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AWERB Sub-Standing Committee Meeting Minutes - 5th March 2021
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_050321_redacted.pdf7 Dec 2022: Minutes of AWERB Standing Committee meeting 24/02/21 The minutes were not available 4. -
AWERB Sub-Standing Committee Meeting Minutes - 10th January 2020
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_100120_redacted_0.pdf7 Dec 2022: Further information added in regards to weight loss persisting for 24 hours in Protocol 16. • -
Multi-tissue mechanics in the development and engineering of the…
https://www.ubs.admin.cam.ac.uk/system/files/public/multi-tissue_mechanics_in_the_development_and_engineering_of_the_posterior_body_axis_non-technical_redacted.pdf30 Apr 2024: Note that in this. PPL number: | Granted: 24 Oct 23 | Expires: 24 Oct 28. ... The number of. PPL number: | Granted: 24 Oct 23 | Expires: 24 Oct 28. -
PPL number: | Granted: 30 Jul 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/neural_regulation_of_fertility_nts_expires2024_redacted.pdf13 Sep 2021: PPL number: | Granted: 30 Jul 19 | Amended: 17 Aug 21 | Expires: 29 Jul 24. -
Nutrient sensing in the brain
https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf30 Apr 2024: PPL number: | Granted: 12 Jan 22 | Amended: 03 Feb 24 | Expires: 12 Jan 27. ... The PPL holder will be required to disclose:. PPL number: | Granted: 12 Jan 22 | Amended: 03 Feb 24 | Expires: 12 Jan 27. -
Cartilage repair and replacement
https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf29 Apr 2024: Animals will also be individually housed (but within close proximity and line of sight to the rest of the 'flock') in the 24-48 hours prior to surgery. ... 4 or less). Followed by longer (e.g. 3, 6, 12 or 24 months), larger studies (less than 10 animals -
PPL number: | Granted: 06 Aug 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/mice_with_transgenic_immunoglobulin_loci_nts_redacted.pdf20 Aug 2021: PPL number: | Granted: 06 Aug 19 | Amended: 20 Nov 20 | Expires: 05 Aug 24. ... this mice will be anaesthetised during dosing and will be given suitable pain relief until they return to normal roughly 24-48 hours later. -
Mechanisms of organ development and disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_of_organ_development_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: PPL number: | Granted: 25 Oct 23 | Amended: 29 Feb 24 | Expires: 25 Oct 28. ... Refinement. PPL number: | Granted: 25 Oct 23 | Amended: 29 Feb 24 | Expires: 25 Oct 28. -
AWERB 3Rs Minutes 5th July 2023 Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_050723_redacted.pdf14 May 2024: Highlights of AWERB Standing meeting 24/05/23 None. 10. Highlights of January AOC meeting 19/05/23 None. -
In vivo compressive forces (non-technical summary)_Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf30 Apr 2024: The neural crest cells are formed over approximately 24 hours. This means that we can put the intact embryo under a specialised microscope and can easily image the whole process of -
Molecular mechanisms of tolerance and immunosuppression…
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_tolerance_and_immunosuppression_non-technical_summary_redacted.pdf30 Apr 2024: PPL number: | Granted: 20 Apr 23 | Amended: 24 Aug 23 | Expires: 20 Apr 28. ... be. PPL number: | Granted: 20 Apr 23 | Amended: 24 Aug 23 | Expires: 20 Apr 28. -
PPL number: | Granted: 07 Aug 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/microglial_targets_in_brain_pathology_and_ageing_nts_redacted.pdf20 Aug 2021: PPL number: | Granted: 07 Aug 19 | Expires: 06 Aug 24. -
PPL number: | Granted: 03 Jul 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/regeneration_in_the_nervous_system_nts_expires2024_redacted.pdf13 Sep 2021: PPL number: | Granted: 03 Jul 19 | Amended: 09 Sep 21 | Expires: 14 Jan 24. ... Contains severe procedures. Objectives and benefits. PPL number: | Granted: 03 Jul 19 | Amended: 09 Sep 21 | Expires: 14 Jan 24. -
Interaction between the immune system and tumours (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf30 Apr 2024: Tumour organoids do have more of. PPL number: | Granted: 03 Jan 24 | Expires: 03 Jan 29. ... Animals that enter experimental. PPL number: | Granted: 03 Jan 24 | Expires: 03 Jan 29. -
Proteotoxicity in development and ageing (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/proteotoxicity_in_development_and_ageing_non-technical_summary_redacted.pdf30 Apr 2024: In summary, mice will be aged up to the age of 24 months. ... Some genetically altered mice will be maintained for ageing until they reach a maximum of 24 months of age. -
Potent monoclonal antibodies for biologics discovery (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/potent_monoclonal_antibodies_for_biologics_discovery_non-technical_summary_redacted.pdf30 Apr 2024: This can benefit a wider scientific community. PPL number: | Granted: 08 Mar 24 | Expires: 08 Mar 29. ... Mice. Mild Severity - 100%. Moderate severity - 0%. Rats. PPL number: | Granted: 08 Mar 24 | Expires: 08 Mar 29. -
Code of Practice for the Housing and Care of ...
