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Extracellular protein homeostasis in neurodegenerative diseases
www-vendruscolo.ch.cam.ac.uk/Wilson-2023-NRN.pdf28 Feb 2023: Overexpression of wild-type transthyre-tin in the APP23 mouse model of AD reduced cognitive and motor impairments, whereas silencing of the endogenous transthyretin gene promoted neuropathology76. ... Inspired by this mechanism, endogenous internal-izing -
The Vendruscolo Laboratory
www-vendruscolo.ch.cam.ac.uk/research.html28 Feb 2023: The endogenous proteins that are sequestered by the aggregates share distinct physicochemical properties: They are relatively large in size and significantly enriched in predicted unstructured regions, features that are strongly linked -
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress…
www-vendruscolo.ch.cam.ac.uk/aprile2017sr.pdf17 Sep 2017: Cas9 system21 for disruption of endogenous expression of the DNAJB6 gene in HEK293T cells. ... B) Immunocytochemistry showing expression of the endogenous DNAJB6a and DNAJB6b forms in α-syn-DsRed HEK293T cells. -
Protein regulation: The statistical theory of allostery
www-vendruscolo.ch.cam.ac.uk/vendruscolo11ncb.pdf15 Jan 2012: New research reveals that cell stress acts as a stimulus for double phosphorylation of endogenous Htt, causing its nuclear translocation, and shows that certain chemicals can target such molecular processes in -
Biochem. J. (2014) 462, 373–384 (Printed in Great Britain) ...
www-vendruscolo.ch.cam.ac.uk/blombach2014bj.pdf7 Oct 2014: Blombach and others. Figure 2 Expression of endogenous aMBF1 during different growth phases of S. ... C and D) Localization of endogenous aMBF1 in S. solfataricus P2 cell lysate. -
A tau homeostasis signature is linked with the cellular and regional…
www-vendruscolo.ch.cam.ac.uk/fu2019nn.pdf18 Dec 2018: 7a and Supplementary Fig. 11) induced accumulations of endogenous tau recognized by the 12E8 antibody, mainly in neurites (Fig. ... Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. -
Proteome-wide observation of the phenomenon of life on the edge of…
www-vendruscolo.ch.cam.ac.uk/Vecchi-2020-PNAS.pdf4 Feb 2020: 33. E. W. J. Wallace et al., Reversible, specific, active aggregates of endogenous proteinsassemble upon heat stress. ... Taylor, IbpA and IbpB, the new heat-shock proteins,bind to endogenous Escherichia coli proteins aggregated intracellularly by -
Widespread remodeling of proteome solubility in response to different …
www-vendruscolo.ch.cam.ac.uk/Sui-2020-PNAS.pdf4 Feb 2020: Tbc1d15 Epb4.1l3. Rbm42. Trim16. Fig. 2. Impact of a Httex1 mutation and subsequent aggregation on solubility of endogenous proteins. -
Identification and characterization of PKCg, a kinaseassociated with…
www-vendruscolo.ch.cam.ac.uk/takahashi2014hmg.pdf1 Mar 2015: 3E). These results suggestthe possibility that endogenous wild-type PKCg could formamyloid-like aggregates in vivo. ... These previous studies as well as the current onesuggest that some fractions of endogenous PKC isoformsmight form amyloid-like -
Science Journals — AAAS
www-vendruscolo.ch.cam.ac.uk/freer2016sa.pdf10 Aug 2016: Neugebauer, G. R. Jackson, R. Kayed, Alzheimer brain-derived tau oligomerspropagate pathology from endogenous tau.
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