Search

30 Jul 2015: Search this website. New body clock regulatory pathway discovered. New body clock regulatory pathway discovered. ... This reveals a whole new level of clock cell organisation and a new genetic pathway for controlling the body clock.

19 Mar 2015: Search this website. hiCLIP : New method finds structures of mRNA molecules. ... Jernej Ule and his group, while working in the LMB’s Structural Studies Division, developed a groundbreaking new method for studying the secondary structure of mRNAs and

22 Apr 2015: Search this website. New strategy for treating tuberculosis – inhibition of the DNA replication proofreader. ... It is therefore hugely important to develop new antibiotics and to understand DNA replication fidelity to deduce how drug resistance occurs.

7 Jul 2015: G protein coupled receptor (GPCR) mediated signalling is one of the largest and the most diverse signalling pathways in cellular systems. Human GPCRs

6 Aug 2015: Published on. 6 August, 2015. New research from the LMB’s Cell Biology and Structural Studies Divisions has answered a long-standing problem in molecular biology: how does the ribosome decode ... It is hoped that these new insights will not only enrich

9 Jan 2015: She discovered that two things happen before Listerin acts: the ribosome is split into its two subunits, and a new factor (called NEMF) binds the large subunit that contains the partially ... Concepts from this new work may help understand other quality

1 May 2015: His research has led to new insights into how toxins released from metabolism can damage the DNA of stem cells, particularly in those that produce blood. ... Each year, the Royal Society elects up to 52 new Fellows and up to ten new Foreign Members,

10 Apr 2015: Using cultured cells and mice as a model organism, Anne’s group have found a small molecule, named Sephin1

17 Jul 2015: This new research explains how phospho-ubiquitin activates Parkin and offers hope for new methods of Parkinson’s disease treatment.

1 Apr 2015: Many of our cells can engulf solid particles and liquid droplets to ingest (swallow) them. Phagocytes ingest invading bacteria and dead cells during

2 Mar 2015: Students from the new University Technical College (UTC) Cambridge have been taking part in a 6-week challenge project developed by the LMB. ... The UTC is a new regional centre for science education. It is an academy school open to 14-19 year old

17 Sep 2015: New research by John O’Neill, in the LMB’s Cell Biology Division, and Kenneth Wright, at the University of Colorado, has revealed the mechanism by which caffeine affects the human ... westward, as well as sustaining wakefulness until bedtime in the

18 Feb 2015: Dynactin is a protein complex that activates the dynein motor protein, enabling intracellular transport. It is extremely flexible and has proved very

16 Feb 2015: Worked on the structure and function of a new membrane interaction domain; the F-BAR domain. ... Became a PostDoc at Rockefeller, Field Research Center, New York, USA.

20 Apr 2015: The existence of an endogenous daily clock in humans is well known: it is what drives the 24-hour sleep/wake rhythm to match the daily cycle of night and

8 Dec 2015: Lewis is currently Director at the Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital, New York. ... He then went on to join the faculty of Weill Cornell Medical College and New York-Presbyterian Hospital in 2012.

15 Jun 2015: The atomic structure could help lead to new cancer treatments by providing a framework for the rational development of anti-cancer drugs.

17 Mar 2015: How did life first originate on this planet? Even the most minimal cell needs three subsystems: to convey information, to create compartments, and to

7 Jul 2015: Published on. 7 July, 2015. During fertilisation, an egg and a sperm fuse to form a new embryo. ... This is the first RNAi screen for meiotic genes in mammals and its development has allowed Melina’s group to analyse the function of nearly 800 genes,

2 Jun 2015: However, a new method developed by Jason Chin’s group in the LMB’s PNAC Division could revolutionise this research. ... Daniel also rewired the cell’s serine metabolism to incorporate a new version of phosphoserine that could not be hydrolysed

15 Dec 2015: Human eggs are frequently aneuploid, meaning they have the wrong number of chromosomes, and this is a major cause of pregnancy loss and Down syndrome.

5 Jun 2015: Miscarriages and genetic disorders, such as Down's syndrome, are often caused by errors when an egg develops from its progenitor cell, the oocyte. Most

25 Jun 2015: Genes in eukaryotic organisms are frequently interrupted by non-coding segments called introns. Before the protein can be produced, the entire length of each gene including the introns, is transcribed to produce precursor messenger RNA (pre-mRNA).

19 Oct 2015: Ribosomes, the molecular machines in cells that make proteins, are constructed in a series of discrete steps to create both a large and a small subunit.

27 Mar 2015: Children queued up excitedly during the Saturday and Sunday daytime sessions to use the microscopes, and the exhibit was also very popular in the new adults-only session on the Saturday

5 May 2015: There is compelling evidence that in the distant past, our single-celled ancestors used RNA, a chemical cousin of DNA, for both genetic information

25 Sep 2015: This new knowledge has implications for human health: children effected by the cancer and bone marrow failure syndrome Fanconi anaemia are unable to repair the DNA damage caused by formaldehyde.