https://www.ubs.admin.cam.ac.uk/files/cop_housing_care_for_sci_purp.pdf18 Sep 2015: 5.1 Accommodation specifications 22. Section 1, Chapter 3: Rabbits 24 – 261 Accommodation specifications 24. ... 1.1 Doe plus litter 241.2 Breeding animals and post-weaned stock 241.3 Rabbits being used in procedures 24. -
AWERB 3Rs Minutes 1st March 2023 Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_010323_redacted.pdf14 May 2024: If an animal does not improve within. 72 hours then they may not be euthanised for a further 24 hours. -
Cancer and its microenvironment! From mechanisms to translation…
https://www.ubs.admin.cam.ac.uk/system/files/public/cancer_and_its_microenvironment_from_mechanisms_to_translation_non-technical_summary_redacted.pdf30 Apr 2024: PPL number: | Granted: 25 Jan 23 | Amended: 24 Jan 24 | Expires: 25 Jan 28. ... lung. PPL number: | Granted: 25 Jan 23 | Amended: 24 Jan 24 | Expires: 25 Jan 28. -
Biobehavioural basis of the individual vunerability to impulsive…
https://www.ubs.admin.cam.ac.uk/system/files/public/biobehavioural_basis_of_the_individual_vulnerability_to_impulsivecompulsive_spectrum_disorders_redacted.pdf29 Apr 2024: PPL number: | Granted: 14 Jan 22 | Amended: 24 Jan 22 | Expires: 14 Jan 27. ... with. PPL number: | Granted: 14 Jan 22 | Amended: 24 Jan 22 | Expires: 14 Jan 27. -
Pharmacological evaluation of imaging agents and development of…
https://www.ubs.admin.cam.ac.uk/system/files/public/pharmacological_evaluation_of_imaging_agents_and_development_of_imaging_applications_and_methods_no_redacted.pdf30 Apr 2024: Production of the candidate imaging agent. PPL number: | Granted: 16 Feb 24 | Expires: 16 Feb 29. ... Mice. Non-recovery: 64%. Mild: 36%. Moderate: 0%. Severe: 0%. Rats. PPL number: | Granted: 16 Feb 24 | Expires: 16 Feb 29. -
PPL number: | Granted: 18 Nov 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/generation_of_novel_antibodies_with_therapeutic_potential_nts_redacted.pdf20 Aug 2021: What's the aim of this project? PPL number: | Granted: 18 Nov 19 | Expires: 18 Nov 24. ... Refinement. PPL number: | Granted: 18 Nov 19 | Expires: 18 Nov 24. -
PPL number: | Granted: 31 Jan 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/enteroendocrine_signalling_in_health_and_disease_nts_expires2024_redacted.pdf13 Sep 2021: PPL number: | Granted: 31 Jan 19 | Amended: 16 Jul 21 | Expires: 30 Jan 24. ... Contains severe proceduresRequired at inspector’s discretion. PPL number: | Granted: 31 Jan 19 | Amended: 16 Jul 21 | Expires: 30 Jan 24. -
Generation and screening of companion animal therapeutics.…
https://www.ubs.admin.cam.ac.uk/system/files/public/generation_and_screening_of_companion_animal_therapeutics._non-technical_summary_redacted.pdf30 Apr 2024: Companion animal immunoglobulin. PPL number: | Granted: 10 Apr 24 | Expires: 10 Apr 29. ... Substances will be. PPL number: | Granted: 10 Apr 24 | Expires: 10 Apr 29. -
Understanding Infection Pathogenesis to Guide Therapies…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf30 Apr 2024: Mice that are immunised can show mild signs of discomfort that should last no more than 24 hours. -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf30 Apr 2024: This allows unsuitable drugs to be. PPL number: | Granted: 24 Mar 22 | Expires: 24 Mar 27. ... Blood samples are usually small in volume and are. PPL number: | Granted: 24 Mar 22 | Expires: 24 Mar 27. -
The development of in vivo expressed biologics as a platform for…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf30 Apr 2024: PPL number: | Granted: 18 Apr 23 | Amended: 28 Mar 24 | Expires: 18 Apr 28. ... Reduction. PPL number: | Granted: 18 Apr 23 | Amended: 28 Mar 24 | Expires: 18 Apr 28. -
AWERB 3Rs Minutes 3rd January 2024
https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_030124_redacted.pdf30 Apr 2024: Subject AWERB 3Rs Committee Our Ref Doc.AWERB.3Rs.03.01.24. AWERB 3Rs Committee :. In attendance:. Minutes – Apologies:. 1. Minutes. The minutes of the meeting held on the 6th December -
