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  1. Results that match 1 of 2 words

  2. Clay_thesis

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/AnthonyKempf.pdf
    4 Oct 2005: receptors. To test this possibility, we performed ablations that eliminated the egg-laying. ... laying interval times, a non-parametric test was used (the Mann-Whitney rank test).
  3. Identifying proteins bound to native mitotic ESC chromosomes reveals…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Djeghloul%20Nat%20Camms%202020.pdf
    11 Aug 2020: P-values of statistically significant increases, measured by unpaired two tailed Student’s t-tests, are indicated. ... P-values of statisticallysignificant decreases, measured by unpaired two tailed Student’s t-tests, are indicated.
  4. 318-320 News Feat Curves MH.indd

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/NatureAheadCurve.pdf
    17 Jul 2009: the artificially high concentrations present in the test tube. ... In the late 1990s, his graduate student Lars Dreier was mixing nuclear-envelope membranes with DNA, attempting to imitate in a test tube the way that the envelope reforms after cell
  5. doi:10.1016/j.molcel.2004.08.030

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Haering%20Mol%20Cell%202004.pdf
    20 Sep 2004: However, the disorder makes it difficult todesign specific mutants to test this hypothesis.its C terminus (Figure 1D). ... To test whether the S525N mutation Is There Any Turnover of Cohesin Subunits.
  6. 3747_0_supp_7_1052456676

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/christian.pdf
    9 May 2003: calcium concentration. To study the function of VGCCs we proceeded to test if. ... subunit UNC-36. Before proceeding to test VGCC mutants and subunit mutants we.
  7. 554 Research Paper Inhibition of receptor-mediated endocytosis by the …

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/wigge_McMahon1997.pdf
    21 Mar 2003: To test whether the cellulartarget of amphiphysin is dynamin, COS-7 cells were cotransfected with bothdynamin and the amphiphysin SH3 domain; here, transferrin uptake wasefficiently rescued. ... To test the hypothesis that the SH3 domain ofamphiphysin is
  8. Tutorial 6: Linear RegressionRob Nicholls –…

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/tutorials/linear_regression.pdf
    31 Mar 2014: This essentially tests whether the. Tutorial 6: Linear Regression 4. model has any predictive power. ... b) Create a model to test this hypothesis, assuming a linear relationshipbetween Height and Girth.
  9. The ER membrane protein complex promotes biogenesis of sterol-related …

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/JCS_2019.pdf
    18 Jan 2019: are shown (n=4). P0.01, P0.001 (Student’s t-test). 3. RESEARCH ARTICLE Journal of Cell Science (2019) 132, jcs223453. ... are shown (n=3).P0.001, P0.0001 (Student’s t-test). Reconstitution of Δ5 (D) and Δ6 cells (E) with empty vector control (EV),
  10. Tutorial 6: Linear RegressionRob Nicholls –…

    https://www2.mrc-lmb.cam.ac.uk/download/tutorial-6-linear-regression/?wpdmdl=18818&refresh=668ea3c34b12b1720624067
    31 Mar 2014: This essentially tests whether the. Tutorial 6: Linear Regression 4. model has any predictive power. ... b) Create a model to test this hypothesis, assuming a linear relationshipbetween Height and Girth.
  11. © 2005 Nature Publishing Group Endophilin and CtBP/BARS are ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndopohilinNature2005.pdf
    4 Jan 2006: Thus, a differentapproach is needed to test whether endophilin or CtBP/BARS doindeed have LPAAT activity.In a previous study1, the LPAAT activity of endophilin was. ... To test the possibility that LPAAT activity is not intrinsic toendophilin, we used a
  12. Changes in Postural Syntax Characterize Sensory Modulation and…

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-5.pdf
    14 Aug 2015: A rank sum test comparingposture probabilities during and outside of stimulation periods shows that dorsal bends areover-represented (Fig 3C) during stimulation, as previously reported for this strain [21]. ... Hits are trigrams with significantly
  13. MD1-91, MD1-92 and MD1-92-FX Morpheus II 10 mL, HT-96 and FX-96…

    https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB20.pdf
    9 Jul 2018: Figure 1. Examples of crystals obtained during initial tests with the final formulation of Morpheus II.
  14. se060101051p

