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  2. Redefining the importance of astrocytes in the brain’s master body…

    https://www2.mrc-lmb.cam.ac.uk/redefining-the-importance-of-astrocytes-in-the-brains-master-body-clock/
    Thumbnail for Redefining the importance of astrocytes in the brain’s master body clock - MRC Laboratory of Molecular Biology 11 Jan 2019: in neurons of the SCN revealed that the animals were on slightly different cycles: astrocyte-driven rhythms were found to be approximately one hour shorter, reflecting the specific cell-autonomous features ... Francis Crick Avenue, Cambridge Biomedical
  3. Two LMB papers chosen as major historical landmarks in research - MRC …

    https://www2.mrc-lmb.cam.ac.uk/two-lmb-papers-chosen-as-major-historical-landmarks-in-research/
    Thumbnail for Two LMB papers chosen as major historical landmarks in research - MRC Laboratory of Molecular Biology 17 Mar 2015: It was the first time a complete set of synaptic connections in the nervous system of an animal had been determined. ... Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
  4. Transgenic mice expressing human P301S tau protein (continued success …

    https://www2.mrc-lmb.cam.ac.uk/research/technology-transfer/recent-technology-transfer-initiatives/transgenic-mice-expressing-human-p301s-tau-protein-continued-success-since-2002/
    Thumbnail for Transgenic mice expressing human P301S tau protein (continued success since 2002) - MRC Laboratory of Molecular Biology 21 Jul 2023: At five to six months of age, homozygous animals develop motor symptoms characterised by severe lower limb paralysis. ... Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
  5. SiR (Self-inactivating Rabies virus) - A new tool to study neural…

    https://www2.mrc-lmb.cam.ac.uk/research/technology-transfer/recent-technology-transfer-initiatives/sir-self-inactivating-rabies-virus-a-new-tool-to-study-neural-networks-2017/
    Thumbnail for SiR (Self-inactivating Rabies virus) - A new tool to study neural networks (2017) - MRC Laboratory of Molecular Biology 21 Jul 2023: Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
  6. Instinctive and learned responses to smells are controlled by a…

    https://www2.mrc-lmb.cam.ac.uk/instinctive-and-learned-responses-to-smells-are-controlled-by-a-single-brain-circuit-in-flies/
    Thumbnail for Instinctive and learned responses to smells are controlled by a single brain circuit in flies - MRC Laboratory of Molecular Biology 20 Sep 2018: As well as having instinctive responses to their environment, nearly all animals can learn to associate particular sights, smells, or sounds with rewards or negative consequences. ... Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH,
  7. Madeline Lancaster: The accidental organoid - mini-brains as models…

    https://www2.mrc-lmb.cam.ac.uk/madeline-lancaster-the-accidental-organoid-mini-brains-as-models-for-human-brain-development/
    Thumbnail for Madeline Lancaster: The accidental organoid - mini-brains as models for human brain development - MRC Laboratory of Molecular Biology 11 Feb 2020: If we can get cells from an animal we can reprogramme them to pluripotent stem cells and use them to make brain organoids. ... They’re already seeing differences that make sense, particularly those that reflect size differences in the actual brains of
  8. Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and…

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-4.pdf
    30 Jun 2015: The number of animals analyzed is indicated for each genotype. Error barsindicate SEM. ... Thenumber of animals analyzed is indicated for each genotype. Error bars indicate SEM.
  9. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Nature_2017.pdf
    13 Jan 2017: 2.0. YFP. /CFP. rat. io. Time (s). d. a. fRMG Immobilized animals. ... 21% O2; n = 4 assays, 120 animals. P < 0.01, Mann–Whitney Utest.
  10. From the scientist’s view: a conversation with ... Marta Zlatic - MRC …

    https://www2.mrc-lmb.cam.ac.uk/life-at-the-lmb/profiles/from-the-scientists-view-a-conversation-with-marta-zlatic/
    Thumbnail for From the scientist’s view: a conversation with ... Marta Zlatic - MRC Laboratory of Molecular Biology 21 Jul 2023: She studied Natural Sciences at Trinity College, Cambridge, followed by a Masters in Chemistry. ... What inspired you to choose this particular area of science/research? I was always fascinated by animal behaviour.
  11. httDownloaded from rsif.royalsocietypublishing.org ResearchCite this…

