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{"id":22221,"date":"2022-01-20T12:51:11","date_gmt":"2022-01-20T12:51:11","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=22221"},"modified":"2022-01-20T12:51:11","modified_gmt":"2022-01-20T12:51:11","slug":"cryptochrome-proteins-are-integral-t

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HIV is a retrovirus, meaning it has to copy its RNA genome into DNA in order to infect cells.

This was because endogenous formaldehyde destroyed the blood stem cells residing in the bone marrow. ... In these patients reducing or counteracting endogenous formaldehyde production may be of therapeutic value.

n. The research team included collaborators from the MRC Centre for Medical Molecular Virology and the Retrovirus Research Laboratory, MRC University of Glasgow Centre for Virus Research.

{"id":14777,"date":"2019-07-10T09:30:53","date_gmt":"2019-07-10T08:30:53","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=14777"},"modified":"2019-07-10T09:30:53","modified_gmt":"2019-07-10T08:30:53","slug":"insights-into-how-kap1-silences-vira

We develop biochemical methods to obtain protein-nucleic acid complexes involved in telomere maintenance pathways both from endogenous sources and by overexpression methods.

Published on. 11 August, 2016. HIV is a retrovirus, meaning it has to copy its RNA genome into DNA in order to infect cells.

biological-timekeeping/","title":{"rendered":"Discovering the origins of biological timekeeping"},"content":{"rendered":". The existence of an endogenous daily clock in humans is well known: it is what drives the 24-hour

{"id":14452,"date":"2019-04-25T16:13:32","date_gmt":"2019-04-25T15:13:32","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=14591"},"modified":"2019-07-01T16:08:11","modified_gmt":"2019-07-01T15:08:11","slug":"how-eating-feeds-into-the-body-clock

This method is the first widely applicable protein degradation method that acts directly on the level of the endogenous protein.

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{"id":21691,"date":"2021-11-08T10:13:38","date_gmt":"2021-11-08T10:13:38","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=21691"},"modified":"2021-11-18T15:10:29","modified_gmt":"2021-11-18T15:10:29","slug":"early-transcriptional-patterning-of-

Published on. 20 April, 2015. The existence of an endogenous daily clock in humans is well known: it is what drives the 24-hour sleep/wake rhythm to match the daily

This “endogenous” formaldehyde is ubiquitous, and sufficient amounts might be produced that could damage our cells.

These are endogenous daily rhythms that […]. Uncharged DNA-like molecules can store genetic information and function like antibodies.

{"id":10846,"date":"2017-08-17T10:46:43","date_gmt":"2017-08-17T09:46:43","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/?p=10846"},"modified":"2021-07-19T13:48:36","modified_gmt":"2021-07-19T12:48:36","slug":"folate-and-formaldehyde-from-vitamin-

In the first step we created an orthogonal ribosome that is selectively directed to a new orthogonal message that is not read by endogenous ribosomes. ... We first selected, on 5FU, for sequences upstream of the cat-upp fusion that do not allow the gene

Note that despite endogenous amber codons we see minimal background labeling of non-target proteins, either on the cell surface or intracellularly.

Comparison of the kinetics of ERK2–GFP nuclear accumulation following MEK photoactivation or endogenous receptor stimulation provided some interesting insights.

We develop biochemical methodsnto obtain protein-nucleic acid complexes involved in telomere maintenancenpathways both from endogenous sources and by overexpression methods.

The pyrrolysyl-tRNA synthetase tRNAsubCUA/subu00a0pair is orthogonal with respect to the endogenous synthetases and tRNAs in emE.

In the first step we created an orthogonal ribosome that is selectively directed to a new orthogonal message that is not read by endogenous ribosomes. ... endogenous ribosome, creating a pool of potentially orthogonal ribosome binding sites.

the kinetics of elementary steps and adaptive feedback in kinase signalling./figcaption/figurenp /pnpComparison of the kinetics of ERK2u2013GFP nuclear accumulation following MEK photoactivation or endogenous receptor stimulation provided some

The pyrrolysyl-tRNA synthetase tRNA. CUA. pair is orthogonal with respect to the endogenous synthetases and tRNAs in E.

Note that despite endogenous amber codons we see minimal background labeling of non-target proteins, either on the cell surface or intracellularly./figcaption/figurenpWe have demonstrated the efficient site-specific incorporation

of DNA within the same strand or between opposite strands of the double-stranded helix, as a result of exposure to exogenous chemicals, such as chemotherapeutic drugs and alcohol, or endogenous

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{"id":17787,"date":"2020-04-09T09:36:35","date_gmt":"2020-04-09T08:36:42","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?page_id=17787"},"modified":"2024-04-23T16:38:13","modified_gmt":"2024-04-23T15:38:13","slug":"lmb-fellows","status":"publish

{"id":16108,"date":"2020-07-10T12:49:35","date_gmt":"2020-07-10T09:49:56","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?page_id=16108"},"modified":"2024-05-31T17:30:23","modified_gmt":"2024-05-31T16:30:23","slug":"blue-sky-collaboration","statu

mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/Leo-James-HIV-Nature-cover-28-July-16.jpg 700 700 HIV is a retrovirus, meaning it has to copy its RNA

existence of an endogenous daily clock in humans is well known: it is what drives the 24-hour sleep/wake rhythm to match the daily cycle of night and.