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30 Apr 2024: licence. Furthermore, when possible, we will generate primary cell lines from mouse brains which will allow us to test some of our hypotheses in vitro prior to performing elaborate experiments that ... 1) We will perform pilot studies and in vitro tests

20 Aug 2021: We used computer-based mathematical descriptions of brain activity to make specific predictions that require fewer animals to test. ... For this reason, the majority of our behavioural tests involve positive reward rather than punishment, in order to

30 Apr 2024: This will create new opportunities to test new therapies that can stop inflammation, brain damage, and the subsequent development of neuropsychiatric disorders in the offspring. ... This has allowed us to test whether treatments will be (1) safe for

30 Apr 2024: After this she may undergo a glucose tolerance test (as described in point 5) prior to her being humanely killed and her tissues collected and stored for laboratory analyses. ... c) Glucose or insulin tolerance tests which require injection of either

30 Apr 2024: We also want to test whether subcutaneous implants can be used to accurately monitor body temperature in the mice.

20 Aug 2021: Pilot studies involve using a small number of mice to test the safety and efficacy of a method before using it on a larger number of mice.

19 Aug 2021: Over the same period, behavioural tests will be carried out once a week to test their ability to remain on a rotating cylinder and to cross a narrow beam. ... the expected number of studies to validate and test potential drugs for each project.

13 Sep 2021: To identify genes responsible for coloration differences we will test if it is possible to interbreed different species with different colour patterns using in vitro fertilisation methods. ... Gene modifications are confirmed by collecting tissue

13 Sep 2021: Validate modes of action by modifying targets in transgenic parasites to specifically test these ideas. • ... Additionally, there is currently no alternative to animal species that can be used to test with regards to vaccine or drug sensitivity studies

19 Aug 2021: For example, phenotypes that we find in genetically altered embryos are confirmed by direct comparisons to control (un-altered) animals following the same test conditions. ... All of our experiments are designed to use only the number of animals needed

18 Jun 2021: Then towards the end of the study we might perform a glucose tolerance test using an intraperitoneal (this means into the abdominal cavity) glucose injection. ... Before the glucose and insulin tolerance tests mice will be fasted for up to 6 hours.

29 Apr 2024: We aim to test the use of the mouse grimace scale for each protocol (https://nc3rs.org.uk/grimacescales).

13 Sep 2021: Because targets for these diseases are developing we are mostly focusing on helping the client with proof of concept studies, developing cell based assays to test their compounds in and then ... The techniques used for dosing with test agents and

13 Sep 2021: Thus, mental health disorders place a considerable burden on not only the affected individual, but also social and economic burdens on society.

13 Sep 2021: To get a better understanding of the models we will test known anti-cancer drugs to determine how well the tumours respond to therapies.

29 Apr 2024: World Health Organisation, General Medical Council, Royal College of Veterinary Surgeons) and pharmaceutical organisations who may develop policies, diagnostic tests and therapies to combat sub/infertility, pregnancy complications and. ... It also

13 Sep 2021: prevent unnecessary suffering, we also use non-interventional behavioural tests to measure the impact of arthritis/colitis on an animal’s behaviour.

30 Apr 2024: During the in vivo (performed in or on living animals) experiment, blood sample will be taken to test the generation of an antigen specific antibody response.

20 Aug 2021: Fresh tissue is required by the client to run in vitro experiments to further the understanding of what causes disease and to test how drugs work. ... The client requires mice that have had their genes modified so that they can investigate what causes

13 Sep 2021: By doing so, we can test the activity of our new drug candidates on tumour growth in a more relevant way in a live animal. ... Our organization regularly uses a range of in vitro (taking place in a test tube or laboratory dish, outside a living animal)