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“The LMB provides an unsurpassed environment for both new ...
https://www2.mrc-lmb.cam.ac.uk/?wpdmdl=1885218 Jan 2021: elegans is first animal to have genome sequenced. 2017-2018: Structures of tau filaments from Alzheimer’s and. ... 1986: C. elegans is the first animal to have its. entire nervous system mapped. -
Changes in Postural Syntax Characterize Sensory Modulation and…
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-5.pdf14 Aug 2015: thus, enumerating an animal's complete repertoire of shape transitions would provide a. ... 2. Lehner PN. Handbook of ethological methods. 2nd ed. Cambridge ; New York: Cambridge UniversityPress; 1996. -
Mental health training programme earns national recognition for two…
https://www2.mrc-lmb.cam.ac.uk/archive/articles/Mental_health_training_programme.pdf13 Mar 2014: pages with Cambridge Newcentres in the community or the closure of doctors surgeries. ... Featuring puzzles fromthe past. Animal Rescue. Can you give anabandoned pet a home? -
Technician Commitment Evaluating Impact through Self-Assessment & …
https://www2.mrc-lmb.cam.ac.uk/wordpress/?wpdmdl=35486&ind=168994162466726 Jul 2023: the divisions (Figure 1). The main LMB building also hosts the Cambridge University. ... on the Cambridge Biomedical Campus, and the Ares animal facility is located at the. -
Jason William Chin Page 1 of 18 MRC Laboratory ...
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-content/uploads/2024/01/Chin-cv-26012024.pdf29 Jan 2024: BSS Seminar, Cavendish Laboratory, Cambridge, January 26th 2018. ISCB, Geneva, Plenary Lecture, January 12th 2018. ... 83) Genetic code expansion and bioorthogonal labeling enables cell specific proteomics in an animal. -
IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Nature_2017.pdf13 Jan 2017: 2.0. YFP. /CFP. rat. io. Time (s). d. a. fRMG Immobilized animals. ... 21% O2; n = 4 assays, 120 animals. P < 0.01, Mann–Whitney Utest. -
Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and…
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-4.pdf30 Jun 2015: The number of animals analyzed is indicated for each genotype. Error barsindicate SEM. ... Thenumber of animals analyzed is indicated for each genotype. Error bars indicate SEM. -
httDownloaded from rsif.royalsocietypublishing.org ResearchCite this…
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-1.pdf4 Feb 2015: Confidenceintervals were estimated with bootstrap sampling of the data.Specifically, we resampled the population of animals with replace-ment, then for each animal resampled recordings of that animalif there was more ... n – q) Same, but for a control -
Thesis Chapter 0
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/Hardaker.pdf10 Jun 2008: constants [Waggoner et al. 1998]. In this egg-laying pattern, animals fluctuate between. ... the eggs laid by each animals were counted. Plates in which the animal had crawled off the. -
pq240013132p
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/16_Wilhelm_JE_PNAS_2000.pdf10 Nov 2000: 1995) Development (Cambridge, U.K.). 121, 2737–2746.9. Gavis, E. R. & Lehmann, R. ... L. & Macdonald, P. M. (1993) Development. (Cambridge, U.K.) 119, 169 –178.14. -
Organization of spines on the dendritesof Purkinje cellsJohn O’Brien…
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnas06.pdf25 Jul 2006: Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom. ... The dendriticshafts of the wild-type animal were generally more torturous andvariable in thickness than those of the weaver mutant. -
“The LMB provides an unsurpassed environment for both new ...
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/www2.mrc-lmb.cam.ac.uk/?wpdmdl=1885218 Jan 2021: elegans is first animal to have genome sequenced. 2017-2018: Structures of tau filaments from Alzheimer’s and. ... 1986: C. elegans is the first animal to have its. entire nervous system mapped. -
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/COVID%20vaccine%202021%201873-3468.14171.pdf29 Aug 2021: Correspondence. L. C. James and J. Lowe, MRC Laboratory. of Molecular Biology, Cambridge Biomedical. ... Home Office Animals (Scientific Procedures) Act (ASPA,. 1986), and approved by the UKRI Animal Welfare and. -
pgen.1004082 1..13
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/84_Chen_C_PlosGen_2014.pdf24 Sep 2015: The phenotypes of odr-8 mutants closely resemble those of odr-4defective animals [20]. ... 38 ccGFP-positive F1 animals weresingled, and genotyped after the eggs were laid. -
INVITED REVIEW Mechanosensory molecules and circuits in C. elegans ...
