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Uncovering the molecular basis of triage during protein synthesis -…
https://www2.mrc-lmb.cam.ac.uk/uncovering-molecular-basis-triage-protein-synthesis/20 Jan 2017: To answer this question, Susan Shao, a former postdoc in Manu’s lab, worked with Monica Rodrigo-Brenni and Maryann Kivlen to biochemically rebuild this triage reaction in a test tube -
LMB welcomes Emmanuel Derivery as new Group Leader - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/lmb-welcomes-emmanuel-derivery-new-group-leader/17 Nov 2016: Ultimately, my plan is to use flies as test tubes to increase our understanding of mammalian systems, potentially allowing restoration of asymmetric divisions in situations where it has been lost. -
A map to show the way to sense smell, temperature, and humidity - MRC …
https://www2.mrc-lmb.cam.ac.uk/a-map-to-show-the-way-to-sense-smell-temperature-and-humidity/23 Jul 2020: Producing maps of how these neurons connect with each other allows scientists to build and test theories to explain how complex behaviours can arise from electrochemical signalling across neural circuits. -
A new directed evolution technique to unlock the potential of XNAs -…
https://www2.mrc-lmb.cam.ac.uk/a-new-directed-evolution-technique-to-unlock-the-potential-of-xnas/20 Jul 2020: Alongside applications in research, this capacity is also used for medical tests, such as to test for the presence of viral RNA, including in COVID-19 tests. -
2021 Max Perutz Lecture to be given by David Baker - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/2021-max-perutz-lecture-to-be-given-by-david-baker/20 Apr 2021: SARS-COV2 provided a test of the relevance of these methods to real-world challenges. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/12947
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/12947Visitors could view u2018mini-brainsu2019 in a dish and find out how these brain organoids are used to study brain development, and then test their matching skills in the u2018Where is -
Christy Russell receives General Certificate in Occupational Health…
https://www2.mrc-lmb.cam.ac.uk/christy-russell-receives-general-certificate-in-occupational-health-and-safety/22 May 2024: That was hard work. Each evening, I was also completing test tasks in a similar format to the exam. -
Donald Caspar (1927 – 2021) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/donald-caspar-1927-2021/5 Jan 2022: single crystal virus diffraction patterns, which he had asserted could test his theory with Jim Watson that “spherical” viruses should have cubic symmetry (tetrahedral, octahedral or icosahedral). -
Testing the capacity for intracellular antibodies to neutralise…
https://www2.mrc-lmb.cam.ac.uk/testing-the-capacity-for-intracellular-antibodies-to-neutralise-sars-cov-2/29 Jul 2021: Further, standard tests that measure the activity of anti-S antibodies against the virus are unable to assess the virus-neutralising capacity of anti-N antibodies. ... Developing an assay to test for intracellular anti-viral activity of anti-N antibodies -
The LMB welcomes Albert Cardona as a new Group Leader - MRC…
https://www2.mrc-lmb.cam.ac.uk/the-lmb-welcomes-albert-cardona-as-a-new-group-leader/2 Dec 2019: Albert’s group then plan to use this information to develop and experimentally test theoretical models that can explain the variety of animal behaviours elicited by different stimuli. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11827
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11827Visitors could view u2018mini-brainsu2019 in a dish and find out how these brain organoids are used to study brain development, and then test their matching skills in the u2018Where is -
Behind the Scenes with... Steve Scotcher - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/share-your-memories/steve-scotcher/31 Mar 2021: More recently, I’ve worked with Richard Henderson and Greg McMullan on various high vacuum test rigs for the new breed of digital EM (electron microscopy) detectors, which is really exciting -
