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9 Oct 2020: In addition to these improvements, the new grid will enable higher throughput of data collection. ... This is because the new hexagonal arrangement of holes on these grids increases the usable holes by a factor of 10 relative to standard cryo-EM grids.

19 Aug 2020: Patrick Chitwood and Manu Hegde, in the LMB’s Cell Biology Division, have discovered a new type of chaperone that helps membrane proteins assemble correctly.

4 Mar 2020: Published on. 4 March, 2020. A new repair mechanism for alcohol-derived DNA crosslinks. ... Nature (Epub ahead of print). Nature News and Views:Primary Sidebar. Search. Search this website.

20 Jul 2020: Search this website. A new directed evolution technique to unlock the potential of XNAs. ... Amongst the new RT enzymes are the first enzymes capable of actively proof-reading during XNA reverse transcription, improving accuracy.

17 Jul 2020: Numerous new coronavirus-linked research projects were started within weeks and large donations of personal protective equipment (PPE) were coordinated. ... day. This involved bringing in and training around 30 new volunteers per week, who could then

3 Jun 2020: News and Views:Primary Sidebar. Search. Search this website. 2024 MRC Laboratory of Molecular Biology,.

4 Sep 2020: Venki Ramakrishnan’s group, in the Structural Studies Division, has now solved the structure of the protein complex formed when mRNA is being scanned to find the start codon, providing new

21 Oct 2020: Nature doi:10.1038/s41586-020-2829-0. Nature News and Views: Cryo-electron microscopy reaches atomic resolution. ... Nature News article:Primary Sidebar. Search. Search this website. 2024 MRC Laboratory of Molecular Biology,.

11 Jun 2020: wschafer[at]mrc-lmb.cam.ac.uk. Denise Walker - Research Scientist. Nationality: British. A central theme of my previous postdoctoral research has been to combine protein biochemistry with functional and behavioural assays,. to elucidate the role of

16 Mar 2020: Paul was most interested in developing new methods and technologies to improve research and information gathering, particularly in genomics. ... Paul’s main area of research was in genomics, particularly the development of new technologies and

7 Feb 2020: These new structures, and the concomitant increased understanding of how PARPs create the ADP-ribosylation that initiates DNA repair processes, could potentially lead to improvements in PARP inhibitor efficacy and novel

16 Jul 2020: Ribosome collisions along an mRNA ‘road’ relay a message to stop new ribosomes from entering while a tow truck clears the wreckage. ... To maximise efficiency, new ribosomes start translating an mRNA before previous ones have finished.

5 Nov 2020: A new layer of complexity in GPCR signalling could explain differences in receptor function and drug response. ... Nature. Nature News & Views:Primary Sidebar. Search. Search this website. 2024 MRC Laboratory of Molecular Biology,.

13 Feb 2020: These new structures also reveal the presence of additional molecules in a cavity within the filament. ... patients. Understanding how and why tau assembles into different disease-specific structures will also be beneficial for the development of new

2 Dec 2020: Design of new, improved drugs with fewer side-effects requires a fuller understanding of their structures.

11 Mar 2020: Scientific collaboration to focus on search for new, improved detectors for low energy cryo-EM. ... detector was essential to fully realise the potential of the new microscope design.

17 Feb 2020: New study, led by Pablo Alcón and Shabih Shakeel in Lori Passmore’s group, in collaboration with KJ Patel in the PNAC Division, uncovers a unique molecular “clamp and pin” mechanism that activates the D2l complex, which then recruits enzymes

21 Aug 2020: To provide a comprehensive analysis of all possible STR permutations, Pierre, working with Guillaume Guilbaud also from Julian’s group, developed a new high-throughput assay that allows measurement of DNA

21 Feb 2020: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. LMB Band

27 Nov 2020: Mitochondrial ribosomes are different from those in the cytoplasm of human cells and little is known about their quality control. Venki Ramakrishnan’s group has discovered a novel pathway to rescue stalled mitoribosomes and determined structures

3 Sep 2020: From modest beginnings Sydney became an extraordinarily influential and accomplished molecular biologist. His critical knowledge of, and insights into,

4 Aug 2020: Lipid membranes surround our cells and form the boundaries around compartments within them. Roger Williams’ group has now shown how membrane characteristics can tune the activities of protein complexes with important roles in autophagy and

28 Sep 2020: The LMB Director, Jan Löwe, recently ran an internal video competition in which staff and students could submit ideas for new films about life and science at the LMB. ... Michel: “The most important benefit to emerge from this new work is the

8 Jul 2020: To identify new treatments, scientists need a better understanding of the role played by different parts of the immune system in this disease. ... An improved understanding of the immune system in the gut and how to rebalance the

27 Oct 2020: for the radiation-induced specimen movement that has plagued the field for decades, with the design and creation of a new all-gold grid design that completely eliminates movement. ... With the help of new hardware and software, he led work to achieve

18 Aug 2020: John Briggs’ group, in the LMB’s Structural Studies Division, has led two new studies of the spike (S) protein that protrudes from the virus surface.