The genetic and developmental basis of morphological and behavioural…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_genetic_and_developmental_basis_of_morphological_and_behavioural_variation_in_cichlid_fishes_no_redacted.pdf30 Apr 2024: Nonetheless, we will closely monitor the fish to detect any signs of suffering and stress during the procedure and in 24 hours following the procedure. ... This will require a maximum of 1800 animals. PPL number: | Granted: 29 Feb 24 | Expires: 28 Feb 29. -
The development of novel therapies (including cell and gene based…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf30 Apr 2024: PPL number: | Granted: 21 Mar 24 | Expires: 21 Mar 29. ... Over the period 24-96h, animals may show reduced appetite for food and water, which is expected to result in minor weight loss (less than 5-10% of their pre-operative -
Breeding and maintenance of rodents for drug discovery platform
https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_and_maintenance_of_rodents_for_drug_discovery_platform_non-technical_summary_redacted.pdf29 Apr 2024: Haem A, Haem B, and Glanzmann mice sometimes have surface bleeds that can be treated, and these usually resolve over 24 hours. ... Sometimes Haem A mice can have bleeds from the ears that also can, in most cases, resolve within 24 hours. -
Mechanisms controlling cell division and cell identity during…
https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_controlling_cell_division_and_cell_identity_during_development_reprogramming_and_disease_redacted.pdf30 Apr 2024: These animals will be killed unless there are signs of recovery within 24 hours. -
PPL number: | Granted: 28 Oct 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_how_neutrophil_migration_behaviour_is_fine-tuned_during_inflammation_nts_redacted.pdf20 Aug 2021: PPL number: | Granted: 28 Oct 19 | Expires: 28 Oct 24. -
PPL number: | Granted: 29 Jan 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatment_strategies_for_myocardial_infarction_and_aortic_aneurysm_nts_expires2024_redacted.pdf13 Sep 2021: PPL number: | Granted: 29 Jan 19 | Amended: 03 Sep 21 | Expires: 28 Jan 24. ... Contains severe proceduresRequired at inspector’s discretion. PPL number: | Granted: 29 Jan 19 | Amended: 03 Sep 21 | Expires: 28 Jan 24. -
PPL number: | Granted: 01 Apr 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/evaluation_of_new_devices_to_be_used_in_human_surgery_nts_redacted.pdf20 Aug 2021: For laparoscopic procedures:. Potential adverse effects. PPL number: | Granted: 01 Apr 21 | Expires: 01 Apr 24. ... By combining as. PPL number: | Granted: 01 Apr 21 | Expires: 01 Apr 24. -
Neurobehavioural Mechanisms Underlying Mood, Anxiety and…
https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_anxiety_and_stress-related_mental_health_disorders_non_redacted.pdf30 Apr 2024: We have published these findings in animal welfare journals. However, 24% of animals will need to experience more than three shocks, with the maximum number of footshocks that will be delivered ... Moderate: 76%. Severe: 24%. What will happen to animals -
Understanding the cell biology behind cardiovascular diseases…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf30 Apr 2024: subcutaneous 20ml/kg 2 24. Exceptions to this would be thioglycollate IP, which needs to be given in 1ml (standard practice), and the HDTV injection. -
PPL number: | Granted: 20 Nov 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/neural_basis_of_spatial_cognition_and_memory_in_the_hippocampus_nts_redacted.pdf20 Aug 2021: All surgical. PPL number: | Granted: 20 Nov 19 | Expires: 20 Nov 24. ... Reduction. PPL number: | Granted: 20 Nov 19 | Expires: 20 Nov 24. -