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/ford01.pdf
    3 Dec 2004: test-ed by sedimentation assays using liposomesor lipid tubules (19, 27, 28). ... Each assay contained0.05 mg/ml protein. (B) Liposomes containing 10%cholesterol, 40% phosphatidylethanolamine, 40%phosphatidylcholine, and 10% of a test lipid wereprepared
  15. Thesis Chapter 0

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/Hardaker.pdf
    10 Jun 2008: To test the possible involvement of FLP-1-encoded peptides in the modulation of egg-.
  16. The structure of human thyroglobulin

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TG_Nature2020.pdf
    31 Jan 2020: Nature, doi:10.1038/s41586-020-1995-4
  17. MD1-46, MD1-47 and MD1-47-FX Morpheus 10 mL, HT-96 and FX-96…

    https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB17.pdf
    9 Jul 2018: Preliminary tests with Morpheus made within the Laboratory of Molecular Biology (LMB)1 at Cambridge, UK, have shown encouraging results with various targets.
  18. pnas201014665 19609..19610

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/PNAS-2010-Nogales-19609-10.pdf
    11 Nov 2010: 3). Just test your knowledge ofcytoskeleton structure by looking at theirfigure 4.
  19. Influence of lipid bilayer on the structure of the muscle-­type…

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnasS24.pdf
    30 Apr 2024: 121 No. 19 e2319913121 https://doi.org/10.1073/pnas.2319913121 5 of 6. to test whether nanodisc reconstitution provides a means to recapit-ulate accurately the conformations of the receptor
  20. Twinning and other pathologies Andrey Lebedev CCP4 OD-­‐structures…

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_crystallography_course_2013/lectures/pathologies_and_twinning.pdf
    11 Jun 2013: Twinning tests summary. Space group validaAon. 04/06/2013 58 Crystallography Course LMB. ... Twinning tests summary. Space group validaAon. 04/06/2013 61 Crystallography Course LMB.
  21. M410_8e 231..235

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Dynamin.pdf
    6 Mar 2001: In an effort to distinguish betweenthese two hypotheses, we designed mutants of dynamin that wouldenable us to test the relationship between dynamin's GTPase activityand its ability to support endocytosis. ... We then embedded cells asdescribed23. To
  22. httDownloaded from rsif.royalsocietypublishing.org ResearchCite this…

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-1.pdf
    4 Feb 2015: 2.12. Statistical analysisStandard statistical tests were performed using MATLAB func-tions. Correlation coefficients were calculated using theMATLAB function corrcoef. ... A value of þ1 indicates perfect positivecorrelation. A value of 21 indicates
  23. Supplementary Figure 1Lysophosphatidic acid acyl transferase (LPAAT)…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndoSupFigs.pdf
    4 Jan 2006: This software was also used for the direct fitting of simple gaussian functions to dc/dt versus s curves to test for the number of components and estimate their molecular mass.
  24. se060101051p

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/EM/ford.pdf
    3 Dec 2004: test-ed by sedimentation assays using liposomesor lipid tubules (19, 27, 28). ... Each assay contained0.05 mg/ml protein. (B) Liposomes containing 10%cholesterol, 40% phosphatidylethanolamine, 40%phosphatidylcholine, and 10% of a test lipid wereprepared
  25. Twinning and other pathologies Andrey Lebedev CCP4 OD-­‐structures…

    https://www2.mrc-lmb.cam.ac.uk/download/twinningaandaotherapathologiesa-andreyalebedeva-a/?wpdmdl=18788&refresh=668ea3bedfdf81720624062
    11 Jun 2013: Twinning tests summary. Space group validaAon. 04/06/2013 58 Crystallography Course LMB. ... Twinning tests summary. Space group validaAon. 04/06/2013 61 Crystallography Course LMB.
  26. doi:10.1016/j.pbiomolbio.2004.07.009

