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Structure of a cholinergic cell membraneNigel Unwina,1 Edited by ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnasS22.pdf4 Nov 2022: The broken yellow lines identify the well-documented ribbon of δ subunit-linked receptor dimers(14, 15, 18, 24), one of which is labeled in each leaflet to indicate the subunit ... Biophys. J. 92, 3960–3967 (2007). 24. H. W. Chang, E. Bock, Molecular -
Proteins required for processing the end of mRNAs identified - MRC…
https://www2.mrc-lmb.cam.ac.uk/proteins-required-for-processing-the-end-of-mrnas-identified/17 May 2022: Lori Passmore’s group in the LMB’s Structural Studies Division has shown that Mpe1 in yeast and RBBP6 in humans are critical for activating CPF and CPSF respectively, protein complexes vital to cleavage process of mRNA. -
Mammalian clock gene Cryptochrome 1 is crucial to suprachiasmatic…
https://www2.mrc-lmb.cam.ac.uk/mammalian-clock-gene-cryptochrome-1-is-crucial-to-suprachiasmatic-nucleus-timekeeping/31 Aug 2022: These organotypic slices are ideal to investigate circadian rhythms as, when cultured ex vivo, they maintain a robust circadian rhythm over a roughly 24-hour period and in effect serve as -
Structural study reveals a novel activation mechanism for the fungal…
https://www2.mrc-lmb.cam.ac.uk/structural-study-reveals-a-novel-activation-mechanism-for-the-fungal-gpcr-ste2/16 Mar 2022: Chris Tate’s group, in the LMB’s Structural Studies Division, have used cryo-EM analysis to show that Ste2, a fungal Class D GPCR, has a fundamentally distinct activation mechanism in comparison to other types of GPCRs. -
Cryo-EM structures reveal molecular basis of human telomerase…
https://www2.mrc-lmb.cam.ac.uk/cryo-em-structures-reveal-molecular-basis-of-human-telomerase-recruitment/25 Feb 2022: Kelly Nguyen’s group in the LMB’s Structural Studies Division has determined the molecular basis of how the TPP1 and POT1 components of shelterin recruit human telomerase to telomeres and regulate the enzyme’s activity during genomic -
The age-old problem of telomere maintenance - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/the-age-old-problem-of-telomere-maintenance/24 Nov 2022: Published on. 24 November, 2022. Kelly Nguyen, a Group Leader in the LMB’s Structural Studies Division, was awarded the 2022 Eppendorf Award for Young European Investigators earlier this year. -
Venki Ramakrishnan appointed to the Order of Merit - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/venki-ramakrishnan-appointed-to-the-order-of-merit/14 Nov 2022: Appointments to the Order are in the Sovereign’s personal gift. The Order is restricted to 24 members. -
New method to discover protease and other hydrolase substrates in…
https://www2.mrc-lmb.cam.ac.uk/new-method-to-discover-protease-and-other-hydrolase-substrates-in-live-mammalian-cells/17 Feb 2022: Using genetic code expansion techniques, Jason Chin’s group in the LMB’s PNAC Division have designed a new mechanism-based, light-activated technique to trap and identify new protease and other hydrolase substrates. -
Paul Sigler (1934 - 2000) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/paul-sigler-1934-2000/2 Nov 2022: Nature, 403, 848 (2000) by Brian Matthews. Cell, 101, 23-24 (2000) by Max Perutz. -
Cryptochrome proteins are integral to maintain time within the…
https://www2.mrc-lmb.cam.ac.uk/cryptochrome-proteins-are-integral-to-maintain-time-within-the-brains-master-clock/20 Jan 2022: Using synthetic biological techniques, Michael Hastings’ group have collaborated with Jason Chin to gain novel insights into the molecular and cellular processes which govern the suprachiasmatic nucleus, and identified a key regulatory role of
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