last decade, yet thenature of protein–lipid interplay has received scant attention. ... Plenum Press, New York). 18. Liu Y-T, Tao C-L, Zhang X, Xia W, Shi D-Q, Qi L, Xu C,
  33. Coot Scripting Interface: File Members

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x75.html
    24 Aug 2021: update_go_to_atom_window_on_new_mol() : c-interface.h.
  34. Alex Betz - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/alex-betz/
    Thumbnail for Alex Betz - MRC Laboratory of Molecular Biology 30 Mar 2021: Alexander Betz Alex joined the PNAC Division in 1997 as a Programme Leader Track, before becoming a Programme Leader in 2008. He left the LMB in September
  35. How the fate of immune cell precursors is decided - MRC Laboratory of …

    https://www2.mrc-lmb.cam.ac.uk/how-the-fate-of-immune-cell-precursors-is-decided/
    Thumbnail for How the fate of immune cell precursors is decided - MRC Laboratory of Molecular Biology 11 Jan 2021: 11 January, 2021. Discovery of a new checkpoint that controls the development of innate immune cells with a key role in parasite defence and allergy. ... This led to their proposal of a new transcription factor network to explain how RORα regulates
  36. Coot Scripting Interface: cc-interface.hh Source File

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/cc-interface_8hh_source.html
    24 Aug 2021: 474 // return the status and vector of chain-ids of the new chain ids. ... 1312 mmdb::Manager new_molecule_by_symmetry_matrix_from_molecule(mmdb::Manager mol,.
  37. Behind the scenes: Paul Hart and the development of IT at the LMB -…

    https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/share-your-memories/behind-the-scenes-paul-hart-and-the-development-of-it-at-the-lmb/
    Thumbnail for Behind the scenes: Paul Hart and the development of IT at the LMB - MRC Laboratory of Molecular Biology 20 Dec 2021: The biggest challenge. Several year later the new building project came my way. ... I’d worked on a couple of new building projects, but never as a lead.
  38. Dinolite Instructions

    https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/downloads/dinolite_instructions_detailed_2021.22_LJM.doc
    18 Oct 2021: If no new image appears, move the mouse until it does (you may see the last image taken otherwise). ... 5. To take a new image, place your mouse over anything other than an existing thumbnail.
  39. The Coot User Manual

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/docs/coot.html
    1 Mar 2021: The Coot User Manual
  40. KENDREW LECTURE(Part 1) Demis HassabisFounder & CEO DeepMind,…

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/www2.mrc-lmb.cam.ac.uk/?wpdmdl=21355
    27 Sep 2021: Using AI to accelerate scientific discoveryWednesday 13th October @ 2.30 pmDetails on the LMB website https://www2.mrc-lmb.cam.ac.uk/news-and-events/scientific-seminars/.
  41. KENDREW LECTURE(Part 2) Wednesday 13th October @ 4.00 pmDetails ...

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/www2.mrc-lmb.cam.ac.uk/?wpdmdl=21356
    27 Sep 2021: KENDREW LECTURE(Part 2). Wednesday 13th October @ 4.00 pmDetails on the LMB website https://www2.mrc-lmb.cam.ac.uk/news-and-events/scientific-seminars/.
  42. Setting the stage: development of sample holders for electron ...

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/www2.mrc-lmb.cam.ac.uk/?wpdmdl=21295
    21 Jun 2021: Also, parts can move during specimen translation, making a new contact with small temperature differences between the contacting parts. ... 1996 Bob Morrison of Gatan Inc., designed a holder for a new Phillips prototype to be used with liquid helium.
  43. Coot Scripting Interface: c-interface.h Source File

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/c-interface_8h_source.html
    24 Aug 2021: 447. 457 int add_ligand_delete_residue_copy_molecule(int imol_ligand_new,. ... If it doesn't then we /. 1527 / go down a (new 20060920) different path. /.
  44. Cryo‐EM structure of the full‐length Lon protease from Thermus…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Lon%20Coscia%202021%20FEBS.pdf
    14 Nov 2021: The new model containing a coiled-coil. a-helix describes map 2 well. ... Hagen WJH, Lindahl E and Scheres SHW (2018) New. tools for automated high-resolution cryo-EM structure.
  45. BIO CHEM ISTR Y Structure of the SARS-CoV-2 RNA-dependent ...

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/SARS%20polym%202021%20e2021946118.full.pdf
    29 Aug 2021: High-resolution structure deter-mination may aid in these directions as new compounds are developed andtested as treatments for COVID-19. ... 9, 2. 021. 20. J. Zivanov et al., New tools for automated high-resolution cryo-EM structuredetermination in
  46. Coot Scripting Interface: File Members

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x64.html
    24 Aug 2021: default_new_atoms_b_factor() : c-interface.h.
  47. Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/COVID%20vaccine%202021%201873-3468.14171.pdf
    29 Aug 2021: Q5 High-Fidelity 2X Master Mix (New England Biolabs,. Ipswich, MA, USA) as per manufacturer’s instructions.
  48. LMB scientists honoured by Biochemical Society Awards - MRC…

    https://www2.mrc-lmb.cam.ac.uk/lmb-scientists-honoured-by-biochemical-society-awards/
    Thumbnail for LMB scientists honoured by Biochemical Society Awards - MRC Laboratory of Molecular Biology 30 Mar 2021: This award is given every three years to recognise exemplary work leading to the development of a new method or reagent. ... Recently, Maria has used an integrative approach combining data on transcriptomics, genomics, proteomics, receptor sequence and
  49. Coot Scripting Interface: File Members

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_func_0x75.html
    24 Aug 2021: update_go_to_atom_window_on_new_mol() : c-interface.h.
  50. Max Perutz (1914 - 2002) - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/max-perutz-1914-2002/
    Thumbnail for Max Perutz (1914 - 2002) - MRC Laboratory of Molecular Biology 30 Mar 2021: This move would lead to him becoming a pioneer in the new field of molecular biology, co-founding a world-class research laboratory and developing a technique to unlock the structures
  51. Francis Crick (1916 - 2004) - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/francis-crick-1916-2004/
    Thumbnail for Francis Crick (1916 - 2004) - MRC Laboratory of Molecular Biology 30 Mar 2021: the centre of the new field of molecular biology.

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