14 Apr 2020: Throughout March, 28 MRC-funded scientists, including three from the LMB, took part in the Medical Research Zone of I’m a Scientist, Get Me Out of Here

28 Aug 2020: Kelly Nguyen, group leader in the LMB’s Structural Studies Division, has been chosen to receive a Suffrage Science award along with ten fellow women scientists and science communicators who work in the life sciences.

20 Feb 2020: John was born and raised in New York City. He obtained his B.A., M.S. ... and Ph.D. from New York University. He then worked as a postdoctoral fellow in Bruce Stillman’s laboratory at Cold Spring Harbor from 1984–1990, where he began working on

5 Nov 2020: The importance of our brain is reflected in the measures evolved to protect it, including the skull and meninges. However, its immune defence has been less well understood. Menna Clatworthy’s group has now identified immune cells derived from the

9 Sep 2020: To do this, Julia infected mammalian cells with influenza A virus, leading to production of new viruses. ... Influenza causes very large numbers of cases of severe disease and death every year and new flu strains can cause global pandemics.

12 Aug 2020: Do it at least once. Each time I took part I gained a new perspective on my work and a better understanding of why some school students are put off by

12 Jun 2020: To study the development and function of the human ChP, including how CSF is made, Madeline’s group developed a new organoid model of this tissue. ... reduce the number of new drugs that fail in phase 1 clinical trials.

21 Jan 2020: Elaine is currently the Rebecca C. Lancefield Professor of Mammalian Cell Biology and Development at the Rockefeller University, New York, USA. ... We use skin as a model to understand how the microenvironment impacts the stem cells and their behavior in

7 Jul 2020: Our daily cycle is controlled by a central clock known as the SCN, but it has been unclear how the network of cells that make up the SCN generate the properties that make it a strong clock. Michael Hastings’ group has identified a signalling axis

5 Feb 2020: Thyroglobulin, the protein precursor to the thyroid hormones T3 and T4, is the only molecule in the human body that is modified by iodine, and the modification directly leads to the formation of the thyroid hormones in the thyroid gland. But the

23 Mar 2020: Led by Freda Chapman at the LMB, our staff raised £695 for Marie Curie, a registered charitable organisation, which provides care and support to people with terminal illnesses and their families.

28 May 2020: New research from the groups of Michel Goedert and Sjors Scheres has revealed the first structures of α-synuclein filaments from human brain.

16 Oct 2020: They found that the virus is able to infect and produce new virus inside ChP epithelial cells, but neurons and glia were not susceptible to infection. ... With the excellent support of my supervisor, Madeline Lancaster, and the expertise of Leo James’s

22 Sep 2020: Julian Gough has been named the Cambridge Enterprise Academic Entrepreneur of the Year for his work with Mogrify.

12 Jun 2020: Search this website. Marta Shahbazi wins 2019 3Rs prize for applying new in vitro models to study early embryo development. ... Marta Shahbazi wins 2019 3Rs prize for applying new in vitro models to study early embryo development.

22 Apr 2020: Hearing and touch depend on the ability of sensory neurons to be activated by a force, such as pressure or vibration from sound, and then pass information on to the brain. William Schafer’s group has identified some of the key proteins that make

4 Dec 2020: This reveals a new mechanism of immune synergy between antibodies and T cells, which are often thought to work quite separately. ... Therefore, this work provides multiple new concepts that could be exploited in the development of treatments for and

20 Oct 2020: Compare this maps with the original. You should find that the new (smooth) map is easier to understand. ... use the Display Manager to delete the first (mrc) map. Change the contour Step for the new Maps:.

17 Jun 2020: Understanding minute structural differences in (G protein-coupled receptor) GPCR complexes could lead to the design of more efficacious drugs that have fewer side effects

24 Nov 2020: Rebecca Taylor’s group has identified a signalling molecule that connects detection of a stressful environment by the nervous system with molecular defence mechanisms in other tissues and leads to changes in feeding behaviour and reproduction.

23 Jul 2020: Producing maps of how neurons connect with each other (connectomes) allows scientists to build and test theories of brain function. Greg Jefferis’ group have presented the first full map of olfactory, thermosensory, and hygrosensory projection

28 Aug 2020: The brain contains an enormous number of connections, known as synapses. Their loss is associated with many disorders. Radu Aricescu’s group and collaborators in Japan and Germany have designed a molecule that restores synapses in animal disease

23 Oct 2020: I have also started working on a new project with Radu Aricescu and Jan Löwe to test new vaccine candidates. ... chip model to understand the immune response to Mycobacterium tuberculosis and develop new drug treatments.

23 Jan 2020: The neuronal gene Arc plays important roles in neural plasticity, learning and memory-related molecular processes and has been shown to mediate intercellular RNA transfer by forming viral-like capsids. John Briggs’ group has now solved the first