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7 Jul 2017: Search this website. A new tool to study neural networks. A new tool to study neural networks. ... Progress in science often depends on new techniques and with this novel approach it is now finally possible to genetically manipulate neural networks and

15 Dec 2017: Search this website. New machinery for membrane protein insertion. New machinery for membrane protein insertion. ... a new membrane insertion machine called the ER Membrane protein Complex (EMC).

13 Dec 2017: New body clock display at the Science Museum. Published on. 13 December, 2017. ... Photo: Science Museum Group Collection. John O’Neill, group leader in the LMB’s Cell Biology Division, has helped develop a new display about body clocks for the

17 Nov 2017: Trim-Away: powerful new tool for studying protein function. Published on. 17 November, 2017. ... The scientists demonstrated the success of this new technique in removing a variety of proteins from a range of cell types.

12 Jan 2017: Search this website. New insights into the structure and dynamics of the catalytic spliceosome. ... New insights into the structure and dynamics of the catalytic spliceosome.

8 Feb 2017: Search this website. New insights into how peptides became a part of the ancient RNA world. ... New insights into how peptides became a part of the ancient RNA world.

31 Oct 2017: Search this website. New insights into ubiquitin phosphorylation and the development of early-onset Parkinson’s disease. ... New insights into ubiquitin phosphorylation and the development of early-onset Parkinson’s disease.

21 Dec 2017: In addition, a new website is being developed to share the activity resources so they can be used in public engagement by scientists around the world. ... a new ‘challenge project’ for 20 year 11 pupils in early 2018 based around DNA, taste and

4 Aug 2017: New research from Manu Hegde’s group in the LMB’s Cell Biology Division has led to the discovery of a factor that is responsible for finding orphan proteins and tagging

28 Jul 2017: Not the best shot, sorry about that (new camera required.).

27 Oct 2017: Now, work by Lori Passmore’s group in the LMB’s Structural Studies Division, in collaboration with Carol Robinson’s lab at the University of Oxford, has revealed new insights into ... They also reveal new insight (building on previous crystal

20 Jan 2017: SGTA proved to be the fastest at capturing new substrates and keeps them uncommitted from any fate. ... This work provides a molecular explanation and introduces new concepts for how protein triage decisions are made.

3 Feb 2017: Unlike these mammalian mitoribosomes the yeast mitoribosome has many new sections of rRNA and many of the proteins differ too. ... The task is now to identify why these differences arose and what role the new proteins are playing in the yeast mitoribosome

17 Nov 2017: Thus the mechanism revealed by this new research – whereby the end of the intron is recognised by the intron itself – was totally unexpected. ... Previous Insight on Research: New insights into the structure and dynamics of the catalytic spliceosome.

7 Dec 2017: By this time, Aaron had accepted an invitation for the group to join MRC funded scientists Max Perutz and John Kendrew at a new lab being planned in Cambridge.

11 May 2017: Thus, while the G proteins have been conserved throughout evolution, new organism-specific GPCRs have dynamically evolved to couple to an existing G protein and trigger specific signalling pathways.

9 Nov 2017: A new study has shown for the first time that these clocks also have a role to play in the healing of wounds, by ensuring that skin cells move quickly to ... The new research, led by John O’Neill’s group in the LMB’s Cell Biology Division in

8 Jun 2017: Dynein is also known to be involved with many diseases, for example viral infections, and a better understanding of how dynein works might lead to new ideas for the treatment of ... The work was funded by the MRC and a Wellcome Trust New Investigator

31 Jul 2017: New work by Julian Sale’s group in the LMB’s PNAC Division, in collaboration with Shankar Balasubramanian’s group in the University of Cambridge Department of Chemistry, has shown that ... This work suggests a new approach for epigenetic therapy,

16 Mar 2017: In order to probe the composition of the enhancesome, Moore (Laurens M.) van Tienen, from Mariann’s group, applied a relatively new technique called BioID proximity labelling, in order to define ... It could open up new avenues for therapeutic

30 Mar 2017: Brad’s talk ‘Life through a Lens’ showed spectacular new 3D images, made possible due to his development of the Mesolens.

20 Apr 2017: This move would lead to him becoming a pioneer in the new field of molecular biology, co-founding a world-class research laboratory and developing a technique to unlock the structures

31 Jul 2017: When given to mice, Sephin1 prevents two protein misfolding diseases. New work by the group has now uncovered the mechanism underlying this inhibition, opening up the possibility to target other holophosphatases ... Finally, swapping the N- and

9 Aug 2017: The LMB recently hosted eighteen students from the London International Youth Science Forum (LIYSF) for a morning of activities, talks and tours. The

28 Jun 2017: We were so pleased to be able to share our research into asthma and parasites, and explain to people how our exploration of the immune system can help to develop new ... their structure solved, and found out how this new technique is revolutionising

30 Oct 2017: New work by Sean’s group has now revealed the missing link that connects endosome-to-Golgi transport vesicles to the golgin tethers.