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-2.pdf10 Dec 2014: A number of animal senses, including touch, hearing, andproprioception, involve the control of sensory neuron activityby mechanical force. ... TMC genes encodemultipass integral membrane proteins and are broadly con-served in animals [48, 42]. -
JFCregg_OGS_finaledit
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/Cregg_thesis.pdf14 Dec 2010: From far too idyllic. UCSD to the famed Laboratory of Molecular Biology in Cambridge, England, to. ... you meet along the way. My experiences in Cambridge allowed me the opportunity to. -
Dissertation
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/AndyHuang.pdf6 Mar 2008: animals [1, 3]. Table 1.1 contains descriptions of behaviors of these mutants. ... animals, collecting data one animal at a time is often frustratingly slow. -
The life of proteins: the good, the mostly good and the ugly
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/68_Morimoto_RI_NSMB_2011.pdf7 Jan 2011: David Ron (University of Cambridge, UK) reported on a role for the ER–localized peroxiredoxin 4 (PRDX4) in disulfide bond formation. ... However, research on animals harboring mutations in ERO1 uncovered PRDX4’s role in disulfide bond formation and -
CURRICULUM VITAE
https://www2.mrc-lmb.cam.ac.uk/groups/bienz/wp-content/uploads/sites/23/BienzCV_March2024.pdf11 Apr 2024: 1990 Promoted to Associate Professor. 1991 Senior Staff Member, MRC LMB, Cambridge, UK. ... 2018-2023 Deputy Director, MRC LMB, Cambridge, UK. Awards:. 1981-1984 EMBO Long-Term Fellowship. -
doi:10.1016/j.devcel.2008.06.015
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/54_Rane_NS_DevCell_2008.pdf18 Sep 2008: Furthermore, since the first. four pairs of microsomes are from animals before any phenotype. ... Because the potential pheno-. types of these animals could not necessarily be predicted, we. -
doi:10.1016/j.ceb.2003.11.005
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cocb%202003.pdf27 Nov 2003: In fungi and animal cells, but apparently not in plants, thedivision plane is first defined by a ring assembled fromseptin filaments [22,23]. ... Some of the cytoskeleton proteins involved in cytokinesis. (a)Representation of a section through an animal -
x15959u064
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Reim_Brose2001.pdf17 Mar 2003: In the present study, we use double deletion mutant‖ Present address: MRC Laboratory of Molecular Biology, Neurobiol-mice to demonstrate that CPXs are important positiveogy Division, Hills Road, Cambridge CB2 2QH, ... animals) (Figure 6B). Thus, -
doi:10.1016/j.cell.2006.03.035
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16647110.pdf14 Jun 2006: regulation of the p85 subunit that is observed in heterozy-. gous animals (Brachmann et al., 2005). ... Animals were fasted to normalize. blood glucose levels and then challenged with insulin. -
A Large Particle Associated with the Perimeter of the ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/jcb82.pdf5 Jul 2010: P. N. T. UNWIN and R. A. MILLIGANDepartment of Structural Biology, Stanford University Medical School, Stanford, California 94305; andMedical Research Council Laboratory of Molecular Biology, Cambridge, England. ... J. Microscopie. 6:371-390. 31. Watson, -
Amphiphysin is necessaryfor organization of the…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/DroxAmph.pdf9 Nov 2001: 1Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK; 2Department of Biochemistry, Universityof Cambridge, Cambridge CB2 1QW, UK; 3Medical Research Council Laboratory of Molecular Biology, Cambridge CB22QH, UK; 4Multi-Imaging -
Structure of a cholinergic cell membraneNigel Unwina,1 Edited by ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnasS22.pdf4 Nov 2022: Author affiliations: aMedical Research Council Laboratoryof Molecular Biology, CB2 0QH, Cambridge, UnitedKingdom. ... This could be a common occur-rence, since cholesterol typically constitutes 30–40 mol % ofthe total lipids in animal cell membranes (35 -
Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/CircGen_2019.pdf1 Dec 2019: Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, United Kingdom (M.H.K., R.S.H.). ... Animal models for ASNA1-mediated TA protein insertion related genes …………….….34. SUPPLEMENTAL FIGURES. -
GB-9-7-229-Amos_9.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/gb-2008-9-7-229.pdf4 Aug 2008: 2008 BioMed Central Ltd. GGeennee oorrggaanniizzaattiioonn aanndd eevvoolluuttiioonnaarryy hhiissttoorryyGenes for tektins are found throughout the animal kingdom. ... animals, including mammals. Dense fibers do not occur in. cilia, or in the flagella of -
Membrane transport between compartments in eukary-otic cells requires …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Dynaminreview2004.pdf2 Feb 2004: Figure 1 | Dynamin-superfamily members in animals and plants. We have subdivided thedynamin superfamily into ‘classical dynamins’ and ‘dynamin-related proteins’. ... Mitofusin/Fzo1 Mitochondrial outer membrane Mitochondrial fusion and division. -
IntroductionThe endosomal system functions as an internal…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/SNX2Cullen2005.pdf17 Jan 2006: Biology, Hills Road, Cambridge CB2 2QH, UK3Cell Microscopy Center, Department of Cell Biology and Institute for Biomembranes, University Medical Centre Utrecht, Utrecht, The Netherlands4Signalling Programme, The Babraham Institute, Babraham Hall, -
Dynamin architecture—from monomer to polymer
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/dynaminreviewCOSBILow2010.pdf21 Oct 2010: evolutionary kingdoms. Address. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH,. ... 2010 Elsevier Ltd. All rights reserved. DOI 10.1016/j.sbi.2010.09.011. IntroductionDynamins form a large family of proteins of great -
ANALYSIS Integrating molecular and network biologyto decode…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Schmid_Nature2007.pdf22 Aug 2007: 2a)7,8,23,24. 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. ... We observe that most participatingproteins are conserved in the animal kingdom (Table 1 and Supple-mentary Information Part 4). -
pone.0052401 1..15
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Podosome2012/journal.pone.0052401.pdf10 Jan 2013: Addenbrooke’s Hospital, Cambridge, United Kingdom. Abstract. Cell motility, adhesion and phagocytosis are controlled by actin and membrane remodelling processes. ... anti-Endophilin1 and 2 antibodies (ZYMED Laboratories, Invi-. trogen respectively). -
doi:10.1016/j.cub.2004.09.077
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Snx1PeteCullen2004/Snx1PeteCullen2004.pdf23 Nov 2004: Mol. Biol. Cell 15, 721–733.for Medical Research, Cambridge, UK). Secondary antibodies conju- 6. ... Mol.Cell. Biol. 18, 7278–7287.Matthew Seaman (Cambridge Institute for Medical Research, Cam-. -
, 130081, published 7 August 20133 2013 Open Biol. ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Open%20Biol.-2013-TakedaCombined.pdf25 Sep 2013: Biology, Francis Crick Avenue, Cambridge CB2. 0QH, UK. Electronic supplementary material is available. ... In yeast and in animal cells,PI(4,5)P2 localizes to the cleavage furrow and plays importantregulatory roles in cytokinesis [29]. -
Supplementary Text & Figs
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Schmid_Nature2007Sup.pdf22 Aug 2007: Eva M. Schmid and Harvey T. McMahon. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. ... observed that conservation of endocytic proteins through the animal kingdom was high. -
doi:10.1016/j.biocel.2008.08.010
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cytomotive2008Lowe.pdf17 Sep 2008: AmosRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. ... Mol Microbiol2004;52:385–98. ggert US, Mitchison TJ, Field CM. Animal cytokinesis: from parts list to mechanisms.Annu Rev Biochem 2006;75:543–66. -
740 Research Paper Calcium triggers calcineurin-dependent synaptic…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Marks_McMahon1998.pdf21 Mar 2003: Address: MRC Laboratory of Molecular Biology,Hills Road, Cambridge CB2 2QH, UK. ... Also we would like to thankTheresa Langford and the animal unit staff for their support. -
