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14 Oct 2019:

15 Nov 2019: Search this website. New understanding of protein abundance control. New understanding of protein abundance control. ... The discovery of a factor that regulates tubulin might in the future lead to new therapeutics for these diseases.

14 Aug 2019: Search this website. The LMB welcomes Benjamin Falcon as a new Group Leader. ... The LMB welcomes Benjamin Falcon as a new Group Leader. Published on.

27 Nov 2019: Cyrus’ innovative approach in applying his understanding of protein structures to completely sequenced genomes of organisms provided new insights into cellular systems.

11 Oct 2019: A new housing for a detector from DECTRIS, AG of Switzerland was made in the LMB workshop led by Steve Scotcher.

30 Aug 2019: Search this website. New cell death pathway in tuberculosis indicates potential use of commonly used drugs. ... New cell death pathway in tuberculosis indicates potential use of commonly used drugs.

3 Oct 2019: This new structure shows how the unwrapped DNA provides the major interaction interface between CCAN and the Cenp-A nucleosome. ... This new structure provides a framework for understanding decades of biochemical and genetic studies on the centromere and

21 Mar 2019: Search this website. New tau structures may benefit diagnosis and treatment of head injury-associated neurodegeneration. ... New tau structures may benefit diagnosis and treatment of head injury-associated neurodegeneration.

2 Oct 2019: Kiyoshi Nagai, Group Leader at the LMB and joint head of the Division of Structural Studies from 2001 to 2010, died on September 27th 2019 after a short

5 Jun 2019: M. Madan Babu, a Group Leader in the LMB’s Structural Studies Division, has been awarded the EMBO Gold Medal for his “fundamental contributions to the

27 Sep 2019: Chronic kidney disease affects more than 500 million patients worldwide, but there are no specific treatments that prevent disease progression. A lack of tissue availability has limited research into human kidney function and animal research

11 Oct 2019: provide the basis for development of new targeted drugs against these proteins that could be used to fight cancer.

18 Nov 2019: Search this website. New insights into the architecture of organelle contact sites, and the sites’ roles in cellular lipid fluxes. ... New insights into the architecture of organelle contact sites, and the sites’ roles in cellular lipid fluxes.

5 Feb 2019: This technology can be used to label proteins, add post-translational modifications and control enzymatic activity or protein transport within living cells, which in turn is providing new insights into many ... A goal of Jason’s current research is to

25 Apr 2019: We are regularly reminded that a balanced diet is key to staying healthy and preventing disease. What is less well known is that the time at which we eat

28 Aug 2019: There are, at present, three human proteasome inhibitors in clinical use mainly for the treatment of multiple myeloma, while new compounds are being developed both for better anti-cancer treatment and ... Previous Insight on Research: Structural insight

31 Jul 2019: Germ cells (sperm and eggs) constitute the pipeline that passes on the genetic instructions to make a new organism. ... They also provide an explanation for why human patients with Fanconi anaemia (a rare genetic blood disorder that prevents bone marrow

11 Jul 2019: The title of the lecture is ‘Innovation by evolution: bringing new chemistry to life’. ... Not satisfied with nature’s vast catalyst repertoire, we want to create new protein catalysts and expand the space of genetically encoded enzyme functions.

28 Mar 2019: On the first Saturday of the Festival, LMB scientists gave visitors to the “Hands-on at the Guildhall” event the opportunity to design and create a new model protein using modelling ... about how synthetic biology is changing our lives with the

31 Oct 2019: This led to the first purification of the intact natural complex, providing new insight into how it works. ... This new model will provide a basis for future investigations into the mechanisms of crosslink detection and recruitment of repair enzymes.

15 Aug 2019: and construct specialist scientific equipment and how the expertise of staff in the workshop has been of huge importance in developing new techniques.

26 Sep 2019: Brenda received her PhD from MIT before doing postdoctoral work at MGH Cancer Center, Boston and at Memorial Sloan-Kettering Cancer Center, New York.

16 May 2019: of a wide range of new molecules that could have benefits to medicine and biotechnology. ... Interestingly, this codon reassignment also has the consequence that this new synthetic E.

9 Apr 2019: Staff at the LMB have raised £226.77 for Marie Curie as part of “The Great Daffodil Appeal”. Freda Chapman, from the LMB’s Domestic Services team, led the

28 Oct 2019: I had to learn a huge number of new techniques during my PhD, and I did that with the help of people all across the LMB.

