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Robyn Macrae | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/robyn-macrae23 Feb 2024: Title: The apelin signalling system is composed of the G-protein coupled apelin receptor and its two endogenous peptide ligands, apelin and Elabela/Toddler (ELA). ... Structure and pharmacology of the apelin receptor with a recommendation that -
BHF Oxbridge CRM Introduction | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/research/oxbridgecrm23 Feb 2024: To harness the capacity of endogenous stem cell and progenitor cells for repair and regeneration. -
https://www.cardiovascular.cam.ac.uk/taxonomy/term/30/feed
https://www.cardiovascular.cam.ac.uk/taxonomy/term/30/feed23 Feb 2024: of metabolism in multiple species by endogenous enzymes.</a> Kirchmair J, Williamson MJ, Afzal AM, Tyzack JD, Choy AP, Howlett A, Rydberg P, <b>Glen RC</b>.<span class="jrnl" -
Poster Abstracts | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/poster-abstracts23 Feb 2024: Background: The apelin receptor, a class A GPCR, binds two endogenous peptide ligands, apelin and ELA, to induce potent vasodilatation and increase cardiac output. ... Considering these limitations, we are developing a novel method for stimulating -
Dr Janet Maguire | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/jmaguire23 Feb 2024: Pyr. 1. ]apelin-13. (1-12). is a biologically active ACE2 metabolite of the endogenous cardiovascular peptide [Pyr. ... Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration -
BHF Oxbridge CRM Pump-Priming Funding | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/research/oxbridgecrm/bhf-centre-of-regenerative-medicine-funding23 Feb 2024: Bristol. Development of novel zebrafish models to analyse endogenous extracellular vesicle trafficking during the cardiac injury response and subsequent regeneration.. -
Prof Anthony Davenport | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/adavenport23 Feb 2024: In first in human, proof of principle studies, MM07 was a more efficacious dilator in human forearm and hand vein via the G-protein mediated pathway than the endogenous peptides. ... and Maguire, J,J. (2017) [Pyr. 1. ]Apelin-13. (1-12). is a biologically -
Professor Guy Brown | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/gbrown23 Feb 2024: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. -
Dr Andrew Sage | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/asage23 Feb 2024: Recently, our lab defined the direct overall contribution of endogenous antibodies to atherosclerosis in a fully immunocompetent model. -
Dr Wei Li | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/wli23 Feb 2024: We also show that loss of endogenous BMP9 leads to lung vascular leak in vivo, and have developed BMP9 variants that maintain endothelial protective function but lack the bone-forming activity.
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