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BBC News 24 : Hopes over 'ending' common cold - MRC…
https://www2.mrc-lmb.cam.ac.uk/bbc-news-24-hopes-over-ending-common-cold/2 Nov 2010: Search this website. BBC News 24 : Hopes over ‘ending’ common cold. ... BBC News 24 : Hopes over ‘ending’ common cold. Published on. -
LMB continues pioneering work started in CPE - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/lmb-continues-pioneering-work-started-in-cpe/24 Sep 2010: Published on. 24 September, 2010. A pioneering MRC research unit in Cambridge focused on the structure, stability and activity of proteins and the engineering of antibodies is closing after 20 years -
Michael Hastings elected Fellow of the Royal Society - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/michael-hastings-elected-fellow-of-the-royal-society/21 May 2010: The Hastings group are now investigating how the body clock genes are able to assemble a 24 hour time-keeper and how the different timers together co-ordinate our highly complex -
Body clock drugs could ease psychiatric disorders and jet lag - MRC…
https://www2.mrc-lmb.cam.ac.uk/body-clock-drugs-could-ease-psychiatric-disorders-and-jet-lag-2/26 Aug 2010: Each ‘tick’ as represented by the rise and fall of a wave over a 24-hour period. ... Any change in casein kinase 1 activity, faster or slower, would adjust the ‘ticking’ from 24 hours to some other time period. -
Body clock drugs could ease psychiatric disorders and jet lag - MRC…
https://www2.mrc-lmb.cam.ac.uk/body-clock-drugs-could-ease-psychiatric-disorders-and-jet-lag/24 Aug 2010: 24 August, 2010. “Researchers have successfully used a drug to reset and restart the natural 24 hour body clock of mice in the lab. ... team of scientists from Pfizer led by Dr Travis Wager, and is published August 24 in PNAS.”Primary Sidebar. -
Body clock pills 'could cure jet lag and manic depression' -…
https://www2.mrc-lmb.cam.ac.uk/body-clock-pills-could-cure-jet-lag-and-manic-depression/24 Aug 2010: 24 August, 2010. “A team of British and American scientists have found a drug which can slow down, kick start and reset the body clocks of mice. -
Venki Ramakrishnan elected Honorary Fellow of the Academy of Medical…
https://www2.mrc-lmb.cam.ac.uk/venki-ramakrishnan-elected-honorary-fellow-of-the-academy-of-medical-sciences/5 Jul 2010: Venki will be presented with his Honorary Fellowship at the Academy’s Annual Meeting on 24 November 2011 in London. -
A Large Particle Associated with the Perimeter of the ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/jcb82.pdf5 Jul 2010: Best preserved porecomplexes show evidence of 16- and 24-fold harmonics inaddition to the basic eightfold harmonic (Fig. ... J. CellBiol. 52:338-354. 24. Paine, P. L. , L, C. Moore, and S. -
Many bacterial plasmids are maintained at low copy number ...
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nrmicro2425.pdf14 Sep 2010: This relationship was confirmed by the crystal structure of ParM, which revealed a fold and domain arrangement very similar to that of globular actin (G-actin)24 (FIG. ... 24) 166.2 (REF. 89). Kinetic parameters. Critical concentration (ATP) 2.3 μM18 -
Bacterial actin MreB assembles in complex with cell shape protein RodZ
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/embo2010RodZMreB.pdf17 Feb 2010: The crystals were cryoprotected with mother liquorcontaining 24.8% PEG400 and flash frozen in liquid nitrogen. ... The plate was incubated at 301Cand imaged after 24 h. DrodZ complementation assays and microscopy. -
www.landesbioscience.com Autophagy 805 Autophagy 6:6, 805-807; August …
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20574157.pdf2 Aug 2010: Submitted: 05/24/10. Revised: 06/03/10. Accepted: 06/03/10. Previously published online: www.landesbioscience.com/journals/autophagy/article/12577Correspondence to: Roger L. -
Features critical for membrane binding revealed by DivIVA crystal…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/emboj201099a.pdf20 May 2010: 21.7) 24.1 (ano. 14.1) 3.8 4.3 (ano. 2.5) 2.8. Phasing Se SAD Ta SAD MR I SAD MRNumber of sites 6 5 8Mean FOM -
Crystal Structures of Bacillus subtilis Lon Protease
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/londumanjmb2010.pdf20 Jul 2010: electron microscopy data show that negativelystained images of E. coli Lon particles appearhexameric,24 although surprisingly, electron cryo-microscopy images of S. -
DOI: 10.1126/science.1184429 , 1638 (2010); 327Science et al.Simon…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20339072.pdf2 Aug 2010: 9, 1142 (2007).23. C. Liang et al., Nat. Cell Biol. 10, 776 (2008).24. ... 1), factorially manipulatedpredator access and soil fertility, and monitoredplant biomass and populations of the potentherbivore Aphis nerii (Aphididae, Hemiptera), aspecialist on -
Dynamin architecture—from monomer to polymer
