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  2. AWERB Sub-Standing Committee Meeting Minutes - 5th March 2021

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_050321_redacted.pdf
    7 Dec 2022: Minutes of AWERB Standing Committee meeting 24/02/21 The minutes were not available 4.
  3. AWERB Sub-Standing Committee Meeting Minutes - 10th January 2020

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_100120_redacted_0.pdf
    7 Dec 2022: Further information added in regards to weight loss persisting for 24 hours in Protocol 16. •
  4. Multi-tissue mechanics in the development and engineering of the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/multi-tissue_mechanics_in_the_development_and_engineering_of_the_posterior_body_axis_non-technical_redacted.pdf
    30 Apr 2024: Note that in this. PPL number: | Granted: 24 Oct 23 | Expires: 24 Oct 28. ... The number of. PPL number: | Granted: 24 Oct 23 | Expires: 24 Oct 28.
  5. PPL number: | Granted: 30 Jul 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/neural_regulation_of_fertility_nts_expires2024_redacted.pdf
    13 Sep 2021: PPL number: | Granted: 30 Jul 19 | Amended: 17 Aug 21 | Expires: 29 Jul 24.
  6. Nutrient sensing in the brain

    https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 12 Jan 22 | Amended: 03 Feb 24 | Expires: 12 Jan 27. ... The PPL holder will be required to disclose:. PPL number: | Granted: 12 Jan 22 | Amended: 03 Feb 24 | Expires: 12 Jan 27.
  7. Cartilage repair and replacement

    https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf
    29 Apr 2024: Animals will also be individually housed (but within close proximity and line of sight to the rest of the 'flock') in the 24-48 hours prior to surgery. ... 4 or less). Followed by longer (e.g. 3, 6, 12 or 24 months), larger studies (less than 10 animals
  8. PPL number: | Granted: 06 Aug 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/mice_with_transgenic_immunoglobulin_loci_nts_redacted.pdf
    20 Aug 2021: PPL number: | Granted: 06 Aug 19 | Amended: 20 Nov 20 | Expires: 05 Aug 24. ... this mice will be anaesthetised during dosing and will be given suitable pain relief until they return to normal roughly 24-48 hours later.
  9. Mechanisms of organ development and disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_of_organ_development_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 25 Oct 23 | Amended: 29 Feb 24 | Expires: 25 Oct 28. ... Refinement. PPL number: | Granted: 25 Oct 23 | Amended: 29 Feb 24 | Expires: 25 Oct 28.
  10. AWERB 3Rs Minutes 5th July 2023 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_050723_redacted.pdf
    14 May 2024: Highlights of AWERB Standing meeting 24/05/23 None. 10. Highlights of January AOC meeting 19/05/23 None.
  11. In vivo compressive forces (non-technical summary)_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf
    30 Apr 2024: The neural crest cells are formed over approximately 24 hours. This means that we can put the intact embryo under a specialised microscope and can easily image the whole process of
  12. Molecular mechanisms of tolerance and immunosuppression…

    https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_tolerance_and_immunosuppression_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 20 Apr 23 | Amended: 24 Aug 23 | Expires: 20 Apr 28. ... be. PPL number: | Granted: 20 Apr 23 | Amended: 24 Aug 23 | Expires: 20 Apr 28.
  13. PPL number: | Granted: 07 Aug 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/microglial_targets_in_brain_pathology_and_ageing_nts_redacted.pdf
    20 Aug 2021: PPL number: | Granted: 07 Aug 19 | Expires: 06 Aug 24.
  14. PPL number: | Granted: 03 Jul 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/regeneration_in_the_nervous_system_nts_expires2024_redacted.pdf
    13 Sep 2021: PPL number: | Granted: 03 Jul 19 | Amended: 09 Sep 21 | Expires: 14 Jan 24. ... Contains severe procedures. Objectives and benefits. PPL number: | Granted: 03 Jul 19 | Amended: 09 Sep 21 | Expires: 14 Jan 24.
  15. Interaction between the immune system and tumours (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf
    30 Apr 2024: Tumour organoids do have more of. PPL number: | Granted: 03 Jan 24 | Expires: 03 Jan 29. ... Animals that enter experimental. PPL number: | Granted: 03 Jan 24 | Expires: 03 Jan 29.
  16. Proteotoxicity in development and ageing (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/proteotoxicity_in_development_and_ageing_non-technical_summary_redacted.pdf
    30 Apr 2024: In summary, mice will be aged up to the age of 24 months. ... Some genetically altered mice will be maintained for ageing until they reach a maximum of 24 months of age.
  17. Potent monoclonal antibodies for biologics discovery (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/potent_monoclonal_antibodies_for_biologics_discovery_non-technical_summary_redacted.pdf
    30 Apr 2024: This can benefit a wider scientific community. PPL number: | Granted: 08 Mar 24 | Expires: 08 Mar 29. ... Mice. Mild Severity - 100%. Moderate severity - 0%. Rats. PPL number: | Granted: 08 Mar 24 | Expires: 08 Mar 29.
  18. Code of Practice for the Housing and Care of ...