The structure of human thyroglobulin
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TG_Nature2020.pdf31 Jan 2020: 1MRC Laboratory of Molecular Biology, Cambridge, UK. 2Jožef Stefan Institute, Ljubljana, Slovenia. -
doi:10.1016/j.molcel.2004.08.004
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15350214.pdf24 Sep 2004: al., 2000; Verbsky et al.,Cambridge CB2 1PD2002; York et al., 1999). ... In addition, animal IP3-3Ksvesicular trafficking, channel regulation, cell prolifera- also have a conserved Ca2/Calmodulin (CAM) bindingtion, and a variety of nuclear functions -
cdf672 6935..6943
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ParM%20EMBO%20F-actin%202002.pdf30 Dec 2002: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB22QH, UK and 1Department of Biochemistry and Molecular Biology,University of Southern Denmark, DK-5230 Odense M, Denmark. ... Theaddition of new subunits to the ends of laments maymove the -
pnas201206839 17424..17429
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/23045692.pdf21 Nov 2012: Lamersa, Roger L. Williamsa,2, and Juan Martin-Serranob. aLaboratory of Molecular Biology, Medical Research Council, Cambridge CB2 0QH, United Kingdom; and bDepartment of Infectious Diseases, King’s CollegeLondon School of ... Nat Cell Biol -
Abstract_Book_HMM_v2
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/conferences/JM_Abstract_Book.pdf15 Sep 2011: 09:50-10:20 Harvey McMAHON (Cambridge, United Kingdom). Molecular determinants of membrane fusion and fission Déterminants moléculaires de la fusion et de la fission des membranes. ... Hills Road, UK-Cambridge CB2 0HQ, United Kingdom 2 Department of -
elifesciences.org van den Ent et al. eLife 2014;3:e02634. DOI: ...
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/mrebdouble2014.pdf6 Jun 2014: 1Structural Studies Division, Medical Research Council - Laboratory of Molecular Biology, Cambridge, United Kingdom; 2Protein and Nucleic Acid Chemistry Division, Medical Research Council - Laboratory of Molecular Biology, Cambridge, United Kingdom. -
Structure of a Bacterial Dynamin-like Protein Lipid Tube Provides a…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cell%202009%20dynamin.pdf19 Dec 2009: Low,1,2, Carsten Sachse,1 Linda A. Amos,1 and Jan Löwe1,1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK2Present address: School of Crystallography, Birkbeck College, Malet ... which is expected given the high level of divergence -
Amos&Schlieper.indd
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Amos%26Schlieper.pdf16 Nov 2005: MICROTUBULES AND MAPs. By LINDA A. AMOS AND DANIEL SCHLIEPERMRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. -
Tumour prevention by a single antibody domaintargeting the…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17568777.pdf22 Jul 2007: Tomoyuki Tanaka, Roger L Williamsand Terence H Rabbitts. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK. ... R Berks for animal experiments, E Obayashi forpRKHISTEV and TEV protease, and R Grenfell for cell sorting,and also thank Elena -
elifesciences.org Szwedziak et al. eLife 2014;3:e04601. DOI:…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/FtsZ_Piotr_eLife_2014.pdf31 Dec 2014: Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom. ... When bacterial and animal cells divide, they must constrict their membrane inwards to split a single cell into two. -
The structure of bactofilin filaments reveals their mode of membrane…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Deng2019Natmicro.pdf26 Aug 2019: Articleshttps://doi.org/10.1038/s41564-019-0544-0. 1MRC Laboratory of Molecular Biology, Cambridge, UK. 2These authors contributed equally: Xian Deng, Andres Gonzalez Llamazares. -
Qrb1300006 1..40
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/qrb13.pdf30 Jul 2013: Nicotinic acetylcholinereceptorandthestructuralbasisofneuromuscular transmission:insightsfromTorpedopostsynapticmembranes. Nigel UnwinMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. ... Avenue, Cambridge CB2 0QH, UK. Tel:
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