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30 Apr 2024: Why were they not suitable? It is not possible to entirely replace animal experiments for this project since it is important to test whether the principles identified in cell culture are

19 Aug 2021: This project will develop and test novel protective drugs for heart attack and stroke, as well as the resulting organ damage of chronic heart failure or chronic neurological disability, in order ... The main aim of the license is to test protective

30 Apr 2024: This will allow us to change the signalling within particular cells and test the consequences on the mechanics and development of the whole organ. ... Why were they not suitable? It is not possible to entirely replace animal experiments for this project

30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and

30 Apr 2024: This work will make extensive use of pilot studies, as most of the test substances will be by definition novel, as they concern novel technologies or modalities (method of treatment). ... Pilot or tolerability studies will be carried out for new models

13 Sep 2021: We can test many combinations of cells and materials in culture this way in order to optimise how we regenerate damaged hearts. ... This strategy of testing engineered heart tissues in culture will again reduce the number of animals finally used in the

29 Apr 2024: A small subset of mice will undergo a blood test to check how much of a certain marker of interest they have (for example, a protein). ... The best, non-invasive way to monitor disease progression is to test the urine for protein.

18 Jun 2021: To test how effective vaccines are, pups will be infected with the viruses when adults. ... We will test all new medicines for treating virus infection in cells in the laboratory first, and only progress to animal experiments if positive results are

13 Sep 2021: malfunctioning causes diseases and test whether they can be used to cure or treat disease. ... We also plan to test the effectiveness of new therapies based around ubiquitin ligase biology in tumour transplantation models.

30 Apr 2024: Renal function can be assessed by tests performed in urine or blood collected from the animals. ... For example we use human kidney organoids to test drug activity in certain projects.

29 Apr 2024: This will contribute to a reduction in the burden of developmental origins of heart disease, thereby having a positive clinical, economic and societal impact on health. ... The real ethical, biological and economic value of the avian relative to other

29 Apr 2024: We primarily use adult female mice, hamsters and guinea pigs to test our vaccines. ... There exists no cell-based model or less sentient model to test vaccines.

18 Jun 2021: 4. Test experiments, called pilot experiments, will be used to calculate the amount of a substance that we can safely inject into the animal. ... These test experiments will help us to work out how much this amount is but will only use a small number of

20 Aug 2021: The effects monitored in a similar way for example using a combination of the following: observation of general health and behaviour, regular blood tests, non-invasive imaging (e.g. ... Any models developed to test instruments or materials will take

18 Jun 2021: test interventions at early stages that decrease the severity of the disease and help the development of treatments. ... The same behavioural and gut function tests and endpoints will be applied as described above.

13 Sep 2021: mice, and; 4) in some cases, we will surgically transplant modified breast cells into the cleared breast tissue (Fatpad) of mice to test the effect of the certain genetic mutations on

30 Apr 2024: rodent models to test how well they remain detectable and/or functional over a defined period of time. ... The information gathered here will inform us which drug is best suited to take forward to test in the target animal species.

30 Apr 2024: endoscopy, bronchoscopy, MRI/CT/PET) and non imaging techniques (e.g. blood tests and functional assays).

18 Jun 2021: We will use this knowledge to develop and test new treatment strategies for pulmonary arterial hypertension and other related conditions. ... the length of the total process until we test the level of disease is 7 weeks.

18 Jun 2021: In the long-term (5-7 years), we expect that the findings of this study will result in the design of at least 1 human clinical trial to test the safety ... The purpose here will be to induce a disease, such as liver failure or diabetes, to test the