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13 Sep 2021: The project will inform the development, and test the feasibility of novel therapeutic strategies to treat heart failure. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

13 Sep 2021: This is why we need to use living animals to understand the complexity of the disease process and test the potential effect of new treatments. ... We will continue to test other non-animal strategies with the aim to replace the use of animals.

13 Sep 2021: We therefore wish to test if defects of the mouse EIF2AK4 gene can also be worsened by lung inflammation. ... be shown, and some account of the tests of significance to be made and the treatment differences that are to be estimated).

13 Sep 2021: Hence, medical conditions of the oesophagus represent an important social and economic burden, with a significant proportion of our public health budget spent in treatments that are inefficient and, in most ... 4. Test experiments, called pilot

13 Sep 2021: Some animals in this project will be subjected to calorie restriction or exercise or behavioural tests, which are expected to cause no more than temporary stress until the animals have acclimatised. ... Whenever feasible and scientifically appropriate,

13 Sep 2021: We can test many combinations of cells and materials in culture this way in order to optimise how we regenerate damaged hearts. ... This strategy of testing engineered heart tissues in culture will again reduce the number of animals finally used in the

13 Sep 2021: malfunctioning causes diseases and test whether they can be used to cure or treat disease. ... We also plan to test the effectiveness of new therapies based around ubiquitin ligase biology in tumour transplantation models.

13 Sep 2021: To identify genes responsible for coloration differences we will test if it is possible to interbreed different species with different colour patterns using in vitro fertilisation methods. ... Gene modifications are confirmed by collecting tissue

13 Sep 2021: mice, and; 4) in some cases, we will surgically transplant modified breast cells into the cleared breast tissue (Fatpad) of mice to test the effect of the certain genetic mutations on

13 Sep 2021: Because targets for these diseases are developing we are mostly focusing on helping the client with proof of concept studies, developing cell based assays to test their compounds in and then ... The techniques used for dosing with test agents and

13 Sep 2021: Validate modes of action by modifying targets in transgenic parasites to specifically test these ideas. • ... Additionally, there is currently no alternative to animal species that can be used to test with regards to vaccine or drug sensitivity studies

13 Sep 2021: By doing so, we can test the activity of our new drug candidates on tumour growth in a more relevant way in a live animal. ... Our organization regularly uses a range of in vitro (taking place in a test tube or laboratory dish, outside a living animal)

13 Sep 2021: prevent unnecessary suffering, we also use non-interventional behavioural tests to measure the impact of arthritis/colitis on an animal’s behaviour.

13 Sep 2021: Our research will study how and where the bacteria hide in the body to resist to vaccines and antibiotics and will test new innovative vaccines.

13 Sep 2021: To get a better understanding of the models we will test known anti-cancer drugs to determine how well the tumours respond to therapies.

13 Sep 2021: Thus, mental health disorders place a considerable burden on not only the affected individual, but also social and economic burdens on society.

13 Sep 2021: This will create new opportunities to test new therapies that can stop bad inflammation. ... After the identification of targets, we will then proceed to test our results in our mouse models of disease.

13 Sep 2021: The number of animals that will undergo surgery will depend on the number of factors that we plan to test over the course of the project, but we envisage to use

13 Sep 2021: short periods up to 4 hours of water restriction before behavioural tests.

13 Sep 2021: In order to overcome these limitations and to provide a more ethical way to test smelling behaviour in mice, an automated testing apparatus called AutonoMouse has been recently developed.