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Protein released from cells triggers chain reactions which may cause…
https://laser.ceb.cam.ac.uk/news/protein-released-from-cells-triggers-chain-reactions-which-may-cause-alzheimers-disease3 Jul 2024: Crucially these aggregates then trigger the endogenous, 'healthy' Tau that is naturally present in neurons to misbehave and co-aggregate with the ingested Tau. ... ingestion by adjacent, healthy neurons, could trigger nucleation and co-aggregation of -
Extracellular Monomeric Tau is Sufficient to Initiate the Spread of…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/extracellular-monomeric-tau-is-sufficient-to-initiate-the-spread-of-tau-pathology3 Jul 2024: K18 comprising the repeat domain, initially accumulate in endosomal compartments, where they form fibrillar seeds which subsequently induce the aggregation of endogenous Tau. ... Using superresolution imaging, we confirm that fibrils consisting of -
https://laser.ceb.cam.ac.uk/taxonomy/term/15/feed
https://laser.ceb.cam.ac.uk/taxonomy/term/15/feed3 Jul 2024: Laser Analytics Group - Invited Speakers https://laser.ceb.cam.ac.uk/directory/invited-speakers We have invited the following speakers to the Laser Analytics Group: Christopher Rowlands 15 May 2024 Dr Chris Rowlands started his academic career in -
Invited Speakers | Laser Analytics Group
https://laser.ceb.cam.ac.uk/directory/invited-speakers3 Jul 2024: Search site. Laser Analytics Group. Invited SpeakersWe have invited the following speakers to the Laser Analytics Group:. 15 May 2024. Dr Chris Rowlands started his academic career in 2001 at Imperial College, but on the other side of campus, in the -
Nanoscopic insights into seeding mechanisms and toxicity of…
https://laser.ceb.cam.ac.uk/system/files/documents/pnas-pintosi-2016.pdf3D), demonstrates that endogenous AS is pref-erentially recruited to elongate exogenous seeds rather thanundergoing nucleation. ... We find that these aggregates have a reducedpropensity to seed endogenous AS relative to preformed ASseed fibrils. -
Nanoscopic insights into seeding mechanisms and toxicity of…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/nanoscopic-insights-into-seeding-mechanisms-and-toxicity-of-a-synuclein-species-in-neurons3 Jul 2024: for elongation reactions which both consume endogenous α-synuclein and suppress its de novo aggregation. ... When α-synuclein is internalized in its monomeric form, however, it nucleates and triggers the aggregation of endogenous α-synuclein, leading -
Super-resolution imaging of alpha-synuclein polymorphisms and their…
https://laser.ceb.cam.ac.uk/system/files/documents/integrbiol-nugent-2017.pdfMore-over, our results showed that exogenously added monomerleads to the induction of endogenous a-synuclein aggregationwithout the two moieties coming into close proximity. ... incubated for 24 h in a-synuclein-free medium and immunostained for -
RNA Docking and Local Translation Regulate Site-Specific Axon…
https://laser.ceb.cam.ac.uk/publications/publication-summaries/rna-docking-and-local-translation-regulate-site-specific-axon-remodeling-in-vivo3 Jul 2024: Endogenous RNA tracking reveals that RNA granules dock at sites of branch emergence and invade stabilized branches. -
and Gabriele S. Kaminski SchierleEva-Maria Mandelkow, Clemens F.…
https://laser.ceb.cam.ac.uk/system/files/documents/jbc-michel-2013.pdfCrucially, the two-color assayrevealed the presence of both K18-647 and endogenous Tau in. ... The image displays K18-647 fibrils (red) thatare intertwined with endogenous Tau (green). -
Nanoscale imaging of neurotoxic proteins Clemens F. Kaminski,…
https://laser.ceb.cam.ac.uk/system/files/documents/spie-kaminski-2014.pdfIntriguingly, the cell expunges fibrillar aggregates that contain both the ingested K18Tau, shown in red, and endogenous wild type tau, already present in the cell, shown in green. ... F-1. Figure 5: Uptake of monomeric Tau protein into neuron-like cells
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