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20 Jul 2016: 20 July, 2016. Researchers in Greg Jefferis’s group in the LMB’s Neurobiology Division have developed a new online tool to analyse images of neurons. ... NBLAST is already proving useful in fly brain research to identify neuron types, organize large

14 Dec 2016: New hypothesis for the formation of macropinocytic cups. Published on. 14 December, 2016. ... the USA and Robert Insall at the Beatson Institute in Glasgow, has resulted in the formation of a new hypothesis for how these cups form.

2 Sep 2016: Thus parental H3/4 tetramers are interspersed with newly synthesised H3/4. Most of the time, the old and new proteins are not mixed within the same nucleosome. ... In DT40 cells lacking Rev1, certain normally repressed genes containing G quadruplex DNA

13 Oct 2016: This has given unprecedented insight into the catalytic mechanism of a DUB and revealed a new mechanism of how ubiquitin chains can be cleaved. ... The new understanding of the catalytic process in deubiquitinases will become a key reference point for

24 Oct 2016: Search this website. New technologies enable systematic recoding of genomes. New technologies enable systematic recoding of genomes. ... Using these new techniques they attempted systematic recoding of the genomic sequence in an essential operon using

11 Feb 2016: Structural insight offers potential for new anti-malarial treatment. Published on. 11 February, 2016. . ... falciparum proteasome and used this information to design a new compound with promising anti-malarial properties.

1 Feb 2016: Search this website. Cryo-EM sheds new light on the spliceosome activation process. ... Cryo-EM sheds new light on the spliceosome activation process. Published on.

8 Dec 2016: Now researchers in the LMB’s Structural Studies and Cell Biology divisions have used electron cryomicroscopy (cryo-EM) to reveal new insights into these mechanisms. ... It is hoped that these new insights will enrich our understanding of the

26 Jul 2016: This has provided important mechanistic insights into RNA-based splicing catalysis. It has consolidated nearly three decades of biochemistry and genetics on the spliceosome and indicates new research directions to be

9 Mar 2016: She is also developing new methods with cryo-EM to help determine protein structure, including the development of new specimen grids made of pure gold, that improve the quality of

6 Jul 2016: The LMB’s Danielle Mersch and Nicola Smyllie along with other leading female scientists from the region took to their soapboxes on Saturday 2nd July in

4 Jan 2016: The new structure provides the first high resolution view of an open and functioning protein conducting channel. ... By comparing the new Sec61 structure to these previous structures, they have predicted a two-step mechanism for how the channel might be

1 Dec 2016: The LMB has continued its collaboration with the University Technical College Cambridge (UTCC), with students visiting as part of their microscopy

6 Sep 2016: Published on. 6 September, 2016. The ability of scientists to create changes in gene sequences has improved dramatically in recent years with the emergence of a new method, dubbed ‘CRISPR’. ... This new approach was inspired by work in rice, which

18 Mar 2016: 'Synthetic biology' is a scientific approach that seeks to answer fundamental questions in biology by reconstruction and modification of the molecules and

11 Mar 2016: In addition, AMPA receptors are drug targets and the new structure offers development to novel protein interfaces of the receptor.

7 Nov 2016: It gave me a new perspective to our work in the lab and I’m looking forward to next time!”.

23 Nov 2016: group working on new tissue culture methods.

15 Apr 2016: Target of Rapamycin (TOR) is a protein kinase that is essential in maintaining cellular homeostasis. In mammalian cells the enzyme occurs as two large

23 Mar 2016: As part of the Cambridge Science Festival, two of the LMB’s group leaders talked to the public about their research at the University Technical College

26 May 2016: This move would lead to him becoming a pioneer in the new field of molecular biology, co-founding a world-class research laboratory and developing a technique to unlock the structures

23 Jun 2016: Research by Manu Hegde’s lab in the LMB’s Cell Biology Division has found a new protein quality control pathway. ... More generally, a mechanistic understanding of the cell’s protein quality control pathways might eventually lead to new therapeutic

11 Aug 2016: 11 August, 2016. During eukaryotic cell division (mitosis) the cell’s chromosomes are duplicated and then equally separated into two new daughter cells.