    https://www.ubs.admin.cam.ac.uk/files/cop_housing_care_for_sci_purp.pdf
    18 Sep 2015: 5.1 Accommodation specifications 22. Section 1, Chapter 3: Rabbits 24 – 261 Accommodation specifications 24. ... 1.1 Doe plus litter 241.2 Breeding animals and post-weaned stock 241.3 Rabbits being used in procedures 24.
  19. AWERB 3Rs Minutes 1st March 2023 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_010323_redacted.pdf
    14 May 2024: If an animal does not improve within. 72 hours then they may not be euthanised for a further 24 hours.
  20. Cancer and its microenvironment! From mechanisms to translation…

    https://www.ubs.admin.cam.ac.uk/system/files/public/cancer_and_its_microenvironment_from_mechanisms_to_translation_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 25 Jan 23 | Amended: 24 Jan 24 | Expires: 25 Jan 28. ... lung. PPL number: | Granted: 25 Jan 23 | Amended: 24 Jan 24 | Expires: 25 Jan 28.
  21. Biobehavioural basis of the individual vunerability to impulsive…

    https://www.ubs.admin.cam.ac.uk/system/files/public/biobehavioural_basis_of_the_individual_vulnerability_to_impulsivecompulsive_spectrum_disorders_redacted.pdf
    29 Apr 2024: PPL number: | Granted: 14 Jan 22 | Amended: 24 Jan 22 | Expires: 14 Jan 27. ... with. PPL number: | Granted: 14 Jan 22 | Amended: 24 Jan 22 | Expires: 14 Jan 27.
  22. Pharmacological evaluation of imaging agents and development of…

    https://www.ubs.admin.cam.ac.uk/system/files/public/pharmacological_evaluation_of_imaging_agents_and_development_of_imaging_applications_and_methods_no_redacted.pdf
    30 Apr 2024: Production of the candidate imaging agent. PPL number: | Granted: 16 Feb 24 | Expires: 16 Feb 29. ... Mice. Non-recovery: 64%. Mild: 36%. Moderate: 0%. Severe: 0%. Rats. PPL number: | Granted: 16 Feb 24 | Expires: 16 Feb 29.
  23. PPL number: | Granted: 18 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/generation_of_novel_antibodies_with_therapeutic_potential_nts_redacted.pdf
    20 Aug 2021: What's the aim of this project? PPL number: | Granted: 18 Nov 19 | Expires: 18 Nov 24. ... Refinement. PPL number: | Granted: 18 Nov 19 | Expires: 18 Nov 24.
  24. PPL number: | Granted: 31 Jan 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/enteroendocrine_signalling_in_health_and_disease_nts_expires2024_redacted.pdf
    13 Sep 2021: PPL number: | Granted: 31 Jan 19 | Amended: 16 Jul 21 | Expires: 30 Jan 24. ... Contains severe proceduresRequired at inspector’s discretion. PPL number: | Granted: 31 Jan 19 | Amended: 16 Jul 21 | Expires: 30 Jan 24.
  25. Generation and screening of companion animal therapeutics.…