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/WWWrobots/PDF/Publications/Robotic_nanolitre_protein_crystallisation.pdf
    22 Sep 2017: B) Aspiration of reagents from 15 ml test tubes held in a cooled rack. ... the desired chemical/buffer from 15ml test tubes held in arack on the robot platform.
  27. se060101047p

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Itoh%20et%20al.pdf
    23 Nov 2004: MBP asa test substrate in a 50-ml reaction. ... Statistical comparisonswere made with the two-way analysis of variance(ANOVA) and two-tailed t test with Bonferroni cor-rection; P , 0.05 indicated statistical significance.
  28. Features critical for membrane binding revealed by DivIVA crystal…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/emboj201099a.pdf
    20 May 2010: membrane interaction. To test this, we purified the F17A. mutant and investigated membrane binding in vitro. ... could conveniently test suppressors for restored localization. The motivation for such screen was that suppressors of the.
  29. Membrane Localization is Critical for Activation of the PICK1 BAR…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MadsenGetherTraffic2008.pdf
    18 Oct 2008: internalized to the observed clusters. To test this, we. performed an antibody feeding experiment using FLAG–. ... These values were significantlydifferent (p < 0.0001, unpaired t-test). B) COS-7 cells expressing.
  30. 53091 361..366

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/McMahonE.pdf
    3 Dec 2004: Liposome tubulation, sedimentation and electron microscopySynthetic liposomes contained 10% cholesterol, 40% phosphatidylethanolamine,40% phosphatidylcholine, and 10% of the test lipid (in most casesphosphatidylinositol(4,5)bisphosphate).
  31. The structure of bactofilin filaments reveals their mode of membrane…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Deng2019Natmicro.pdf
    26 Aug 2019: Nature Microbiology, doi:10.1038/s41564-019-0544-0
  32. doi:10.1016/j.cell.2008.11.004

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/55_Kang_SW_Cell_2008.pdf
    21 Nov 2008: Exami-nation of differences between related species offers a glimpse at the history of evolutionary processes, but monitor-ing evolution in a test tube allows deeper exploration of these processes as
  33. Expression, purifica0on, characteriza0on, and crystalliza0on So how…

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_crystallography_course_2013/lectures/20130430_Cryst_course.pdf
    2 May 2013: Beware of the layer of cold air over the liquid nitrogen (2) Test crystal at room temp: Mitegen crystal sleeve: MicroRT Test different cryos & precipitant concentra-ons Remove any mother liqour
  34. pnas201206839 17424..17429

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/23045692.pdf
    21 Nov 2012: 2C and Fig. S2A, median abscission time of 70 min versus80 min for control treated cells; P < 0.0001, Mann–Whitneyu test). ... The differences in abscission times are significant (P < 0.0001) as determined by a Mann–Whitney u test.
  35. 15591370691369 1..30

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/elife_2019.pdf
    29 May 2019: To test whether the role of TMED10 in GFP-PrP degradation depends on complex formation, we.
  36. A Conserved Archaeal Pathway for TailAnchored Membrane Protein…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/70_Sherrill_J_Traffic_2011.pdf
    11 Nov 2011: To test this, we first determinedthe X-ray crystal structure of ADP•AlF4-bound TRC40from the methanogen Methanothermobacter thermau-totrophicus at 2.1 Å resolution (Table S1, Figure S1 andMethods). ... To test this, we used a protease-protection
  37. doi:10.1016/j.str.2007.05.002

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/FCH02F-BARHenne07.pdf
    2 Jun 2007: protein saturation on liposomes. To test more directly whether the dimer seen in the crys-. ... tutive helix. To test for a role for helix 1 in membrane bind-.
  38. Asgard archaea shed light on the evolutionary origins of the…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Hatano%20Nat%20Comms%202022.pdf
    13 Jun 2022: To test for physical interactions between these putativeESCRT-I proteins, we recombinantly expressed in E. ... To test this idea, weused size-exclusion chromatography (Fig. 3A) and SEC-MALS(Fig.
  39. doi:10.1016/j.cell.2006.03.035