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-1.pdf
    4 Feb 2015: Confidenceintervals were estimated with bootstrap sampling of the data.Specifically, we resampled the population of animals with replace-ment, then for each animal resampled recordings of that animalif there was more ... n – q) Same, but for a control
  12. From the scientist’s view: a conversation with… Buzz Baum - MRC…

    https://www2.mrc-lmb.cam.ac.uk/life-at-the-lmb/profiles/from-the-scientists-view-a-conversation-with-buzz-baum/
    Thumbnail for From the scientist’s view: a conversation with… Buzz Baum - MRC Laboratory of Molecular Biology 15 Dec 2023: immediately felt like we made a good decision, because they do it in a way that’s like an animal cell, like a cancer cell. ... Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
  13. Biomarker identified by David Komander’s group and collaborators…

    https://www2.mrc-lmb.cam.ac.uk/biomarker-identified-by-david-komanders-group-and-collaborators-offers-new-hope-for-foot-and-mouth-detector/
    Thumbnail for Biomarker identified by David Komander’s group and collaborators offers new hope for foot-and-mouth detector - MRC Laboratory of Molecular Biology 15 Mar 2018: Published on. 15 March, 2018. A new discovery by David Komander’s group and collaborators could allow scientists to detect animals infected with the foot-and-mouth disease virus (FMDV) and ... Francis Crick Avenue, Cambridge Biomedical Campus,
  14. New technique identifies protein production in specific cells at…

    https://www2.mrc-lmb.cam.ac.uk/new-technique-identifies-protein-production-in-specific-cells-at-specific-times/
    Thumbnail for New technique identifies protein production in specific cells at specific times - MRC Laboratory of Molecular Biology 17 Apr 2014: Individual sets of cells in the body of an animal are specialised to do different things. ... Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
  15. Thesis Chapter 0

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/Hardaker.pdf
    10 Jun 2008: constants [Waggoner et al. 1998]. In this egg-laying pattern, animals fluctuate between. ... the eggs laid by each animals were counted. Plates in which the animal had crawled off the.
  16. Structure of a post-catalytic human spliceosome improves…

    https://www2.mrc-lmb.cam.ac.uk/structure-of-a-post-catalytic-human-spliceosome-improves-understanding-of-splicing-control/
    Thumbnail for Structure of a post-catalytic human spliceosome improves understanding of splicing control - MRC Laboratory of Molecular Biology 1 Feb 2019: This is the first multicellular animal-specific protein to be found in the active site of the spliceosome. ... This work was funded by the MRC, ERC, EMBO, Marie Sklodowska-Curie Actions, and a Cambridge-Rutherford Memorial PhD Scholarship.
  17. Madeline Lancaster awarded the Cheryll Tickle Medal from the British…

    https://www2.mrc-lmb.cam.ac.uk/madeline-lancaster-awarded-the-cheryll-tickle-medal-from-the-british-society-for-developmental-biology/
    Thumbnail for Madeline Lancaster awarded the Cheryll Tickle Medal from the British Society for Developmental Biology - MRC Laboratory of Molecular Biology 6 Sep 2023: Today, the organisation is committed to the advancement of research and teaching of animal and plant biology as it relates to developmental processes, furthering public education and bringing together scientists interested ... Francis Crick Avenue,
  18. Mariann Bienz: Fascinating flies - Drosophila and the molecular…

    https://www2.mrc-lmb.cam.ac.uk/mariann-bienz-fascinating-flies-drosophila-and-the-molecular-biology-of-development-and-disease/
    Thumbnail for Mariann Bienz: Fascinating flies - Drosophila and the molecular biology of development and disease - MRC Laboratory of Molecular Biology 8 Oct 2019: of genes could give rise to positional information able to dictate the body plan of an animal. ... I was completely uprooted – my English was rotten, I knew no-one in Cambridge.
  19. Jason William Chin Page 1 of 18 MRC Laboratory ...

