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Scheres lab
https://www2.mrc-lmb.cam.ac.uk/groups/scheres/structures.html7 Mar 2022: Our structures. Our methods aim to open up new experimental possibilities in Structural Biology studies. By ourselves or through collaborations, we have used our methods to determine new structures. Some of these structures are described here. For -
Donald Caspar 1927 – 2021 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/donald-caspar-1927-2021/7 Jan 2022: It was Francis Crick who first recruited Don, to record some single crystal virus diffraction patterns, which he had asserted could test his theory with Jim Watson that “spherical” viruses should -
Proteins required for processing the end of mRNAs identified - MRC…
https://www2.mrc-lmb.cam.ac.uk/proteins-required-for-processing-the-end-of-mrnas-identified/17 May 2022: By reconstituting the human 3’-end processing reaction in a test tube, Vytaute showed that RBBP6 is in fact essential for the activation of human CPSF. ... The papers show the success of reconstituting complex biological processes in detail within test -
Donald Caspar (1927 – 2021) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/donald-caspar-1927-2021/5 Jan 2022: single crystal virus diffraction patterns, which he had asserted could test his theory with Jim Watson that “spherical” viruses should have cubic symmetry (tetrahedral, octahedral or icosahedral). -
LMB in vitro testing highlights bicyclic peptides (Bicycle®) as…
https://www2.mrc-lmb.cam.ac.uk/lmb-in-vitro-testing-highlights-bicyclic-peptides-bicycle-as-potential-antiviral-compounds-against-sars-cov-2/28 Apr 2022: In vitro tests of their proprietary bicyclic peptide show promise for antiviral modality against SARS-CoV-2. -
Refactoring the genetic code to create organisms protected by a…
https://www2.mrc-lmb.cam.ac.uk/refactoring-the-genetic-code-to-create-organisms-protected-by-a-genetic-firewall/24 Oct 2022: To test whether the newly engineered cells were resistant to viral infection, the team collaborated with George Salmond’s group in the University of Cambridge Department of Biochemistry. -
Blocking action of intestinal immune cell enhances the immune…
https://www2.mrc-lmb.cam.ac.uk/blocking-action-of-intestinal-immune-cell-enhances-the-immune-response-to-colorectal-cancer/7 Jun 2022: Further tests on human CRC tissue, provided by Simon Buczacki at Addenbrooke’s Hospital, Cambridge (now at the Nuffield Department of Surgical Sciences, University of Oxford), revealed a similar relationship between -
Engineered polymerase enzyme presents new opportunity for quick and…
https://www2.mrc-lmb.cam.ac.uk/engineered-polymerase-enzyme-presents-new-opportunity-for-quick-and-efficient-modified-nucleic-acid-synthesis/13 Oct 2022: Capability tests of this improved enzyme found that it is substantially faster than previous engineered ‘progenitor’ or ‘parent’ polymerases, while retaining equal fidelity for making XNAs. -
https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/downloads/protocols
https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/downloads/M4S_activities.pdf11 Mar 2022: Lugol solution is a solution of iodine and potassium iodide in water and it is used as an indicator test for the presence of starches, with which it reacts by turning -
Clinical study reveals striking daily temperature variation in the…
https://www2.mrc-lmb.cam.ac.uk/clinical-study-reveals-striking-daily-temperature-variation-in-the-human-brain-that-predicts-survival-after-brain-injury/13 Jun 2022: HEATWAVE is already being used to test how daily variation in human brain temperature interacts with molecular ‘clocks’ within human brain cells, aiming to better understand temperature as a circadian timing -
Tripodi Lab
https://www2.mrc-lmb.cam.ac.uk/groups/tripodi/feed/3 May 2022: I will argue that manipulating these pathways and test what happens to the individual action-emtokens /emof the action-sequence is a way to ask the mouse to define what are -
Asgard archaea shed light on the evolutionary origins of the…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Hatano%20Nat%20Comms%202022.pdf13 Jun 2022: To test for physical interactions between these putativeESCRT-I proteins, we recombinantly expressed in E. ... To test this idea, weused size-exclusion chromatography (Fig. 3A) and SEC-MALS(Fig. -
Mechanism of signal sequence handover from NAC to SRP on ribosomes…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Science_2022.pdf27 Feb 2022: To test this, we compared the affinity ofNAC for RNCs displaying either an ER signalsequence (RNCSS) or a mutated signal sequencethat inhibits ER targeting (RNCSSmt) (fig. ... S17, B and C). Thus, thecontact between NAC UBA and SRP54 NG do-mains -
PNAS202120006_proof
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/pnas%20Lee%202022.pdf18 Dec 2022: To test thesehypotheses, we used the same N-terminal Brn1 release assay(Fig.
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