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/dynaminreviewCOSBILow2010.pdf21 Oct 2010: J Mol Med 2010, 88:339-350. 24. Ramachandran R, Schmid SL: Real-time detection reveals thateffectors couple dynamin’s GTP-dependent conformationalchanges to the membrane. -
Coot: Model-building tools for Molecular Graphics
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/coot-nottingham-jan-2010.pdf7 Jan 2010: Slide 19. Slide 20. Slide 21. Slide 22. Slide 23. Slide 24. -
201010176 1..6
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/PNAS-2010-Aylett-TubZ.pdf21 Oct 2010: Edited by Stephen C. Harrison, Harvard Medical School, Boston, MA, and approved September 24, 2010 (received for review July 13, 2010). -
JFCregg_OGS_finaledit
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/Cregg_thesis.pdf14 Dec 2010: Egg-laying. 17. Neurophysiology in C. elegans. 24. Electrophysiology. 25. vi. Calcium Imaging. ... receptors. The worms will eventually (in 12 – 24 hrs) adapt to high levels of. -
Doc2b Is a High-Affinity Ca2+ Sensor forSpontaneous Neurotransmitter…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/GroffenScience2010.pdf30 Apr 2010: S1) (24). Doc2b/ mice did not expressthe remaining exons and lacked Doc2b immuno-reactivity. ... Neurosci. 24, 1226 (2004).16. A. Maximov, O. H. Shin, X. Liu, T. -
A positively charged channel within the Smc1/Smc3 hinge required for…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/embosmcjingekurze2010.pdf1 Dec 2010: Smc1DDSmc3AAA. Smc1Smc3AAA. Kd = 22 nM Kd = 29 nM Kd = 24 nM. ... The Kd for Smc1DD and Smc3AAA hingedomain association is 29 nM (middle panel) and 24 nM for Smc1 wild-type and Smc3AAA (right panel). -
Roles of Amphipathic Helices and the Bin/Amphiphysin/Rvs(BAR) Domain…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Jao_JBC2010.pdf4 Oct 2010: Distances 20Å were investigated using four-pulse DEER (24–27), whereasshorter distances were investigated using continuous wave EPR(28, 29) (see “Experimental Procedures”).The DEER measurements are illustrated with the example ... Mutant -
Modeling membrane shaping by proteins: Focus on EHD2 and N-BAR domains
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/KozlovEHDs.pdf7 Apr 2010: 18–20]), the BAR domain con-taining proteins [14,21–24], EHD2 [25], the complexes of clathrinwith adaptor and accessory proteins (see for reviews e.g. -
bst641-09a
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/19614567.pdf2 Aug 2010: In contrast with the class IA enzymes, the single class IBisotype, p110γ , associates with p101 [23] or the closely relatedp84–p87 regulatory subunits [24,25]; neither subunit has arecognizable domain organization ... The p84–p110γ heterodimer is -
©20 10 N atur e A mer ica, Inc. ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20081827.pdf2 Aug 2010: Impaired PI(3)K signaling results in severe defects of innate and adaptive immune responses, suggesting that targeting of this isoform would be a beneficial therapeutic strategy20,24. ... Biochem. Soc. Trans. 35, 245–249 (2007). 24. Ameriks, M.K. & -
The Acetyltransferase Activity of the Bacterial Toxin YopJ ofYersinia …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Mittal_JBC2010.pdf4 Oct 2010: The Acetyltransferase Activity of the Bacterial Toxin YopJ ofYersinia Is Activated by Eukaryotic Host Cell InositolHexakisphosphateSReceived for publication, March 24, 2010, and in revised form, April 23, 2010 Published, JBC Papers ... They are also the -
Quality and quantity control at the endoplasmic reticulum
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/65_Hegde_RS_COCB_2010.pdf7 Jun 2010: EMBO J 2005,24:149-159. 55. Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY:Hrd1p/Der3p is a membrane-anchored ubiquitin ligaserequired for ER-associated degradation. ... EMBO J 2005, 24:3917-3926. 57. Isaacson MK, Ploegh HL: Ubiquitination, -
Chapter 20 In Vitro Dissection of Protein Translocationinto the ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/62_Sharma_AS_MMB_2010.pdf30 Apr 2010: Chapter 20. In Vitro Dissection of Protein Translocationinto the Mammalian Endoplasmic Reticulum. Ajay Sharma, Malaiyalam Mariappan, Suhila Appathurai,and Ramanujan S. Hegde. Abstract. In eukaryotic cells, roughly one-fourth of all mRNAs code for -
Protein-driven membrane stresses in fusion and fission
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Kozlov%20Trends%20Biochem%20Sci%202010.pdf20 Nov 2010: Frequent observations of a complex network ofconnected tubules with an extensive surface area implythat considerable EHD2-driven fusion occurs betweentubulated liposomes [24]. ... 2009) The BAR domain superfamily: membrane-molding macromolecules. Cell 137 -
A ribosome-associating factor chaperones tail-anchored membrane…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/66_Mariappan_M_Nature_2010.pdf1 Aug 2010: Mol. Cell. Biol. 25, 10329–10337 (2005). 24. Halic, M. et al.
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