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doi:10.1016/j.str.2008.04.004
www-jackson.ch.cam.ac.uk/publications/2008/2008_Structure_Jackson_commentary.pdf1 Aug 2008: 2008). Biol. Cell, in press. Pub-lished online January 24, 2008. 10.1042/BC20070149. -
Exploring knotting mechanisms in protein foldingAnna L. Mallam,…
www-jackson.ch.cam.ac.uk/publications/2008/2008_PNAS_YibK_mutants.pdf8 Dec 2008: J Mol Biol346:1409 –1421. 24. Tanford C (1968) Protein denaturation. Part A. ... Theoretical models for the mechanismof denaturation. Adv Protein Chem 24:1–95. 26. -
doi:10.1016/j.jmb.2007.06.065
www-jackson.ch.cam.ac.uk/publications/2007/2007_J_mol_biol_Hsp90_inhibition.pdf8 Feb 2008: with a Kd of 29(3) nM, following incubationfor 24 h (Figure 2(d)). ... Kd (nM)4 h. Kd (nM)8 h. Kd (nM)24 h. kon(μM1 s1) koff. -
doi:10.1016/j.bpc.2007.03.011
www-jackson.ch.cam.ac.uk/publications/2007/2007_biophys_chem_UBQ.pdf8 Feb 2008: caused by aggregation of the native state, WT⁎ at 2 μM, pH 7.4and 37 C was equilibrated for 24 h in 300 g/L glucose. ... Side-. chain transfer is not, however, sufficient to overcome theunfavourable transfer of the backbone, as observed with -
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www-jackson.ch.cam.ac.uk/publications/2007/2007_JACS_spin_relaxation.pdf11 Feb 2008: W.; Fesinmeyer, R. M.; Andersen, N. H.Nature Struct. Biol. 2002, 9, 425-430.(24) Frisch, M. ... 2 ) 1.26 1020, HFC2 ) 6.24 1018, andXG,HFC) -4.26 1018. -
doi:10.1016/j.jmb.2008.02.013
www-jackson.ch.cam.ac.uk/publications/2008/2008_JMB_Hsp90_Hop.pdf4 Jun 2008: 5b), confirming that Cyp40 insolution exists in this state23,24, suggesting that theobserved structure of the tetragonal crystal form islikely to be a crystallographic artifact. ... Structure, 9, 431–438. 24. Ward, B. K., Allan, R. K., Mok, D., Temple, -
doi:10.1016/j.jmb.2007.04.059
www-jackson.ch.cam.ac.uk/publications/2007/2007_J_mol_biol_Hsp90+co.pdf8 Feb 2008: Structuresfor the isolated, individual domains have beenreported either for human or yeast Hsp90, the ERhomologue Grp94 or the Escherichia coli homologue,HtpG.18–24 In addition, a number of structures oflarger ... Trends Biochem. Sci. 24, 136–141. 4. -
Evidence of an Intermediate and Parallel Pathways in ProteinUnfolding …
www-jackson.ch.cam.ac.uk/publications/2008/2008_JACS_SM_GFP.pdf1 Aug 2008: AM. CHEM. SOC. 2008, 130, 7898–7907. identified as a continuum-of-substates,19 expansion or collapseof the unfolded state,18,23,24 or just assigned to changes in thedye’s ... Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 11539–11543. (24) Hoffmann, A.; -
doi:10.1016/j.str.2006.11.007
www-jackson.ch.cam.ac.uk/publications/2007/2007_structure_YibK.pdf8 Feb 2008: Sextuple 2.6 ( 0.4) 3 102 2.0 ( 0.6) 3 103 0.24 0.07 0.33 0.03 0.6 0.1 1.5 0.3. -
The extremely slow-exchanging core andacid-denatured state of green…
www-jackson.ch.cam.ac.uk/publications/2008/2008_HFSP_J_GFP.pdf19 Dec 2008: Neuberger, A (ed.), pp 23–24,Methuen, London. Mayo, SL, and Baldwin, RL (1993). -
doi:10.1016/j.jmb.2007.04.039
www-jackson.ch.cam.ac.uk/publications/2007/2007_J_mol_biol_GFP_unfolding.pdf8 Feb 2008: 19–24 as well as on cooperatively unfoldingregions of proteins.11,14 Although H/D exchangeresults have been reported for GFP, the conditionsused did not allow a quantitative analysis of theresults ... Thesymbols are the same as for (a) except the first -
doi:10.1016/j.jmb.2006.11.014
www-jackson.ch.cam.ac.uk/publications/2007/2007_J_mol_biol_YbeA+YibK.pdf8 Feb 2008: topology that led to the hypothesisthat topology, not sequence, is the major contribut-ing factor in how a protein folds.23,24 If proteinfolding rates and mechanisms are determinedlargely by the
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