27 Apr 2015: The structure of the actin-like protein ParM in different states has been revealed by Tanmay Bharat and Jan Löwe in collaboration with Garib Murshudov

19 May 2015: Jason Chin’s group from the LMB’s PNAC Division have created a new technique called BOLT that can selectively regulate specific proteins inside cells that could not previously be targeted. ... affected. Genetically engineering an entirely new site

21 Sep 2015: She then continued her work in the United States where she held Research Associate positions at the Rockefeller University, New York University Langone Medical Center and the Skirball Institute of Biomolecular

3 Jul 2015: This pioneering study shows that cryo-EM can be used for rational drug design, and could help the development of new therapeutic drugs for the treatment of conditions such as cancer,

9 Oct 2015: The structure of the Vps34 complex may facilitate new approaches to developing both inhibitors and activators of autophagy.

13 Feb 2015: Emeritus group leader Cyrus Chothia, from the LMB’s Structural Studies Division, has been honoured with two awards for his ground-breaking work in the use

17 Aug 2015: The atomic structure of the 170 kDa membrane protein gamma-secretase, a membrane protein complex that has an important role in Alzheimer’s disease, has

26 Nov 2015: DNA damage represents a constant threat to the integrity of genomic information in cells and is closely linked to the origins of cancer. 

8 Sep 2015: Coot displays a Map Colour Selection window]. • Choose a new colour by clicking on the colour widgets. ... Coot adds intermediate white atoms and pops up a dialog]. • Accept the new atoms.

26 Jun 2015: Discard the pipet tip, add a new pipet tip and pipet 1 ml of Crystal Screen Lite reagent 2 into reservoir A2.

11 Jul 2015: The body breaks proteins down into their individual building blocks, called "amino acids" and then uses the amino acids to build new proteins like dynein.

8 Sep 2015: Each new top score is highlighted () and the coordinates are updated to the final highest score.

20 Oct 2015: Engineering new synaptic connections in the C.elegans connectome. Ithai Rabinowitch & William R Schafer. ... 3B, right), presumablydue to negative charge flowing fromAWC into AIY through the new electricalsynapse (Fig.

27 Aug 2015: Coot displays a Map Colour Selection window]. • Choose a new colour by clicking on the colour widgets. ... We want a CYS:. • Mutate & Auto Fit. • Click on an atom in the new ALA.

16 Jul 2015: wwPDB Ligands. Year on year increase in the number of new entities. ... 6943 new ligand types (88%) are non-polymers. – LINKed ligands excluded.

14 Aug 2015: New imaging technology has made it possible to record neural activity from the majority ofC. ... 2. Lehner PN. Handbook of ethological methods. 2nd ed. Cambridge ; New York: Cambridge UniversityPress; 1996.

4 Feb 2015: New York, NY 10032, USA.}Present address: Department of Biochemistry. and Biophysics, University of California,. ... New York, NY 10010, USA. Electronic supplementary material is available. at http://dx.doi.org/10.1098/rsif.2014.0963 or.

30 Jun 2015: RESEARCH ARTICLE. Sensory Neurons Arouse C. elegansLocomotion via Both Glutamate andNeuropeptide ReleaseSeungwon Choi1,2,3, Kelsey P. Taylor1,2,3, Marios Chatzigeorgiou4, Zhitao Hu1,2,William R. Schafer4, Joshua M. Kaplan1,2,3. 1 Department of

27 Apr 2015: Clearly, new TubZ monomers incorporated only at thefilament ends that were free of TubRC (Fig. ... pH 7.5), 500 mM KCl, 10 mM EDTA, 0.5 mM TCEP] by chitin-affinity chromatography (New England Biolabs).

24 Sep 2015: treatment leads to improvement of ABCG2 mutant trafficking.We first determined whether the increased ABCG2 expressionon the cell surface required new protein synthesis. ... Here, we highlighted a new molecularmechanism, HDIs acting as modulators of

19 Aug 2015: The eRF1(AAQ) mutant was generated via Phusion mutagenesis.Antibodies against Hbs1 and ABCE1 have been described32; the eRF1 antibodywas from New England Biolabs.Release factor purification.

9 Sep 2015: Cotransin appears to trap the new protein chain within the Sec61 channel by essentially ‘locking’ the side-gate. ... By preventing the plug from moving out of the way, cotransin can somehow stop the new protein from passing through the side-gate.

24 Sep 2015: An ER Complex of ODR-4 and ODR-8/Ufm1 SpecificProtease 2 Promotes GPCR Maturation by a Ufm1-Independent MechanismChangchun Chen, Eisuke Itakura, Katherine P. Weber, Ramanujan S. Hegde, Mario de Bono. MRC Laboratory of Molecular Biology, Cambridge,