Effects of caffeine on the human circadian clock - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/effects-of-caffeine-on-the-human-circadian-clock/17 Sep 2015: Trials are needed to test the latter, and it will be important to monitor for caffeine-induced sleep disruption under such conditions, which could worsen jet lag. -
A synthetic molecule that can restore lost connections in the brain - …
https://www2.mrc-lmb.cam.ac.uk/a-synthetic-molecule-that-can-restore-lost-connections-in-the-brain/28 Aug 2020: As well as observing reconnection of synapses, the team were able to measure improvements in behavioural tests, with restored motor coordination in cerebellar ataxia, better performance in memory tests in mouse -
Contents:
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/proshade/tutorial_proshade.html30 Jan 2019: The following screenshot shows the result for the test map EMD_1290.. -
STEM in Song - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/news-and-events/public-engagement/events-at-the-lmb/stem-in-song/21 Jul 2023: Visitors could view ‘mini-brains’ in a dish and find out how these brain organoids are used to study brain development, and then test their matching skills in the ‘Where is -
LMB Congratulates John Gurdon on Nobel Prize Announcement - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-congratulates-john-gurdon-on-nobel-prize-announcement/8 Oct 2012: While here he continued to develop the use of Xenopus oocytes as a living test tube, demonstrating synthesis of haemoglobin from injected mRNA, and of 5S rRNA from injected DNA, as -
How the earliest life on Earth may have replicated itself - MRC…
https://www2.mrc-lmb.cam.ac.uk/how-the-earliest-life-on-earth-may-have-replicated-itself/16 May 2018: To test this theory of an ‘RNA world’, scientists have been trying to recreate a self-replicating RNA in the laboratory. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/13500
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/13500{"id":13500,"date":"2018-12-21T11:09:54","date_gmt":"2018-12-21T11:09:54","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?page_id=13500"},"modified":"2023-07-21T12:53:12","modified_gmt":"2023-07-21T11:53:12","slug":"lmb-365","status":"publish","t -
TRIM21 links antibody and T cell immunity to combat viral infection - …
https://www2.mrc-lmb.cam.ac.uk/trim21-links-antibody-and-t-cell-immunity-to-combat-viral-infection/4 Dec 2020: It has been known for many years that our immune system produces antibodies against viral nucleoproteins and measuring the presence of these antibodies has become a standard rapid diagnostic test to -
Over 50 LMB scientists showcase research at the Cambridge Science…
https://www2.mrc-lmb.cam.ac.uk/over-50-lmb-scientists-showcase-research-at-the-cambridge-science-festival/27 Mar 2014: test their detective skills with the stereomicroscope challenge. ... to test their scientific skills in their containment hood speed pipetting game. -
Discovery of the genetic basis of a rare immune disease - MRC…
https://www2.mrc-lmb.cam.ac.uk/discovery-of-the-genetic-basis-of-a-rare-immune-disease/22 Oct 2013: A simple genetic test can tell if the patient has the mutation or not. -
LMB showcases the beauty of the microscopic world at the Cambridge…
https://www2.mrc-lmb.cam.ac.uk/lmb-showcases-the-beauty-of-the-microscopic-world-at-the-cambridge-festival/31 Mar 2023: Participants could see their own cheek cells under the microscope and test their detective skills in an interactive game. -
From the scientist’s view: a conversation with… Buzz Baum - MRC…
https://www2.mrc-lmb.cam.ac.uk/life-at-the-lmb/profiles/from-the-scientists-view-a-conversation-with-buzz-baum/15 Dec 2023: Now, Buzz’s group works to further test this theory using archaeal cells as a model to study evolution. ... I spent years after that, trying to test the model directly. -
How flies use smell to determine the identity and position of other…
https://www2.mrc-lmb.cam.ac.uk/how-flies-use-smell-to-determine-the-identity-and-position-of-other-flies/25 May 2023: Using genetically engineered flies, the group were able to test the hypotheses they derived from their wiring map. -
Network control principles predict neuron function in the C. elegans…