2 Sep 2016: Yoshinori obtained his Ph.D. from the University of Tokyo. He completed a postdoctoral fellowship at The Rockefeller University in New York working on E.

18 May 2016: Tony Hunter will give the delayed John Kendrew Lecture 2015 on Wednesday 25th May 2016 at 15.00 in the LMB’s Max Perutz Lecture Theatre. The title of the

17 Oct 2016: Bonnie’s work also reveals a potential for the development of new classes of broad-spectrum antibiotics.

28 Jul 2016: Cell survival depends on adaptive signalling pathways to ensure that the supply of vital components matches the fluctuating needs of the cell. The

30 Sep 2016: The discovery has led to a new mechanistic model of Wnt signal transduction, in which Wnt-induced clustering of Dishevelled in clathrin-coated pits triggers DEP domain swapping and consequently signalosome

11 Aug 2016: This discovery presents the opportunity to re-evaluate existing treatments for HIV to improve their efficacy as well as a new drug target. ... Understanding how RTIs transit the pores opens new possibilities for improving their delivery.

14 Apr 2016: These daily magnesium oscillations also affect the circadian rhythm of when ‘clock genes’ are turned on and off, and therefore seem to be a new component of the cell’s biological

25 May 2016: to new antigens.

1 Jul 2016: Circadian clocks are found across all higher species, controlling daily rhythms of behaviour and physiology. They are thought to “tick” by producing and

9 Feb 2016: Adrian Bird will give the 2016 Francis Crick Lecture on Tuesday 16th February 2016 at 11.30am in the Max Perutz Lecture Theatre at the LMB. The lecture,

29 Jun 2016: The LMB has continued its collaboration with the University Technical College Cambridge (UTCC), with a series of visits, talks and a challenge project to

29 Feb 2016: The paper also describes how the cerebral organoids can be used to model human microcephaly, a disorder recently in the news because of its association with the Zika virus outbreak. ... The development of the ‘cerebral organoids’ has significant

19 Aug 2016: Cancer is an incredibly complex disease and data-intensive bioinformatics approaches can help interpret the molecular mechanism for why certain mutations cause disease, and possibly uncover the first steps of new

12 Aug 2016: The cause of a potentially fatal inherited autoimmune disease has been identified for the first time. The disease, now named OTULIN-related

15 Jul 2016: Features of The LMB Crystallization Screen: • A brand new set of the most successful.

2 Feb 2016: Cell-to-cell variability in gene expression level (noise) has emerged as one of the fundamental concepts in genetics. Non-genetic, cell-to-cell variation

26 Sep 2016: Do we even need something new? • Jligand. • Already part of CCP4 • Not really developed • 3D not 2D • Java. •

27 Apr 2016: We will make use of the new NCS tools in the latest version of refmac5. ... The two new fields that appear can be left at their default values.

29 May 2016: For each case, you should create a new project in CCP4i2.

4 Apr 2016: need help? please let us known). News. new features, release notes, and bug fixing reports).

9 Dec 2016: Dictionary entries. New coordinates (C2), based on above dictionary and REFMAC potentials.

14 Feb 2016: The new designs incorporate a number of improvements over other plates that we identified while using our high-throughput facility as described here.

9 Dec 2016: Re-refine. In the updated, Acedrg dictionary, the atom names are the same, one bond is different– Read old model and use new dictionary. – ... I'd rather work in coot and submit refinement jobs, and import and export new models and ligands. –

27 Apr 2016: We will make use of the new NCS tools in the latest version of refmac5. ... The two new fields that appear can be left at their default values.

28 Sep 2016: Lidia Improved letter placement. Old Coot New Coot RDKit. Coot Updates 0.8.7: Lidia. ... Given a ligand SMILES, how do I find out to which ligand (about which the PDB already knows) it is most similar?– Change the atom names of my new ligand to

30 Sep 2016: New Biol 3, 799–811 (1991). 7. Carnoy, C. & Roten, C. ... J. & Donachie, W. D. A new Escherichia coli cell division gene, ftsK.

4 Jan 2016: A simple filament nomenclature. Since ever more filament systems with new architectures are being. ... CM (2014) Subpolar addition of new cell wall is directed by DivIVA in.