    https://www.ubs.admin.cam.ac.uk/system/files/public/generation_and_screening_of_companion_animal_therapeutics._non-technical_summary_redacted.pdf
    30 Apr 2024: Companion animal immunoglobulin. PPL number: | Granted: 10 Apr 24 | Expires: 10 Apr 29. ... Substances will be. PPL number: | Granted: 10 Apr 24 | Expires: 10 Apr 29.
  26. Understanding Infection Pathogenesis to Guide Therapies…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf
    30 Apr 2024: Mice that are immunised can show mild signs of discomfort that should last no more than 24 hours.
  27. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf
    30 Apr 2024: This allows unsuitable drugs to be. PPL number: | Granted: 24 Mar 22 | Expires: 24 Mar 27. ... Blood samples are usually small in volume and are. PPL number: | Granted: 24 Mar 22 | Expires: 24 Mar 27.
  28. The development of in vivo expressed biologics as a platform for…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 18 Apr 23 | Amended: 28 Mar 24 | Expires: 18 Apr 28. ... Reduction. PPL number: | Granted: 18 Apr 23 | Amended: 28 Mar 24 | Expires: 18 Apr 28.
  29. AWERB 3Rs Minutes 3rd January 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_030124_redacted.pdf
    30 Apr 2024: Subject AWERB 3Rs Committee Our Ref Doc.AWERB.3Rs.03.01.24. AWERB 3Rs Committee :. In attendance:. Minutes – Apologies:. 1. Minutes. The minutes of the meeting held on the 6th December
  30. The genetic and developmental basis of morphological and behavioural…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_genetic_and_developmental_basis_of_morphological_and_behavioural_variation_in_cichlid_fishes_no_redacted.pdf
    30 Apr 2024: Nonetheless, we will closely monitor the fish to detect any signs of suffering and stress during the procedure and in 24 hours following the procedure. ... This will require a maximum of 1800 animals. PPL number: | Granted: 29 Feb 24 | Expires: 28 Feb 29.
  31. The development of novel therapies (including cell and gene based…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 21 Mar 24 | Expires: 21 Mar 29. ... Over the period 24-96h, animals may show reduced appetite for food and water, which is expected to result in minor weight loss (less than 5-10% of their pre-operative
  32. Breeding and maintenance of rodents for drug discovery platform

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_and_maintenance_of_rodents_for_drug_discovery_platform_non-technical_summary_redacted.pdf
    29 Apr 2024: Haem A, Haem B, and Glanzmann mice sometimes have surface bleeds that can be treated, and these usually resolve over 24 hours. ... Sometimes Haem A mice can have bleeds from the ears that also can, in most cases, resolve within 24 hours.
  33. Mechanisms controlling cell division and cell identity during…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_controlling_cell_division_and_cell_identity_during_development_reprogramming_and_disease_redacted.pdf
    30 Apr 2024: These animals will be killed unless there are signs of recovery within 24 hours.
  34. PPL number: | Granted: 28 Oct 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_how_neutrophil_migration_behaviour_is_fine-tuned_during_inflammation_nts_redacted.pdf
    20 Aug 2021: PPL number: | Granted: 28 Oct 19 | Expires: 28 Oct 24.
  35. PPL number: | Granted: 29 Jan 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatment_strategies_for_myocardial_infarction_and_aortic_aneurysm_nts_expires2024_redacted.pdf
    13 Sep 2021: PPL number: | Granted: 29 Jan 19 | Amended: 03 Sep 21 | Expires: 28 Jan 24. ... Contains severe proceduresRequired at inspector’s discretion. PPL number: | Granted: 29 Jan 19 | Amended: 03 Sep 21 | Expires: 28 Jan 24.
  36. PPL number: | Granted: 01 Apr 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/evaluation_of_new_devices_to_be_used_in_human_surgery_nts_redacted.pdf
    20 Aug 2021: For laparoscopic procedures:. Potential adverse effects. PPL number: | Granted: 01 Apr 21 | Expires: 01 Apr 24. ... By combining as. PPL number: | Granted: 01 Apr 21 | Expires: 01 Apr 24.
  37. Neurobehavioural Mechanisms Underlying Mood, Anxiety and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_anxiety_and_stress-related_mental_health_disorders_non_redacted.pdf
    30 Apr 2024: We have published these findings in animal welfare journals. However, 24% of animals will need to experience more than three shocks, with the maximum number of footshocks that will be delivered ... Moderate: 76%. Severe: 24%. What will happen to animals
  38. Understanding the cell biology behind cardiovascular diseases…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf
    30 Apr 2024: subcutaneous 20ml/kg 2 24. Exceptions to this would be thioglycollate IP, which needs to be given in 1ml (standard practice), and the HDTV injection.
  39. PPL number: | Granted: 20 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/neural_basis_of_spatial_cognition_and_memory_in_the_hippocampus_nts_redacted.pdf
    20 Aug 2021: All surgical. PPL number: | Granted: 20 Nov 19 | Expires: 20 Nov 24. ... Reduction. PPL number: | Granted: 20 Nov 19 | Expires: 20 Nov 24.
  40. PPL number: | Granted: 10 Apr 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/genetic_and_developmental_basis_of_morphological_variation_in_cichlid_fish_nts_expires2024_redacted.pdf
    13 Sep 2021: PPL number: | Granted: 10 Apr 19 | Amended: 16 Jul 21 | Expires: 09 Apr 24.
  41. Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …

    https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 03 Jul 23 | Expires: 03 Jul 28. Downloaded: 9:27pm, 25 Apr 2024 Page 2 of 11. Objectives and benefitsDescription of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing.
  42. Metabolic basis of microglia function in development (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf
    30 Apr 2024: Similarly, researchers found that there was a 24% increased risk of depression, which increased the number of depressed individuals from an average of 10/1,000 to 14/1,000 in ... Since this is an experimental modelling of a viral infection, the female
  43. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 03 Feb 22 | Amended: 14 Mar 24 | Expires: 03 Feb 27. ... Ascites may occur. PPL number: | Granted: 03 Feb 22 | Amended: 14 Mar 24 | Expires: 03 Feb 27.
  44. PPL number: | Granted: 24 Sep 20 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_role_of_physical_cues_in_nervous_system_function_in_wild_type_and_transgenic_anima_redacted.pdf
    19 Aug 2021: PPL number: | Granted: 24 Sep 20 | Amended: 05 Feb 21 | Expires: 24 Sep 25. ... Objectives and benefits. PPL number: | Granted: 24 Sep 20 | Amended: 05 Feb 21 | Expires: 24 Sep 25.
  45. New treatments for renal and liver disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: Even with timely dialysis, the death rates in patients with kidney failure vary from 20% to 50% over 24 months.
  46. Development of humanised mouse models for study of cancer…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_humanised_mouse_models_for_study_of_cancer_immunotherapy_non-technical_summary_redacted.pdf
    29 Apr 2024: In such cases, the animals will be culled if these clinical signs do not respond to treatment (such as high energy and easily digestible diet) and persist for up to 24
  47. PPL number: | Granted: 16 Apr 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_of_mental_health_nts_expires2023_redacted.pdf
    13 Sep 2021: If no improvement was shown within 24 hours, then the animal would be humanely killed.
  48. PPL number: | Granted: 19 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_of_transgenic_rodents_for_supply_of_tissues_to_the_client_nts_redacted.pdf
    20 Aug 2021: Theories and ideas can. PPL number: | Granted: 19 Nov 19 | Expires: 19 Nov 24. ... Page 8 of 11. PPL number: | Granted: 19 Nov 19 | Expires: 19 Nov 24.
  49. PPL number: | Granted: 21 Jan 20 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_long-term_effects_of_developmental_hypoxia_on_cardiac_function_nts_redacted.pdf
    19 Aug 2021: 4. For moderate levels of prenatal hypoxia (below 13% oxygen), rats will first be put into the chamber at normal oxygen levels (21%) for 24 hours, and then oxygen will be ... reduced slowly (over another 24-hour period) to avoid shock.
  50. Determining mechanisms of tumour development and relapse following…

    https://www.ubs.admin.cam.ac.uk/system/files/public/determining_mechanisms_of_tumour_development_and_relapse_following_treatment_non-technical_summary_redacted.pdf
    29 Apr 2024: As the mice are checked daily, at most, a mouse would experience paralysis for no more than 24 hours.
  51. University of Cambridge AWERB Handbook Version 6.6 2nd March ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/02.03.2021_awerb_handbook_6.6_external.pdf
    3 Mar 2021: University of Cambridge AWERB Handbook Version 6.6 2nd March 2021. 0. Advice based on Animals (Scientific Procedures) Act 1986. As reviewed and transposed 1 January 2012 and Amended 1 January 2013. University Biomedical Services. Table of Contents.

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