    https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-content/uploads/2024/01/Chin-cv-26012024.pdf
    29 Jan 2024: BSS Seminar, Cavendish Laboratory, Cambridge, January 26th 2018. ISCB, Geneva, Plenary Lecture, January 12th 2018. ... 83) Genetic code expansion and bioorthogonal labeling enables cell specific proteomics in an animal.
  20. Activating the kinase protein PI3Kα revealed as a potential…

    https://www2.mrc-lmb.cam.ac.uk/activating-the-kinase-protein-pi3ka-revealed-as-a-potential-therapeutic-target-to-protect-and-regenerate-cells/
    Thumbnail for Activating the kinase protein PI3Kα revealed as a potential therapeutic target to protect and regenerate cells - MRC Laboratory of Molecular Biology 24 May 2023: Using animal models, they demonstrated that short-term administration of 1938 can achieve therapeutic benefits in protecting hearts from dying after injury and increasing the ability of neurons to regenerate. ... Bart Vanhaesebroeck and Richard Angell
  21. Mental health training programme earns national recognition for two…

    https://www2.mrc-lmb.cam.ac.uk/archive/articles/Mental_health_training_programme.pdf
    13 Mar 2014: pages with Cambridge Newcentres in the community or the closure of doctors surgeries. ... Featuring puzzles fromthe past. Animal Rescue. Can you give anabandoned pet a home?
  22. Technician Commitment Evaluating Impact through Self-Assessment & …

    https://www2.mrc-lmb.cam.ac.uk/wordpress/?wpdmdl=35486&ind=1689941624667
    26 Jul 2023: the divisions (Figure 1). The main LMB building also hosts the Cambridge University. ... on the Cambridge Biomedical Campus, and the Ares animal facility is located at the.
  23. Alessio Vagnoni awarded David Sainsbury Fellowship for work on…

    https://www2.mrc-lmb.cam.ac.uk/alessio-vagnoni-awarded-david-sainsbury-fellowship-for-work-on-neuronal-ageing-in-a-non-mammalian-model/
    Thumbnail for Alessio Vagnoni awarded David Sainsbury Fellowship for work on neuronal ageing in a non-mammalian model - MRC Laboratory of Molecular Biology 8 Mar 2016: The Fellowship is awarded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), a leading independent scientific organisation dedicated to replacing, refining and reducing the ... Francis Crick Avenue,
  24. Organization of spines on the dendritesof Purkinje cellsJohn O’Brien…

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnas06.pdf
    25 Jul 2006: Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom. ... The dendriticshafts of the wild-type animal were generally more torturous andvariable in thickness than those of the weaver mutant.
  25. Madeline Lancaster: The accidental organoid - mini-brains as models…

    https://www2.mrc-lmb.cam.ac.uk/life-at-the-lmb/profiles/madeline-lancaster-the-accidental-organoid-mini-brains-as-models-for-human-brain-development/
    Thumbnail for Madeline Lancaster: The accidental organoid - mini-brains as models for human brain development - MRC Laboratory of Molecular Biology 21 Jul 2023: If we can get cells from an animal we can reprogramme them to pluripotent stem cells and use them to make brain organoids. ... They’re already seeing differences that make sense, particularly those that reflect size differences in the actual brains of
  26. Cryo-EM structure of a cholinergic cell membrane reveals importance…

    https://www2.mrc-lmb.cam.ac.uk/cryo-em-structure-of-a-cholinergic-cell-membrane-reveals-importance-of-cholesterol-in-neuromuscular-transmission/
    Thumbnail for Cryo-EM structure of a cholinergic cell membrane reveals importance of cholesterol in neuromuscular transmission - MRC Laboratory of Molecular Biology 22 Aug 2022: The newly-identified lipid non-fluid ‘skin’ is likely to be a recurring motif in cholesterol-enriched regions of animal cell membranes. ... 2024 MRC Laboratory of Molecular Biology,. Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH
  27. INVITED REVIEW Mechanosensory molecules and circuits in C. elegans ...