https://www2.mrc-lmb.cam.ac.uk/network-control-principles-predict-neuron-function-c-elegans-connectome/19 Oct 2017: To test the predictions, Denise Walker in Bill’s group used a laser microbeam to specifically kill individual neurons predicted to be important for controllability, as well as some related neurons -
LMB showcases the diversity of science at the Cambridge Science…
https://www2.mrc-lmb.cam.ac.uk/lmb-showcases-the-diversity-of-science-at-the-cambridge-science-festival/28 Mar 2018: Visitors could view ‘mini-brains’ in a dish and find out how these brain organoids are used to study brain development, and then test their matching skills in the ‘Where is -
Atomic structure of chromosomal complex responsible for organising…
https://www2.mrc-lmb.cam.ac.uk/atomic-structure-of-chromosomal-complex-responsible-for-organising-dna-determined/4 Nov 2021: In order to test whether the mode of DNA binding revealed by cryo-EM also occurs in cells, Frank genetically engineered E. -
Refactoring the genetic code to create organisms protected by a…
https://www2.mrc-lmb.cam.ac.uk/refactoring-the-genetic-code-to-create-organisms-protected-by-a-genetic-firewall/24 Oct 2022: To test whether the newly engineered cells were resistant to viral infection, the team collaborated with George Salmond’s group in the University of Cambridge Department of Biochemistry. -
Christian Münch Receives British Neuroscience Association…
https://www2.mrc-lmb.cam.ac.uk/christian-munch-receives-british-neuroscience-association-postgraduate-award/15 Dec 2011: During his PhD work, Christian studied what causes aggregation of mutant SOD1 in the test tube and in cells. -
Understanding the protein modifications behind Trim-Away protein…
https://www2.mrc-lmb.cam.ac.uk/understanding-the-protein-modifications-behind-trim-away-protein-degradation-technology/17 Apr 2023: To directly test if TRIM21 N-terminal ubiquitination is required for TRIM21 function, Leo Kiss in collaboration with Jonas Weidenhausen in Irmgard Sinning’s lab at the University of Heidelberg developed -
Day of celebration as Her Majesty The Queen opens the new LMB…
https://www2.mrc-lmb.cam.ac.uk/day-of-celebration-as-her-majesty-the-queen-opens-the-new-lmb-building/23 May 2013: UK’s economic competitiveness. -
Liz Miller: Signed, sealed, delivered - protein trafficking in the…
https://www2.mrc-lmb.cam.ac.uk/liz-miller-signed-sealed-delivered-protein-trafficking-in-the-endoplasmic-reticulum/13 Oct 2020: Despite Liz having the security of tenure, she and Marcus started looking for other places to live and work, as the economic climate meant that it was unlikely that Marcus would -
Opening of LMB Containment Level 3 lab fast-tracked to help fight the …
https://www2.mrc-lmb.cam.ac.uk/opening-of-lmb-containment-level-3-lab-fast-tracked-to-help-fight-the-covid-19-pandemic/23 Oct 2020: I have also started working on a new project with Radu Aricescu and Jan Löwe to test new vaccine candidates. ... Our facility can be of use to pharmaceutical companies working on new treatment strategies and fast diagnostic tests and we are already in -
Mesolens Microscopy (2009) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/research/technology-transfer/recent-technology-transfer-initiatives/mesolens-microscopy-2009/21 Jul 2023: A test centre for Mesoscopy has been set up in the University of Strathclyde, and commercial production of microscopes based on this technology is planned. -
refmac keywords
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/refmac/refmac_keywords.html6 Oct 2014: refmac keywords (version 5.5.0026 and later). Please note that most of these keywords were in the previous versions also. Some of the keywords were implemented as user requests. The numbers inside the brackets (if present) after the keyword -
Advanced understanding of how suprachiasmatic nucleus regulates the…
https://www2.mrc-lmb.cam.ac.uk/advanced-understanding-of-how-suprachiasmatic-nucleus-regulates-the-bodys-circadian-rhythm/9 Sep 2021: These tests exposed how the signalling network across the SCN changes over day and night. -
