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18 Jun 2021: The project will inform the development, and test the feasibility of novel therapeutic strategies to treat heart failure. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

19 Aug 2021: This project aims to improve our understanding of the cellular mechanisms that underlie IR injury and test the safety and efficacy of promising novel therapeutic agents. ... This project will generate academic outputs, new treatment products, and the

13 Sep 2021: The project will inform the development, and test the feasibility of novel therapeutic strategies to treat heart failure. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

13 Sep 2021: This is why we need to use living animals to understand the complexity of the disease process and test the potential effect of new treatments. ... We will continue to test other non-animal strategies with the aim to replace the use of animals.

13 Sep 2021: We therefore wish to test if defects of the mouse EIF2AK4 gene can also be worsened by lung inflammation. ... be shown, and some account of the tests of significance to be made and the treatment differences that are to be estimated).

13 Sep 2021: Hence, medical conditions of the oesophagus represent an important social and economic burden, with a significant proportion of our public health budget spent in treatments that are inefficient and, in most ... 4. Test experiments, called pilot

20 Aug 2021: The lowest numbers of animals will be used consistent with obtaining a reasonable estimate of experimental variability to test for meaningful results between treatment groups. ... We will only test drugs in animals, when we know they work with isolated

19 Aug 2021: Data will be published from the in vivo biocompatibility tests in the licence. ... Some animals are used in pilot studies to test the compatibility of new potentially therapeutic compounds.

13 Sep 2021: Some animals in this project will be subjected to calorie restriction or exercise or behavioural tests, which are expected to cause no more than temporary stress until the animals have acclimatised. ... Whenever feasible and scientifically appropriate,

20 Aug 2021: We will then test these antibodies to see if they can be used as medicines. ... Aim 2 – Immunise these mice to make antibodies. Aim 3 – Test these antibodies in mouse models.

18 Jun 2021: Particular cells from animals can be used to test the effect of drugs that could stop a disease. ... Mice will be removed from test scenarios if suffering from an adverse stress reaction, or other unexpected adverse effects.

18 Jun 2021: This way we can test their safety before then testing them in a mouse. ... We can then use these cells to perform experiments that test our ideas about how human cells respond to treatments without having to use cells from mice beforehand.

13 Sep 2021: We can test many combinations of cells and materials in culture this way in order to optimise how we regenerate damaged hearts. ... This strategy of testing engineered heart tissues in culture will again reduce the number of animals finally used in the

19 Aug 2021: Then, we will test whether the findings which result from the frog embryo experiments can be reproduced in higher animals, we use rodents because their neurobiology is similar to humans’.

13 Sep 2021: The number of animals that will undergo surgery will depend on the number of factors that we plan to test over the course of the project, but we envisage to use

18 Jun 2021: short periods up to 4 hours of water restriction before behavioural tests.

18 Jun 2021: of blood cancers, will test the effect of and suggest the likely benefit of earlier therapy. ... Examples of cell-targeting substances include drugs that have been shown to effectively inhibit tumour cell growth when tested "in a test-tube".

19 Aug 2021: We test the function of each genetic alteration before breeding them together. ... I don’t anticipate many refinements to transgenic methods as these are already very standardised and efficient, though where these are reported we will test and

13 Sep 2021: short periods up to 4 hours of water restriction before behavioural tests.

19 Aug 2021: Isolated animals tend to gain more weight than controls; they are more responsive to stimuli predicting reward (in specific behavioural tests) and are hyperactive as measured by specific behavioural tasks. ... least 5 days a week (in average), but they

18 Jun 2021: We will follow these mice for several months and monitor them by clinical signs, imaging or blood tests. ... These mice will be monitored by clinical signs, periodic imaging or blood tests.

13 Sep 2021: malfunctioning causes diseases and test whether they can be used to cure or treat disease. ... We also plan to test the effectiveness of new therapies based around ubiquitin ligase biology in tumour transplantation models.

13 Sep 2021: In order to overcome these limitations and to provide a more ethical way to test smelling behaviour in mice, an automated testing apparatus called AutonoMouse has been recently developed.

19 Aug 2021: In the case of new chemicals, pilot experiments will be used to test chemical toxicity.

18 Jun 2021: We will use some cell culture models, for example to test the effects of specific lipid species on metabolic function.

19 Aug 2021: For the subcutaneous model in rats, small cylinders of the test material will be placed under the skin. ... from one of the test materials, and the bone will be stabilised with a metal orthopaedic plate and screws.