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-2.pdf
    10 Dec 2014: A number of animal senses, including touch, hearing, andproprioception, involve the control of sensory neuron activityby mechanical force. ... TMC genes encodemultipass integral membrane proteins and are broadly con-served in animals [48, 42].
  28. Dissertation

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/AndyHuang.pdf
    6 Mar 2008: animals [1, 3]. Table 1.1 contains descriptions of behaviors of these mutants. ... animals, collecting data one animal at a time is often frustratingly slow.
  29. JFCregg_OGS_finaledit

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/Cregg_thesis.pdf
    14 Dec 2010: From far too idyllic. UCSD to the famed Laboratory of Molecular Biology in Cambridge, England, to. ... you meet along the way. My experiences in Cambridge allowed me the opportunity to.
  30. pq240013132p

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/16_Wilhelm_JE_PNAS_2000.pdf
    10 Nov 2000: 1995) Development (Cambridge, U.K.). 121, 2737–2746.9. Gavis, E. R. & Lehmann, R. ... L. & Macdonald, P. M. (1993) Development. (Cambridge, U.K.) 119, 169 –178.14.
  31. Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/COVID%20vaccine%202021%201873-3468.14171.pdf
    29 Aug 2021: Correspondence. L. C. James and J. Lowe, MRC Laboratory. of Molecular Biology, Cambridge Biomedical. ... Home Office Animals (Scientific Procedures) Act (ASPA,. 1986), and approved by the UKRI Animal Welfare and.
  32. doi:10.1016/j.ceb.2003.11.005

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cocb%202003.pdf
    27 Nov 2003: In fungi and animal cells, but apparently not in plants, thedivision plane is first defined by a ring assembled fromseptin filaments [22,23]. ... Some of the cytoskeleton proteins involved in cytokinesis. (a)Representation of a section through an animal
  33. CURRICULUM VITAE

    https://www2.mrc-lmb.cam.ac.uk/groups/bienz/wp-content/uploads/sites/23/BienzCV_March2024.pdf
    11 Apr 2024: 1990 Promoted to Associate Professor. 1991 Senior Staff Member, MRC LMB, Cambridge, UK. ... 2018-2023 Deputy Director, MRC LMB, Cambridge, UK. Awards:. 1981-1984 EMBO Long-Term Fellowship.
  34. Structure of a cholinergic cell membraneNigel Unwina,1 Edited by ...

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnasS22.pdf
    4 Nov 2022: Author affiliations: aMedical Research Council Laboratoryof Molecular Biology, CB2 0QH, Cambridge, UnitedKingdom. ... This could be a common occur-rence, since cholesterol typically constitutes 30–40 mol % ofthe total lipids in animal cell membranes (35
  35. pgen.1004082 1..13

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/84_Chen_C_PlosGen_2014.pdf
    24 Sep 2015: The phenotypes of odr-8 mutants closely resemble those of odr-4defective animals [20]. ... 38 ccGFP-positive F1 animals weresingled, and genotyped after the eggs were laid.
  36. A Large Particle Associated with the Perimeter of the ...

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/jcb82.pdf
    5 Jul 2010: P. N. T. UNWIN and R. A. MILLIGANDepartment of Structural Biology, Stanford University Medical School, Stanford, California 94305; andMedical Research Council Laboratory of Molecular Biology, Cambridge, England. ... J. Microscopie. 6:371-390. 31. Watson,
  37. x15959u064

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Reim_Brose2001.pdf
    17 Mar 2003: In the present study, we use double deletion mutant‖ Present address: MRC Laboratory of Molecular Biology, Neurobiol-mice to demonstrate that CPXs are important positiveogy Division, Hills Road, Cambridge CB2 2QH, ... animals) (Figure 6B). Thus,
  38. Amphiphysin is necessaryfor organization of the…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/DroxAmph.pdf
    9 Nov 2001: 1Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK; 2Department of Biochemistry, Universityof Cambridge, Cambridge CB2 1QW, UK; 3Medical Research Council Laboratory of Molecular Biology, Cambridge CB22QH, UK; 4Multi-Imaging
  39. The life of proteins: the good, the mostly good and the ugly

