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Development of nerve neuroprosthetic treatment
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_nerve_neuroprosthetic_treatments_non-technical_summary_redacted.pdf29 Apr 2024: This includes engineering tests (testing devices on the bench), computer models, and cell culture tests. ... The experimenter can make use of this to test devices aimed to restore similar deficits in patients. -
The diversity of glia in health, development and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_diversity_of_glia_in_health_development_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: In this study, we will test potential treatments for Pelizaeus-Merzbacher disease, which currently has no cure. ... Behavior test: Assessment of cognitive, sensory and motor coordination might be done for mice developing phenotypes. -
Discovery and development of treatments for immunological diseases
https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_and_development_of_treatments_for_immunological_diseases_non-technical_summary_redacted.pdf29 Apr 2024: To develop and validate animal models that can further our understanding of basic mechanisms involved in immunological disease and enable us to test new therapeutic agents. ... goal by enabling us to test new therapeutic hypothesis in vivo relevant to -
Nutrient sensing in the brain
https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf30 Apr 2024: These are useful to test sensing mechanisms with a number of different assays. ... In this model, we can test nutrients or hormones and measure a number of metrics relevant to brain function. -
Platelets as a therapeutic tool
https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf30 Apr 2024: What's the aim of this project? To fully test and understand how good platelets (blood cells that help stop bleeding) made from stem cells are at stopping bleeding. ... We are generating platelets from stem cells in the laboratory and need to test how -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... the action of test agents, and well as the variability in replicating the disease. -
Provision of an outsourced drug discovery platform for metabolic and…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_metabolic_and_cardiovascular_diseases_non-te_redacted.pdf30 Apr 2024: They will also identify test agents which are not suitable for further development. ... This expert regularly tests the tool against peer-reviewed power calculators and can adjust as necessary. -
Exploring Bioelectronic Approaches to Nervous System Restoration in…
https://www.ubs.admin.cam.ac.uk/system/files/public/exploring_bioelectronic_approaches_to_nervous_system_restoration_in_large_animals_non-technical_sum_redacted.pdf30 Apr 2024: These tests showed that the devices work well in recording nerve activity and helping to control how nerves work. ... For example, we do a lot of computer simulations, which helps us test fewer things in living animals. -
Models of mitochondrial diseases, pathogenesis and therapy
https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf30 Apr 2024: The knowledge gained will be used to develop and test of novel therapeutic interventions. ... Live animals are required to test in vivo therapies. Wherever possible, animals will be killed prior to tissue harvest. -
Cartilage repair and replacement
https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf29 Apr 2024: 4 or less). Followed by longer (e.g. 3, 6, 12 or 24 months), larger studies (less than 10 animals per test group at each time point).
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