21 Aug 2017: In 1984 Jack moved his lab to the Department of Molecular Biology at the Massachusetts General Hospital where his work began to take on a new direction – the study of ribozymes. ... Mechanistic and structural studies have led to new chemical

30 Jan 2017: Professor Thomas Südhof will give the 2017 Milstein Lecture on Thursday 9th February 2017 at 4pm in the LMB’s Max Perutz Lecture Theatre. The lecture,

4 Oct 2017: The new structures provide important insights into the biological function of the assemblies and, by catalysing the subsequent development of new diagnostic or therapeutic tools, should help to improve the health

19 Jan 2017: The state of the immune system has effects on brain function, but despite suggestions that immunoregulators can affect people’s mood and behaviour, we are

6 Jul 2017: The development of new software by Shaoda He and Sjors was crucial for calculating the structures of the filaments to sufficient detail to deduce the arrangement of the atoms inside them. ... This opens up new possibilities to study a range of other

11 May 2017: LMB News:Primary Sidebar. Search. Search this website. 2024 MRC Laboratory of Molecular Biology,.

15 Aug 2017: New work spearheaded by Sreenivas Chavali in Madan Babu’s group in the LMB’s Structural Studies Division has shown that homorepeat-containing proteins (HRPs) are not always bad, and can ... It opens new horizons for answering questions about how

13 Mar 2017: Research lead by Marco Brancaccio, in Michael Hastings’s group in the LMB’s Neurobiology Division, has recently cast an entirely new light on the properties and activities of the astrocytes ... This study may provide new opportunities to control the

17 Aug 2017: This new research has several implications. Formaldehyde, which is apparently ubiquitous in our environment and lifestyles, is a well-known toxin to humans. ... bypass such approaches by using the new formaldehyde cycle discovered in this work.

13 Mar 2017: However, using a new chromosome conformation capture technique, Tim Stevens from the LMB’s Cell Biology Division, in collaboration with Ernest Laue’s group in the University of Cambridge Department of

19 Oct 2017: This work provides new and powerful theoretical tools to allow us to interpret these brain maps and understand the how the nervous system works at the most fundamental, cellular level.

30 Sep 2017: i.e., use the same description and apply it to the new ligand in question, just like for sugar links. ... generated by Acedrg's new mode). We don't have anything new to offer for modifications.

23 Mar 2017: The first weekend of the 2017 Cambridge Science Festival saw over 3000 visitors attend the 'Hands-on at the Guildhall' event, where the LMB’s 'See Your

19 Dec 2017: So if you click on (sele) you can toggle and untoggle your new selection. ... So if you want to make a new selection, make sure you deselect everything first!

4 Oct 2017: calculate new 2D average as probability weighted averages. Reference-free 2D class averaging. ... The bad news • The experimental data alone is not enough to determine a unique solu7on! •

29 May 2017: Added into a new N-linked tree: – paucimannose. 23/40. Xyl-β1,2. Xyl - β1,2 – Man – using XYP (beta D xylosepyranose). – ... both GUI interface and built into the auto-builder. New Interface.

6 Apr 2017: 3), requiring RsaA to adoptslightly different conformations. Furthermore, gaps in the latticewill be needed for insertion of new RsaA molecules on growingcells. ... The new culture was grown at 30 C for2–3 days. The culture was imaged using a

6 Oct 2017: Missing information due to discrete sampling. Data collection. Set new tilt angle. ... aligned toreference subtomograms. (aligned). averaged subtomograms(new reference). use new reference for alignmentiterate until reference is stable.

24 Oct 2017: The centre of the screen is a bit crowded now. Undisplay those new ligands. ... When we are happy with our fit, we can merge this new ligand into the mainprotein ligand as we did before.

29 Dec 2017: dejongeii DSM 12251 (PdBtubAB), a stop codon (TAA)was introduced before the C-terminal hexahistidine tag in the BtubAB bacterialT7 expression plasmid used (7) by Q5 mutagenesis (New England Biolabs). ... E5954 |

29 Sep 2017: new_atom_id _chem_mod_atom.new_type_symbol _chem_mod_atom.new_type_energy _chem_mod_atom.new_charge TMPmod1 delete H2. ... chem_mod_bond.new_type _chem_mod_bond.new_value_dist _chem_mod_bond.new_value_dist_esd TMPmod1 delete C1 H2 single.

4 Aug 2017: These constructs are in a vector (provided with the PURE system kit from New England Biolabs) that contains a T7 promoter and transcriptional terminator. ... The resin was washed four times with 1 ml PSB2 and transferred to a new tube after the fourth

3 May 2017: the divisome around the division site (17, 18).These findings have resurrected an old model of bacterial cell division: the templatemodel, in which the closing septum constricts by new cell wall ... because the energetic cost of losing subunits from ends

13 Jan 2017: using the Gibson Assembly kit (New England Biolabs).