8 Aug 2019: wait}. On reading the new mtz file:. – In Amplitudes: choose FoutBlur_20.0. – ... Map {Select the FoutBlur_200.0} OK. Change the contour Step for the new Maps:.

26 Feb 2019: I will focus in particular on VPS13A and VPS13C, a new class of lipid transport proteins whose mutations result in neuroacanthocytosis (a Huntington’s disease-like condition) and Parkinson’s disease

10 Jul 2019: An improved understanding of how KAP1 functions in healthy individuals could suggest new strategies for treatment of these diseases.

18 Jul 2019: The LMB is delighted to announce that Michel Goedert from the Neurobiology Division has been awarded the Royal Society’s 2019 Royal Medal for Biological

4 Feb 2019: many new proteins in the next layer of this complex control system.

10 Dec 2019: The LMB recently hosted an exhibition of artworks produced as part of the PDB Art project. Now in its fourth year, this project involves the Protein Data Bank in Europe working with local school art departments to help students create works of art

23 Oct 2019: new exhibit developed by members of Lori Passmore’s group from the LMB’s Structural Studies Division.

17 Jun 2019: Illustration of some key findings from these two new studies: ‘instinctual’ neurons of the fly’s amygdala-analog, the lateral horn (middle panel), are better at telling apart different types of

21 May 2019: Our genetic code is translated from DNA into proteins through an intermediate molecule: messenger RNA (mRNA). One major way in which synthesis of proteins

21 Mar 2019: for diagnosis and potential development of new therapies. ... New tau structures may benefit diagnosis and treatment of head injury-associated neurodegeneration.

11 Jan 2019: disruption is associated with disease, which could open the way for new therapeutic interventions.

13 Feb 2019: Mariann Bienz’s group from the LMB’s PNAC Division, in collaboration with Doug Winton at the Cancer Research UK Cambridge Institute, have identified a potential new colorectal cancer therapeutic target ... Indeed, β-catenin is thought to be

23 Apr 2019: These new polymers may lead to novel applications in biotechnology and medicine and have implications for the chemical requirements for life on Earth and on other planets. ... therapeutics. The development of methods for producing and evolving these phNA

7 Feb 2019: Cryo-EM analysis showed the new conformation the engineered dynein adopts, helping to explain why dynein normally walks towards the minus-end of the microtubule.

10 May 2019: Thus, it is likely that this new understanding of the mechanism of altered binding after G protein activation will be relevant to many other drug targets.

6 Feb 2019: Apoptosis is a highly controlled form of cell death important for cell turnover during life, in embryonic development, including separation of fingers and

27 Jun 2019: LMB researchers took part in Bottisham Primary School’s Super Science Day, bringing the Synthetic Biology: Create a New Protein! ... Children then got the chance to make a new model protein using modelling clay, concepts from synthetic biology, and

28 May 2019: A Coot for Cryo-EM: 0.9 (pre-release). 1500 revisions ahead of the master branch This new branch is actively developed Considerations for the CootVR interface. ... Ignore it. – new Coot on Mac OS X and Windows doesn't matter.

8 Mar 2019: Indeed, a new study from Richard Youle’s group at the National Institutes of Health in the US, to which Felix’s group also contributed, and featuring in the same issue ... Felix’s group’s new finding that NDP52 acts at the upstream position of

22 Oct 2019: Launched in November 2018, the Rainwater Prize Program encourages and rewards scientific progress toward new treatments for neurodegenerative diseases related to the accumulation of tau protein in the brain. ... The Rainwater Prize Program fast-tracks

15 Mar 2019: A detailed knowledge of the structure of the binding site could enable design of other new anti-epilepsy drugs that block AMPA function.

18 Mar 2019: Although this new approach allows better maturation of mini-brains, they are still very small and lack the full repertoire and organisation of brain regions that are required for higher cognition.

1 Apr 2019: In this new study, 2-thiouridine was also found to be a key intermediate in the synthesis of the building blocks required for DNA.

1 Feb 2019: Although humans have a similar number of genes as flies, part of our greater complexity comes from a process called alternative splicing, in which

19 Jun 2019: Christopher Russo’s group in the LMB’s Structural Studies Division have now developed a new cryo-EM support involving modified graphene which improves image quality, allows high resolution structure determination,