PPL number: | Granted: 10 Apr 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/genetic_and_developmental_basis_of_morphological_variation_in_cichlid_fish_nts_expires2024_redacted.pdf13 Sep 2021: PPL number: | Granted: 10 Apr 19 | Amended: 16 Jul 21 | Expires: 09 Apr 24. -
Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …
https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf30 Apr 2024: PPL number: | Granted: 03 Jul 23 | Expires: 03 Jul 28. Downloaded: 9:27pm, 25 Apr 2024 Page 2 of 11. Objectives and benefitsDescription of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing. -
Metabolic basis of microglia function in development (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf30 Apr 2024: Similarly, researchers found that there was a 24% increased risk of depression, which increased the number of depressed individuals from an average of 10/1,000 to 14/1,000 in ... Since this is an experimental modelling of a viral infection, the female -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf30 Apr 2024: PPL number: | Granted: 03 Feb 22 | Amended: 14 Mar 24 | Expires: 03 Feb 27. ... Ascites may occur. PPL number: | Granted: 03 Feb 22 | Amended: 14 Mar 24 | Expires: 03 Feb 27. -
PPL number: | Granted: 24 Sep 20 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_role_of_physical_cues_in_nervous_system_function_in_wild_type_and_transgenic_anima_redacted.pdf19 Aug 2021: PPL number: | Granted: 24 Sep 20 | Amended: 05 Feb 21 | Expires: 24 Sep 25. ... Objectives and benefits. PPL number: | Granted: 24 Sep 20 | Amended: 05 Feb 21 | Expires: 24 Sep 25. -
New treatments for renal and liver disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf30 Apr 2024: Even with timely dialysis, the death rates in patients with kidney failure vary from 20% to 50% over 24 months. -
Development of humanised mouse models for study of cancer…
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_humanised_mouse_models_for_study_of_cancer_immunotherapy_non-technical_summary_redacted.pdf29 Apr 2024: In such cases, the animals will be culled if these clinical signs do not respond to treatment (such as high energy and easily digestible diet) and persist for up to 24 -
PPL number: | Granted: 16 Apr 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_of_mental_health_nts_expires2023_redacted.pdf13 Sep 2021: If no improvement was shown within 24 hours, then the animal would be humanely killed. -
PPL number: | Granted: 19 Nov 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_of_transgenic_rodents_for_supply_of_tissues_to_the_client_nts_redacted.pdf20 Aug 2021: Theories and ideas can. PPL number: | Granted: 19 Nov 19 | Expires: 19 Nov 24. ... Page 8 of 11. PPL number: | Granted: 19 Nov 19 | Expires: 19 Nov 24. -
PPL number: | Granted: 21 Jan 20 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/the_long-term_effects_of_developmental_hypoxia_on_cardiac_function_nts_redacted.pdf19 Aug 2021: 4. For moderate levels of prenatal hypoxia (below 13% oxygen), rats will first be put into the chamber at normal oxygen levels (21%) for 24 hours, and then oxygen will be ... reduced slowly (over another 24-hour period) to avoid shock. -
Determining mechanisms of tumour development and relapse following…
https://www.ubs.admin.cam.ac.uk/system/files/public/determining_mechanisms_of_tumour_development_and_relapse_following_treatment_non-technical_summary_redacted.pdf29 Apr 2024: As the mice are checked daily, at most, a mouse would experience paralysis for no more than 24 hours. -
University of Cambridge AWERB Handbook Version 6.6 2nd March ...
https://www.ubs.admin.cam.ac.uk/system/files/public/02.03.2021_awerb_handbook_6.6_external.pdf3 Mar 2021: University of Cambridge AWERB Handbook Version 6.6 2nd March 2021. 0. Advice based on Animals (Scientific Procedures) Act 1986. As reviewed and transposed 1 January 2012 and Amended 1 January 2013. University Biomedical Services. Table of Contents.
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