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30 Apr 2024: Why were they not suitable? It is not possible to entirely replace animal experiments for this project since it is important to test whether the principles identified in cell culture are

19 Aug 2021: This project will develop and test novel protective drugs for heart attack and stroke, as well as the resulting organ damage of chronic heart failure or chronic neurological disability, in order ... The main aim of the license is to test protective

30 Apr 2024: This will allow us to change the signalling within particular cells and test the consequences on the mechanics and development of the whole organ. ... Why were they not suitable? It is not possible to entirely replace animal experiments for this project

30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and

30 Apr 2024: This work will make extensive use of pilot studies, as most of the test substances will be by definition novel, as they concern novel technologies or modalities (method of treatment). ... Pilot or tolerability studies will be carried out for new models

13 Sep 2021: We can test many combinations of cells and materials in culture this way in order to optimise how we regenerate damaged hearts. ... This strategy of testing engineered heart tissues in culture will again reduce the number of animals finally used in the

29 Apr 2024: A small subset of mice will undergo a blood test to check how much of a certain marker of interest they have (for example, a protein). ... The best, non-invasive way to monitor disease progression is to test the urine for protein.

18 Jun 2021: To test how effective vaccines are, pups will be infected with the viruses when adults. ... We will test all new medicines for treating virus infection in cells in the laboratory first, and only progress to animal experiments if positive results are

13 Sep 2021: malfunctioning causes diseases and test whether they can be used to cure or treat disease. ... We also plan to test the effectiveness of new therapies based around ubiquitin ligase biology in tumour transplantation models.

30 Apr 2024: Renal function can be assessed by tests performed in urine or blood collected from the animals. ... For example we use human kidney organoids to test drug activity in certain projects.