18 Jun 2021: test interventions at early stages that decrease the severity of the disease and help the development of treatments. ... The same behavioural and gut function tests and endpoints will be applied as described above.

19 Aug 2021: What's the aim of this project? To test anti-cancer agents in combination with ionising radiation with the aim of improving current clinical therapies. ... Animal studies are only performed after every feasible test has been conducted on cancer cells in

20 Aug 2021: The effects monitored in a similar way for example using a combination of the following: observation of general health and behaviour, regular blood tests, non-invasive imaging (e.g. ... Any models developed to test instruments or materials will take

20 Aug 2021: We used computer-based mathematical descriptions of brain activity to make specific predictions that require fewer animals to test. ... For this reason, the majority of our behavioural tests involve positive reward rather than punishment, in order to

18 Jun 2021: To test how effective vaccines are, pups will be infected with the viruses when adults. ... We will test all new medicines for treating virus infection in cells in the laboratory first, and only progress to animal experiments if positive results are

19 Aug 2021: This project will develop and test novel protective drugs for heart attack and stroke, as well as the resulting organ damage of chronic heart failure or chronic neurological disability, in order ... The main aim of the license is to test protective

18 Jun 2021: In the long-term (5-7 years), we expect that the findings of this study will result in the design of at least 1 human clinical trial to test the safety ... The purpose here will be to induce a disease, such as liver failure or diabetes, to test the

13 Sep 2021: To identify genes responsible for coloration differences we will test if it is possible to interbreed different species with different colour patterns using in vitro fertilisation methods. ... Gene modifications are confirmed by collecting tissue

19 Aug 2021: Over the same period, behavioural tests will be carried out once a week to test their ability to remain on a rotating cylinder and to cross a narrow beam. ... the expected number of studies to validate and test potential drugs for each project.

18 Jun 2021: 4. Test experiments, called pilot experiments, will be used to calculate the amount of a substance that we can safely inject into the animal. ... These test experiments will help us to work out how much this amount is but will only use a small number of

13 Sep 2021: mice, and; 4) in some cases, we will surgically transplant modified breast cells into the cleared breast tissue (Fatpad) of mice to test the effect of the certain genetic mutations on

13 Sep 2021: Because targets for these diseases are developing we are mostly focusing on helping the client with proof of concept studies, developing cell based assays to test their compounds in and then ... The techniques used for dosing with test agents and

18 Jun 2021: We will use this knowledge to develop and test new treatment strategies for pulmonary arterial hypertension and other related conditions. ... the length of the total process until we test the level of disease is 7 weeks.

20 Aug 2021: Pilot studies involve using a small number of mice to test the safety and efficacy of a method before using it on a larger number of mice.

18 Jun 2021: Then towards the end of the study we might perform a glucose tolerance test using an intraperitoneal (this means into the abdominal cavity) glucose injection. ... Before the glucose and insulin tolerance tests mice will be fasted for up to 6 hours.

19 Aug 2021: For example, phenotypes that we find in genetically altered embryos are confirmed by direct comparisons to control (un-altered) animals following the same test conditions. ... All of our experiments are designed to use only the number of animals needed

13 Sep 2021: Validate modes of action by modifying targets in transgenic parasites to specifically test these ideas. • ... Additionally, there is currently no alternative to animal species that can be used to test with regards to vaccine or drug sensitivity studies

20 Aug 2021: Fresh tissue is required by the client to run in vitro experiments to further the understanding of what causes disease and to test how drugs work. ... The client requires mice that have had their genes modified so that they can investigate what causes

13 Sep 2021: By doing so, we can test the activity of our new drug candidates on tumour growth in a more relevant way in a live animal. ... Our organization regularly uses a range of in vitro (taking place in a test tube or laboratory dish, outside a living animal)

13 Sep 2021: prevent unnecessary suffering, we also use non-interventional behavioural tests to measure the impact of arthritis/colitis on an animal’s behaviour.

13 Sep 2021: Our research will study how and where the bacteria hide in the body to resist to vaccines and antibiotics and will test new innovative vaccines.

13 Sep 2021: To get a better understanding of the models we will test known anti-cancer drugs to determine how well the tumours respond to therapies.

13 Sep 2021: Thus, mental health disorders place a considerable burden on not only the affected individual, but also social and economic burdens on society.

13 Sep 2021: This will create new opportunities to test new therapies that can stop bad inflammation. ... After the identification of targets, we will then proceed to test our results in our mouse models of disease.