HIV exploits a native cellular molecule to increase the stability of…
https://www2.mrc-lmb.cam.ac.uk/hiv-exploits-a-native-cellular-molecule-to-increase-the-stability-of-its-capsid/31 May 2018: Finally, Donna teamed up with Adolfo Saiardi to devise a way to test whether IP. -
Unravelling the replisome: how a molecular machine overcomes…
https://www2.mrc-lmb.cam.ac.uk/unravelling-the-replisome-how-a-molecular-machine-overcomes-obstacles-to-dna-replication/4 May 2020: on a section of DNA in a test tube, before solving the structure using electron cryo-microscopy (cryo-EM) and mass spectrometry. -
Blocking action of intestinal immune cell enhances the immune…
https://www2.mrc-lmb.cam.ac.uk/blocking-action-of-intestinal-immune-cell-enhances-the-immune-response-to-colorectal-cancer/7 Jun 2022: Further tests on human CRC tissue, provided by Simon Buczacki at Addenbrooke’s Hospital, Cambridge (now at the Nuffield Department of Surgical Sciences, University of Oxford), revealed a similar relationship between -
Engineered polymerase enzyme presents new opportunity for quick and…
https://www2.mrc-lmb.cam.ac.uk/engineered-polymerase-enzyme-presents-new-opportunity-for-quick-and-efficient-modified-nucleic-acid-synthesis/13 Oct 2022: Capability tests of this improved enzyme found that it is substantially faster than previous engineered ‘progenitor’ or ‘parent’ polymerases, while retaining equal fidelity for making XNAs. -
Anne Bertolotti: Finding clues to combat neurodegenerative disease -…
https://www2.mrc-lmb.cam.ac.uk/life-at-the-lmb/profiles/anne-bertolotti-finding-clues-to-combat-neurodegenerative-disease/21 Jul 2023: she says inadvertently became a test for how the LMB would perceive someone who wanted to be both a mother and a scientist. -
From bench to blockbuster: the story of HUMIRA® – best-selling drug…
https://www2.mrc-lmb.cam.ac.uk/news-and-events/lmb-exhibitions/from-bench-to-blockbuster-the-story-of-humira-best-selling-drug-in-the-world/21 Jul 2023: test adalimumab as a treatment for rheumatoid arthritis. ... Examples include: cancer diagnosis; HIV diagnosis, blood group tests, transplant compatibility, pregnancy tests and more recently, COVID lateral flow tests. -
MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2F&format=xmlmessage||t.value)&&!/[a-zA-Z0-9]/.test(t.secret)){for(var ... new -
Novel technology useful for development of gene and drug therapies…
https://www2.mrc-lmb.cam.ac.uk/novel-technology-useful-for-development-of-gene-and-drug-therapies-licensed-to-local-company/10 Sep 2013: In order to develop such therapeutics, it is necessary to test a wide variety of peptide-cargo combinations to determine the optimal peptide for delivery of the drug cargo for the ... This new technology enhances the speed of the early stage drug -
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2…
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fvenki-ramakrishnan-world-economic-forum-davos%2F -
Functionalized graphene sheets on gold grids aid structure…
https://www2.mrc-lmb.cam.ac.uk/functionalized-graphene-sheets-on-gold-grids-aid-structure-determination-by-electron-cryo-microscopy/19 Jun 2019: The team were also able to have different modifications in different regions of the support grid, which will allow scientists to test a defined set of different modifications in a reproducible -
Liz Miller: Signed, sealed, delivered – protein trafficking in the…
https://www2.mrc-lmb.cam.ac.uk/life-at-the-lmb/profiles/liz-miller-signed-sealed-delivered-protein-trafficking-in-the-endoplasmic-reticulum/21 Jul 2023: Despite Liz having the security of tenure, she and Marcus started looking for other places to live and work, as the economic climate meant that it was unlikely that Marcus would -
Privacy & Cookies - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fcookies%2F&format=xmlt||t.secret||t.message||t.value)&&!/[a-zA-Z0-9]/.test(t.secret)){for(var ... s.getAttribute("src")),n=new -
Research - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fresearch%2F&format=xmlsecret||t.message||t.value)&&!/[a-zA-Z0-9]/.test(t.secret)){for(var ... src")),n=new
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