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16647110.pdf
    14 Jun 2006: pounds and also test the prediction that distinct regions. of the ATP binding pocket contribute to inhibitor selectivity. ... cell culture are recapitulated in vivo by performing insulin. tolerance tests in mice.
  40. The EMBO Journal Vol.17 No.18 pp.5273–5285, 1998 Crystal structure ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Owen_McMahon1998.pdf
    9 Sep 1998: We sought to test whether this specialproperty could be explained by a change in the multimeriz-ation state of dynamin upon amphiphysin binding. ... To test the effect of the amphiphysins ondynamin multimerization, various recombinant SH3domains (5µg
  41. Molecular Biology of the CellVol. 8, 2003–2015, October 1997 ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/WiggeKohler_McMahon1997.pdf
    10 Oct 1997: To test this directly, Amph2 immunoprecipi-tates were Coomassie-stained, revealing that Amph1. ... This provided us with a useful tool to test theimportance of the heterodimer in vivo.
  42. Molecular Biology of the CellVol. 21, 3054 –3069, September ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/RVS161_MBC2010.pdf
    21 Feb 2011: To test these activities, wecoexpressed full-length Rvs161 and Rvs167 using an E. ... To-gether, our biochemical tests show that Rvs161-Rvs167 bindsto membranes and induces three-dimensional curvature.
  43. MinCD cell division proteins form alternating copolymeric cytomotive…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ncomms6341.pdf
    6 Dec 2014: 1a,d). MinC and MinD copolymerize to form an alternatingcopolymer. To experimentally test filament formation, we usedfull-length, untagged E. ... To test the effect of MinE on MinCD filaments,. we added MinE to the same experiment as described in Fig.
  44. Structure of bacterial tubulin BtubA�B:Evidence for horizontal gene…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/btubab%202005.pdf
    21 Jun 2005: To test for polymerization formation, the refoldedprotein was analyzed as described for electron microscopy.
  45. The patterned assembly and stepwise Vps4-mediated disassembly of…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Hurtig%202023%20sciadv.ade5224.pdf
    16 Jul 2023: S1E). As a further test of thisfinding, we expressed the Vps4E209Q plasmid in a cell line carryinga thymidine kinase homolog (hereafter called STK). ... 3A).To test the functional significance of this patterned assembly ofESCRT-III polymers, we used
  46. Systematic and Statistical Analysis to Aid Improvement and Validation …

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/2014_Oct_LIGANDS.pdf
    10 Oct 2014: optimise functionality; streamline feedback cycle. • Test suitability of merging up the hierarchy (when appropriate). • ... bias. Concerns Raised: • Potential for cross-validation:. – Is retaining a “test set” of molecules appropriate? –
  47. No Job Name

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MreC%20MM%202006.pdf
    7 Dec 2006: To test for dimerization invivo we turned to the bacterial two-hybrid system of Kari-mova et al. ... We thereforedecided to test whether B. subtilis MreC interacteddirectly with various PBPs.
  48. Dissertation

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/AndyHuang.pdf
    6 Mar 2008: 74. Table 4.5: The results of the significance test (p-value < 0.05 is considered to be significant).
  49. JCB: Article The Rockefeller University Press $30.00J. Cell…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/63_Rane_NS_JCB_2010.pdf
    16 Feb 2010: Fortuitously, certain disease-causing prion protein (PrP) mutants meet these requirements and afford a unique opportunity to test whether in vivo signal sequences display either appreciable inef"ciency or functional differences. ... To test this idea
  50. doi:10.1016/j.cub.2004.07.058

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15296756.pdf
    6 Oct 2004: Rap and PtdIns(3,4,5)P3 Activate ARAP3 Rho GAPActivity In VivoTo test whether a Rap family member activates ARAP3’sRho GAP activity in vivo, we performed more
  51. Phil. Trans. Roy. Soc. Lond. B. 261, 95-104 (1971) ...

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/ptrs71.pdf
    26 Nov 2012: The thin carbon film is a good phase test object (see Thon 1966) and, if the thickness of gold is correct, it displays high contrast phase detail, in which points only

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