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/68_Morimoto_RI_NSMB_2011.pdf
    7 Jan 2011: David Ron (University of Cambridge, UK) reported on a role for the ER–localized peroxiredoxin 4 (PRDX4) in disulfide bond formation. ... However, research on animals harboring mutations in ERO1 uncovered PRDX4’s role in disulfide bond formation and
  40. doi:10.1016/j.cell.2006.03.035

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16647110.pdf
    14 Jun 2006: regulation of the p85 subunit that is observed in heterozy-. gous animals (Brachmann et al., 2005). ... Animals were fasted to normalize. blood glucose levels and then challenged with insulin.
  41. Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of …

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/CircGen_2019.pdf
    1 Dec 2019: Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, United Kingdom (M.H.K., R.S.H.). ... Animal models for ASNA1-mediated TA protein insertion related genes …………….….34. SUPPLEMENTAL FIGURES.
  42. “The LMB provides an unsurpassed environment for both new ...

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/www2.mrc-lmb.cam.ac.uk/?wpdmdl=18852
    18 Jan 2021: elegans is first animal to have genome sequenced. 2017-2018: Structures of tau filaments from Alzheimer’s and. ... 1986: C. elegans is the first animal to have its. entire nervous system mapped.
  43. doi:10.1016/j.devcel.2008.06.015

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/54_Rane_NS_DevCell_2008.pdf
    18 Sep 2008: Furthermore, since the first. four pairs of microsomes are from animals before any phenotype. ... Because the potential pheno-. types of these animals could not necessarily be predicted, we.
  44. Mapping the human kidney - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fmapping-the-human-kidney%2F&format=xml
    A lack of tissue availability has limited research into human kidney function and animal research hasn’t translated into treatments for human patients. ... Menna Clatworthy’s group, in the University of Cambridge Molecular Immunity Unit, which is
  45. Membrane transport between compartments in eukary-otic cells requires …

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Dynaminreview2004.pdf
    2 Feb 2004: Figure 1 | Dynamin-superfamily members in animals and plants. We have subdivided thedynamin superfamily into ‘classical dynamins’ and ‘dynamin-related proteins’. ... Mitofusin/Fzo1 Mitochondrial outer membrane Mitochondrial fusion and division.
  46. IntroductionThe endosomal system functions as an internal…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/SNX2Cullen2005.pdf
    17 Jan 2006: Biology, Hills Road, Cambridge CB2 2QH, UK3Cell Microscopy Center, Department of Cell Biology and Institute for Biomembranes, University Medical Centre Utrecht, Utrecht, The Netherlands4Signalling Programme, The Babraham Institute, Babraham Hall,
  47. Dynamin architecture—from monomer to polymer

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/dynaminreviewCOSBILow2010.pdf
    21 Oct 2010: evolutionary kingdoms. Address. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH,. ... 2010 Elsevier Ltd. All rights reserved. DOI 10.1016/j.sbi.2010.09.011. IntroductionDynamins form a large family of proteins of great
  48. The structure of human thyroglobulin

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TG_Nature2020.pdf
    31 Jan 2020: 1MRC Laboratory of Molecular Biology, Cambridge, UK. 2Jožef Stefan Institute, Ljubljana, Slovenia.
  49. GB-9-7-229-Amos_9.qxd

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/gb-2008-9-7-229.pdf
    4 Aug 2008: 2008 BioMed Central Ltd. GGeennee oorrggaanniizzaattiioonn aanndd eevvoolluuttiioonnaarryy hhiissttoorryyGenes for tektins are found throughout the animal kingdom. ... animals, including mammals. Dense fibers do not occur in. cilia, or in the flagella of
  50. ANALYSIS Integrating molecular and network biologyto decode…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Schmid_Nature2007.pdf
    22 Aug 2007: 2a)7,8,23,24. 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. ... We observe that most participatingproteins are conserved in the animal kingdom (Table 1 and Supple-mentary Information Part 4).
  51. doi:10.1016/j.biocel.2008.08.010

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cytomotive2008Lowe.pdf
    17 Sep 2008: AmosRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. ... Mol Microbiol2004;52:385–98. ggert US, Mitchison TJ, Field CM. Animal cytokinesis: from parts list to mechanisms.Annu Rev Biochem 2006;75:543–66.

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